Compositions and Methods for Treating Rotator Cuff Injuries

• US 20080027470A1
• Filed: 07/02/2007
• Published: 01/31/2008
• Est. Priority Date: 06/30/2006
• Status: Active Grant

• Current Assignee: Biomimetic Therapeutics LLC (Stryker Corporation)
• Original Assignee: Biomimetic Therapeutics LLC (Stryker Corporation)
• Inventors: Young, Conan, Hart, Charles, Lynch, Samuel, Nickols, Joshua
• Granted Patent: US 9,642,891 B2
• Time in Patent Office: Days
• US Class Current: 606/151
• CPC Class Codes: A61B 17/0401 Suture anchors, buttons or pledgets, i.e. means for attaching sutures to bone, cartilage or soft tissue; Instruments for applying or removing suture anchors A61B17/0642 takes precedence; fixation devices for tendons or ligaments A61F2/0811
• CPC Class Codes: A61B 2017/044 with a threaded shaft, e.g. screws
• CPC Class Codes: A61B 2017/0464 for soft tissue
• CPC Class Codes: A61F 2/0811 Fixation devices for tendons or ligaments
• CPC Class Codes: A61F 2002/0858 Fixation of tendon or ligament between anchor and bone, e.g. interference screws, wedges
• CPC Class Codes: A61F 2002/0876 Position of anchor in respect to the bone
• CPC Class Codes: A61K 38/1858 Platelet-derived growth factor [PDGF]
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 27/12 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/227 Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/54 Biologically active materials, e.g. therapeutic substances A61L27/227 takes precedence
• CPC Class Codes: A61P 21/00 Drugs for disorders of the muscular or neuromuscular system

Abstract

The present invention provides compositions and methods for attaching tendon to bone. The present invention provides compositions and methods for treating rotator cuff injuries. In one embodiment, a method for treating rotator cuff injuries comprises providing a composition comprising PDGF disposed in a biocompatible matrix and applying the composition to at least one site of tendon reattachment on the humeral head.

Claims

1. A method for attaching a tendon to a bone comprising:

providing a composition comprising a PDGF solution disposed in a biocompatible matrix; and

applying the composition to at least one site of tendon reattachment on the bone.

2. A method for treating rotator cuff tears comprising:

providing a composition comprising a PDGF solution disposed in a biocompatible matrix; and

applying the composition to at least one site of tendon reattachment on the humeral head.

3. The method of claim 2, wherein the at least one site of tendon attachment comprises a channel in cortical bone of the humeral head.

4. The method of claim 3, wherein the channel comprises a size and a shape that corresponds to a tendon attachment footprint.

5. The method of claim 2, further comprising disposing at least one bone anchor in the humeral head and coupling at least one detached tendon to the bone anchor.

6. The method of claim 5, wherein the at least one bone anchor comprises the PDGF solution disposed in the biocompatible matrix.

7. The method of claim 5, wherein the at least one tendon is coupled to the at least one bone anchor through at least one suture.

8. The method of claim 5, wherein disposing at least one bone anchor in the humeral head comprises drilling at least one hole in the humeral head.

9. The method of claim 2, further comprising molding the composition to contours of the tendon reattachment site.

10. The method of claim 2, wherein applying the composition comprises injecting the composition at the tendon reattachment site.

11. A method of treating a tendon comprising:

providing a composition comprising a PDGF solution disposed in a biocompatible matrix; and

applying the composition to a surface of at least one tendon.

12. The method of claim 11, wherein the at least one tendon has tearing, delamination, strain, or combinations thereof.

13. The method of claim 11, wherein the biocompatible matrix comprises a scaffolding material.

14. The method of claim 13, wherein the scaffolding material comprises β

-tricalcium phosphate.

15. The method of claim 13, wherein the scaffolding material comprises a collagen patch.

16. The method of claim 13, wherein the PDGF solution has a concentration of PDGF ranging from about 0.01 mg/ml to about 10 mg/ml.

17. The method of claim 13, wherein the PDGF solution has a concentration of PDGF ranging from about 0.1 mg/ml to about 0.3 mg/ml.

18. A method of strengthening the attachment of a tendon to bone comprising:

providing a composition comprising a PDGF solution disposed in a biocompatible matrix; and

applying the composition to a site of tendon attachment to bone.