Active agent-releasing dosage forms
First Claim
Patent Images
1. A pharmaceutical composition, comprising:
- a plurality of polymeric film layers heat sealed together as a multilayer structure; and
controlled amounts of active agent dissolved or dispersed in a liquid vehicle which have been ink-jetted on at least one of the plurality of polymeric film layers prior to being heat sealed together, wherein the active agent is within the multilayer structure.
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Abstract
The present invention provides pharmaceutical compositions. In one aspect, a pharmaceutical composition is provided having a plurality of polymeric film layers heat sealed together as a multilayer structure and having an active agent dispersed within the multilayer structure. The multilayer structure is configured to release the active agent upon administration to a subject, either in a controlled release or immediate release manner.
109 Citations
40 Claims
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1. A pharmaceutical composition, comprising:
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a plurality of polymeric film layers heat sealed together as a multilayer structure; and controlled amounts of active agent dissolved or dispersed in a liquid vehicle which have been ink-jetted on at least one of the plurality of polymeric film layers prior to being heat sealed together, wherein the active agent is within the multilayer structure. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of making a pharmaceutical composition, comprising:
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dispersing or dissolving an active agent in a liquid vehicle to form an ink-jettable composition; precisely ink-jetting the ink-jettable composition on at least one of a plurality of polymeric film layers; and heat sealing the plurality of polymeric film layers into a multilayer structure. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method of using a pharmaceutical composition, comprising administering to a subject a pharmaceutical composition including:
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a plurality of polymeric film layers heat sealed together as a multilayer structure; and controlled amounts of active agent dissolved or dispersed in a liquid vehicle which have been ink-jetted on at least one of the plurality of polymeric film layers prior to being heat sealed together, wherein the active agent is within the multilayer structure. - View Dependent Claims (31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A system for making a pharmaceutical composition, comprising:
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an ink-jetting means for digitally applying an active agent to only a portion of at least one of a plurality of polymeric film layers; and a heat sealing means for bonding the plurality of polymeric film layers into a multilayer structure such that the heat sealing occurs only where no active agent is present in the multilayer structure.
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Specification