Thermochromic compositions for skin applicaion

• US 20080026015A1
• Filed: 07/27/2006
• Published: 01/31/2008
• Est. Priority Date: 07/27/2006
• Status: Abandoned Application

• Current Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Original Assignee: Kimberly-Clark Worldwide Incorporated (Kimberly-Clark Corporation)
• Inventors: Schorr, Phillip, Brown, Tameka S., Oslund, Susan G., Linton, Lisa A., MacDonald, John Gavin, Arehart, Kelly D.
• Application Number:
  US11/494,252
• Publication Number:
  US 20080026015A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2800/412 Microsized, i.e. having sizes between 0.1 and 100 microns
• CPC Class Codes: A61K 2800/438 Thermochromatic; Photochromic; Phototropic
• CPC Class Codes: A61K 8/11 Encapsulated compositions
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61Q 17/005 Antimicrobial preparations

Abstract

Thermochromatic dyes may be added to compositions to be applied to skin in order to indicate where the composition is applied. After application to the skin the composition will turn from colored to colorless in a short period of time as its temperature rises in response to the curing reaction and to heat from the skin. The dyes are microencapsulated in order to avoid migration of the dye into the wound and to remain protected and functional. The dyes are selected such that they have a transition temperature between room temperature and that of the skin.

Claims

1. A composition for application to the skin comprising a thermochromic leuco dye.

4. The composition of claim 1 wherein said composition is a skin sealant comprising cyanoacrylate.

5. The composition of claim 1 that changes color in less than 4 minutes after application to skin.

6. The composition of claim 1 that changes color in less than 2 minutes after application to skin.

7. The composition of claim 1 that changes color in less than 1 minute after application to skin.

8. The composition of claim 1 further comprising a non-temperature sensitive dye.

9. The composition of claim 1 wherein said composition is a skin preparation comprising chlorhexidine gluconate.

10. The composition of claim 1 wherein said composition is a skin preparation comprising povidone-iodine.

2. The composition of claim 2 wherein said dye is microencapsulated.

3. The composition of claim 2 wherein said dye is present in an amount of between about 0.01 and 30 weight percent on a dry basis.

11. A temporary pattern composition comprising a temperature sensitive leuco dye that when applied to the skin is colorless but which becomes colored when the skin temperature is lower than normal.

12. The temporary pattern composition of claim 11 which becomes clear when the skin temperature rises to normal.

13. A method of indicating the surface coverage of a composition to be applied to the skin and of indicating that said composition has cured, comprising the steps of applying to an area of skin said composition having a first color and comprising a thermochromic leuco dye, and observing said color until said color changes to a second color, wherein the area of skin covered by said first color indicates the surface coverage and said second color indicates the composition has cured.

14. The method of claim 13 wherein said second color is clear.

15. The method of claim 13 wherein said composition further comprises a non-temperature sensitive dye.