Injectables in foam. New Pharmaceutical applications

• US 20080031827A1
• Filed: 07/16/2007
• Published: 02/07/2008
• Est. Priority Date: 08/08/2001
• Status: Active Grant

• Current Assignee: Biocompatibles Incorporated (Boston Scientific Corporation)
• Original Assignee: BTG International Limited (Boston Scientific Corporation)
• Inventors: Garcia-Olmedo Dominguez, Maria
• Granted Patent: US 8,512,680 B2
• Time in Patent Office: Days
• US Class Current: 424/43
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/122 Foams; Dry foams edible foams A61K9/0056
• CPC Class Codes: A61P 9/00 Drugs for disorders of the cardiovascular system

Abstract

The placing of a drug that is suitable for parenteral administration on bubbles formed with sterile gases produces an exponential increase in its active surface area with a decrease in the diameter of the bubble, modifies the kinetics of its distribution and, thanks to its micronisation, increases its therapeutic effect. Furthermore, the echogenicity of the bubbles allows us to follow them on ultrasound after their injection, so that we can visualise the medicament and, thanks to its steerability, can direct it to the selected site or prevent it from reaching undesired areas. This pharmaceutical form is of interest in the treatment of diseases that require a greater local action of the injected drugs than can be achieved with the pharmaceutical forms in current use.

Claims

1. PHARMACEUTICAL FORM OF INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, characterized to include any medicinal substance or drug other than sclerosing agents as well as FOAM FOR INJECTABLES formed with inert foaming agents and any gas.

2. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is a vasodilator.

3. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance acts on the cardiovascular system.

4. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is an antimycotic.

5. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is an anti-infectious agent.

6. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is an antibiotic including trimethoprim.

7. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is any other antibiotic or chemotherapeutic agent.

8. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is a sulphonamide.

9. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is a cytostatic.

10. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is an anaesthetic.

11. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is an anti-inflammatory.

12. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is a prostaglandin.

13. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is a corticosteroid.

14. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance has hormonal action.

15. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that the medicinal substance is an antiviral agent.

16. INJECTABLE FOAM, both already prepared and as an extemporaneous preparation, in accordance with claim 1, characterized in that it is formed with inert foaming agents and any gas.