MAGNETIC MICROPARTICLE SEPARATION DEVICE AND MICROFLUIDIC SYSTEM INCLUDING THE SAME
First Claim
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1. A device for separating a magnetic microparticle from a fluid sample containing the magnetic microparticle, comprising:
- a chamber to receive a buffer solution;
a channel including an inlet to receive the fluid sample and the magnetic microparticle, an outlet to discharge the fluid sample, a flow passage formed between the inlet and the outlet, and a connecting portion which is formed in a portion of the flow passage and fluid communicates with the chamber; and
a magnetic body disposed in a location where the distance between the magnetic body and the chamber is a smaller than the distance between the magnetic body and the channel,wherein the magnetic microparticle moves from the channel to the chamber through the connecting portion.
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Abstract
Provided are a magnetic microparticle separation device for separating and purifying target biomolecules and a microfluidic system using the device. The device includes a magnetic microparticle, a chamber to receive a buffer, a channel including an inlet, outlet and a connecting portion which is connected to and fluid communicates with the chamber, wherein a fluid sample containing the target biomolecules and magnetic microparticle flows through the channel and the magnetic microparticle which captures the target biomolecules are separated from the fluid sample.
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Citations
25 Claims
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1. A device for separating a magnetic microparticle from a fluid sample containing the magnetic microparticle, comprising:
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a chamber to receive a buffer solution; a channel including an inlet to receive the fluid sample and the magnetic microparticle, an outlet to discharge the fluid sample, a flow passage formed between the inlet and the outlet, and a connecting portion which is formed in a portion of the flow passage and fluid communicates with the chamber; and a magnetic body disposed in a location where the distance between the magnetic body and the chamber is a smaller than the distance between the magnetic body and the channel, wherein the magnetic microparticle moves from the channel to the chamber through the connecting portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A device for separating a magnetic microparticle from a fluid sample containing the magnetic microparticle, comprising:
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a chamber including a first inlet to receive a buffer solution, a first outlet to discharge the buffer solution, and a first flow passage formed between the first inlet and the first outlet; a channel including a second inlet to receive the fluid sample and the magnetic microparticle, a second outlet to discharge the fluid sample, a second flow passage formed between the second inlet and the second outlet, and a connecting portion which is formed in a portion of the second flow passage and flow communicates with the chamber; and a magnetic body disposed in a location where the distance between the magnetic body and the chamber is a smaller than the distance between the magnetic body and the channel, wherein magnetic microparticle moves from the channel to the chamber through the connecting portion. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16)
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17. A microfluidic system for separating a target biomolecule from a fluid sample which contains the target biomolecule using magnetic microparticles, the microfluidic system comprising at least one magnetic microparticle separation unit to separate the magnetic microparticles from the fluid sample,
wherein the magnetic microparticle separation unit comprises: -
a chamber to receive a buffer solution; a channel including an inlet to receive the fluid sample and the magnetic microparticle, an outlet to discharge the fluid sample, a flow passage formed between the inlet and the outlet, and a connecting portion which is formed in a portion of the flow passage and fluid communicates with the chamber; and a magnetic body disposed in a location where the distance between the magnetic body and the chamber is a smaller than the distance between the magnetic body and the channel, wherein the magnetic microparticle moves from the channel to the chamber through the connecting portion and is collected in the chamber. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25)
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Specification