Pharmaceutical compositions including nano-sized active agent
First Claim
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1. A particulate pharmaceutical composition, comprising:
- a water-soluble or partially water-soluble polymer matrix; and
a plurality of nano-sized particles of active agent which are sparingly water-soluble to water-insoluble dispersed in the water-soluble or partially water-soluble polymer matrix, wherein said particulate pharmaceutical composition is micronized, thereby forming individual micron-sized particles having a plurality of nano-sized particles present in the micron-sized particles.
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Abstract
The present invention is directed to a particulate pharmaceutical composition. The particulate pharmaceutical composition can comprise a water-soluble or partially water-soluble polymer matrix; and a plurality of nano-sized particles of active agent which are sparingly water-soluble to water-insoluble dispersed in the water-soluble or partially water-soluble polymer matrix. The particulate pharmaceutical composition can be micronized or in the form of a film that can be rolled up. If micronized, the individual micron-sized particles can have a plurality of nano-sized particles present in the micron-sized particles.
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Citations
35 Claims
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1. A particulate pharmaceutical composition, comprising:
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a water-soluble or partially water-soluble polymer matrix; and a plurality of nano-sized particles of active agent which are sparingly water-soluble to water-insoluble dispersed in the water-soluble or partially water-soluble polymer matrix, wherein said particulate pharmaceutical composition is micronized, thereby forming individual micron-sized particles having a plurality of nano-sized particles present in the micron-sized particles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 33, 34, 35)
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8. A rolled pharmaceutical composition, comprising:
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a water-soluble or partially water-soluble polymer matrix; and a plurality of nano-sized particles of active agent which are sparingly water-soluble to water-insoluble dispersed in the water-soluble or partially water-soluble polymer matrix, wherein said pharmaceutical composition in the form of a rolled up film. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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15. A method of making a pharmaceutical composition, comprising:
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a) dissolving a sparingly water-soluble to water-insoluble active agent in a solvent system comprising at least one organic solvent to form a dissolved active agent; b) applying the dissolved active agent to a water-soluble polymer matrix; c) at least partially dissolving the polymer matrix to form a paste containing the active agent and the polymer matrix; d) evaporating the organic solvent to form a nano-sized precipitate of the active agent, wherein the nano-sized precipitate is dispersed in the polymer matrix; and e) drying the polymer matrix containing the nano-sized precipitate. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32)
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Specification