Vagus Nerve Stimulation by Electrical Signals for Controlling Cerebellar Tremor
First Claim
1. A neurostimulator system for alleviating cerebellar tremor, comprising:
- a programmable electrical pulse generator; and
at least one electrode connected to the programmable electrical pulse generator; and
whereinthe programmable electrical pulse generator is programmed to generate electrical signals with the following parameters;
a signal frequency of 30 Hz or less, particularly 15 Hz or less,a current magnitude of not above 3 mA, in particular, not above 1 mA,a stimulation signal on-time to signal off-time ratio in the range of about 2;
1 to about 1;
2, and signal on-times and off-times in the range of about 10 seconds to about 5 minutes, anda pulse width within the range of 50 μ
s to 500 μ
s.
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Abstract
The present invention provides a neurostimulator system for alleviating cerebellar tremor, in particular, associated with multiple sclerosis, comprising a programmable electrical pulse generator; and at least one electrode connected with the programmable electrical pulse generator; and wherein the programmable electrical pulse generator is programmed to generate electrical signals with the following parameters: a current magnitude of not above 3 mA, in particular, not above 1 mA, a stimulation signal on-time to signal off-time ratio in the range of about 2:1 to about 1:2, and signal on-times and off-times in the range of about 10 seconds to about 5 minutes, a signal frequency below 30 Hz, and a pulse width within the interval of 50 μs to 500 μs. A method for manufacturing a neurostimulator system for alleviating cerebellar tremor associated with multiple sclerosis is also disclosed.
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Citations
23 Claims
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1. A neurostimulator system for alleviating cerebellar tremor, comprising:
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a programmable electrical pulse generator; and at least one electrode connected to the programmable electrical pulse generator; and
whereinthe programmable electrical pulse generator is programmed to generate electrical signals with the following parameters; a signal frequency of 30 Hz or less, particularly 15 Hz or less, a current magnitude of not above 3 mA, in particular, not above 1 mA, a stimulation signal on-time to signal off-time ratio in the range of about 2;
1 to about 1;
2, and signal on-times and off-times in the range of about 10 seconds to about 5 minutes, anda pulse width within the range of 50 μ
s to 500 μ
s. - View Dependent Claims (2, 3, 4, 5)
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6. A method for manufacturing a neurostimulator system intended for alleviating cerebellar tremor associated with multiple sclerosis, comprising:
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providing a programmable electrical pulse generator; programming the programmable electrical pulse generator to generate electrical signals effective to control cerebellar tremor when said signals are applied to a cranial nerve of a patient suffering from cerebellar tremor; and providing at least one electrode connected with the programmable electrical pulse generator for applying the electrical signals generated by the electrical pulse generator to a cranial nerve for controlling cerebellar tremor. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of treating a patient suffering from cerebellar tremor, comprising:
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providing a neurostimulator system comprising a programmable electrical pulse generator comprising at least one electrode for applying electrical signals generated by the electrical pulse generator, wherein said pulse generator is programmed with signal parameters comprising a pulse width and/or a current magnitude and/or a pulse frequency and/or stimulation on-time and/or stimulation off-time effective to attenuate or control cerebellar tremor in the patient; placing said electrode in electrical communication with a cranial nerve of the patient; and applying said electrical signals to said cranial nerve by means of the at least one electrode, effective to attenuate or control the cerebellar tremor. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22)
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23. A computer program product, comprising one or more computer readable media having computer-executable instructions for controlling a programmable electrical pulse generator to generate electrical signals with
a current magnitude in the range of from about 1 mA to about 2 mA, a stimulation signal on-time to signal off-time ratio in the range of about 2: - 1 to about 1;
2, and signal on-times and off-times in the range of about 10 seconds to about 5 minutes,a signal frequency below 30 Hz, and a pulse width within the interval of from about 50 μ
s to about 500 μ
s.
- 1 to about 1;
Specification