LEAD COMPRISING A DRUG REGION SHARED BY MORE THAN ONE ELECTRODE

• US 20080027526A1
• Filed: 07/27/2006
• Published: 01/31/2008
• Est. Priority Date: 07/27/2006
• Status: Abandoned Application

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zarembo, Paul E.
• Application Number:
  US11/460,429
• Publication Number:
  US 20080027526A1
• Time in Patent Office: Days
• US Class Current: 607/120
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/0568 with drug delivery
• CPC Class Codes: A61N 1/0575 with drug delivery

Abstract

One or more multi-electrode lead couplable with a medical device, such as an implantable medical device. Each lead includes a lead body extending from a lead proximal end portion to a lead distal end portion. The proximal end portion includes a connector assembly for connection to the medical device. An intermediate or distal end portion includes two or more electrodes and a drug region shared by at least two of the electrodes. In one example, the drug region is positioned between two or more electrodes such each of the electrodes may benefit from a drug in the region. In another example, the medical device comprises circuitry adapted to sense a heart in a first instance and stimulate the heart in a second instance using a selected electrode configuration. A method of forming a lead having a drug region shared by more than one electrode is also discussed.

Claims

1. A lead comprising:

a lead body extending from a lead proximal end portion to a lead distal end portion, and having a lead intermediate portion therebetween;

an electrical connector assembly coupled to the lead proximal end portion;

at least a first and a second electrode disposed along the lead body, the electrodes electrically coupled to the connector assembly by way of one or more longitudinally extending conductors; and

a drug region disposed between the first and the second electrodes, the drug region configured to be shared by the electrodes.

2. The lead of claim 1, wherein the drug region extends from a first end to a second end, the first end being between about 0-about 0.250″

from the first electrode and the second end being between about 0-about 0.250″

from the second electrode.

3. The lead of claim 1, further comprising a structural strength of fixation mechanism disposed on the lead body near an edge of the drug region.

4. The lead of claim 1, wherein the drug region comprises a polymeric material mixed with a drug.

5. The lead of claim 4, wherein the drug is dispersed through the polymeric material and a combination thereof is formed into a solid shape couplable with the lead body.

6. The lead of claim 1, wherein the drug region comprises a drug eluting matrix that elutes one or more drugs over time.

7. The lead of claim 6, wherein the drug eluting matrix comprises at least one drug and at least one drawing agent, the drawing agent having the ability to draw bodily fluid into the matrix for modulating a drug delivery rate of the at least one drug to nearby bodily tissue.

8. The lead of claim 1, wherein the lead body comprises a preformed bias portion at one or both of the lead intermediate or the lead distal end portion.

9. The lead of claim 8, wherein the preformed bias portion urges one or more of the first electrode, the second electrode, or the shared drug region against a vessel wall, a septal wall, a heart wall, a pulmonary trunk wall, or a pulmonary artery wall.

10. The lead of claim 8, wherein the preformed bias portion comprises at least one of a helical or sinusoidal shape.

11. A cardiac system including the lead of claim 1, coupled with a medical device via the electrical connector assembly, wherein the medical device comprises an electronics circuit configured to generate one or both of a sense signal or a stimulation signal.

12. The cardiac system of claim 11, wherein the sense or stimulation signal are delivered using one or both of the first or second electrode.

13. The cardiac system of claim 12, wherein the medical device further comprises a processing circuit adapted to select the delivering electrode using, at least in part, one or a combination of a stimulation threshold parameter, a stimulation impedance parameter, a stimulation selection parameter, a heart chamber configuration parameter, or a spatial distance parameter.

14. An implantable lead for use with an implantable medical device, the implantable lead comprising:

a lead body extending from a proximal end to a distal end and having at least one elongated electrical conductor contained therewithin and extending between the proximal end and the distal end;

two or more electrodes disposed on the lead body and electrically coupled with the at least one conductor; and

a drug region positioned directly adjacent the two or more electrodes, the drug region configured to dispense a drug to the electrodes.

15. The implantable lead of claim 14, wherein the drug region is positioned between the two or more electrodes.

16. The implantable lead of claim 15, wherein the drug region includes a fixation mechanism.

17. The implantable lead of claim 14, wherein the two or more electrodes comprises a first, a second, a third, and a fourth electrode;

and

wherein a first drug region is positioned between the first and second electrodes and a second drug region is positioned between the third and fourth electrodes.

18. The implantable lead of claim 17, wherein one or both of the first and second electrodes or the third and fourth electrodes are electrically coupled providing an increased effective electrode surface area.

19. The implantable lead of claim 18, wherein the electrical coupling comprises a hard connection between the electrodes or a software connection programmed in an electrically coupled medical device.

20. A method comprising:

forming a lead body encasing a substantial portion of one or more electrical conductors, including forming a lead body extending from a proximal end portion to a distal end portion and having an intermediate portion therebetween;

disposing a first electrode on the lead body near the lead intermediate or distal end portion;

disposing a second electrode on the lead body a selected distance away from the first electrode; and

disposing a drug region on the lead body in a position such that the drug is shared by the first and second electrodes.

21. The method of claim 20, wherein disposing the drug region on the lead body includes disposing the drug region on a portion of the lead body between the first and second electrodes, such that the electrodes straddle the drug region.

22. The method of claim 20, wherein disposing the drug region on the lead body includes spraying, dipping, or painting the drug on the lead body.

23. The method of claim 20, wherein disposing the drug region on the lead body includes impregnating a porous medium with drug on the lead body.

24. The method of claim 20, wherein disposing the drug region on the lead body includes fusing a drug ring to the lead body.

25. The method of claim 20, further comprising electrically coupling the first and second electrodes to provide an increased effective electrode surface area.

26. The method of claim 20, wherein forming the lead body includes forming a bias portion at or near the lead intermediate or distal end portion.

27. The method of claim 20, further comprising disposing a third and a fourth electrode on the lead body, and a drug region therebetween.