Combination consisting of a magnesium preparation having a prolonged release and of another active substance, and use thereof in the fields of cosmetics, therapeutics and/or nutrition

• US 20080031904A1
• Filed: 11/23/2005
• Published: 02/07/2008
• Est. Priority Date: 05/27/2003
• Status: Abandoned Application

• Current Assignee: Fabienne Menvielle-Bourg-Joanny
• Original Assignee: Fabienne Menvielle-Bourg-Joanny
• Inventors: Menvielle-Bourg-Joanny, Fabienne
• Application Number:
  US11/286,192
• Publication Number:
  US 20080031904A1
• Time in Patent Office: Days
• US Class Current: 424/401
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61K 33/08 Oxides; Hydroxides
• CPC Class Codes: A61K 33/14 Alkali metal chlorides; Alkaline earth metal chlorides
• CPC Class Codes: A61P 3/02 Nutrients, e.g. vitamins, minerals

Abstract

The present invention relates to a combination useful in the fields of cosmetics, therapeutics and/or nutrition, for acting in particular against stress conditions, characterised in that it consists of (α) a sustained release preparation (I) comprising, in association with a physiologically acceptable excipient, a mixture of: (A) magnesium derived from a magnesium source consisting of MgO, MgCl₂ and hydrates of the formula MgCl₂·nH₂O, where n is a whole or fractional number greater than 0 or equal to 6, (B) at least one substance selected from among (B1) a hydrophilic polymer, which is a cellulose derivative, and/or (B2) a hydrophobic substance belonging to the family of fatty acid esters and the mixtures thereof, and (C) an inert filler acting as diluent, in particular lactose; and (β) an active substance (Z), which is in particular selected from among plant extracts, yeast extracts, algae extracts, hormones, proteins, peptides, amino acids, unsaturated fatty acids and mixtures thereof.

Claims

1. A combination useful in the fields of cosmetics, therapeutics and/or nutrition, for acting in particular against stress conditions, characterised in that it consists of

(α

) a sustained release magnesium preparation (I) comprising, in association with a physiologically acceptable excipient, a mixture of;

(A) magnesium derived from a magnesium source consisting of MgO, MgCl₂ and hydrates of the formula MgCl₂·

nH₂O, where n is a whole or fractional number greater than 0 or equal to 6,

(B) at least one substance selected from among B1, B2 or a combination thereof;

(B1) a hydrophilic polymer, which is a cellulose derivative, and/or

(B2) a hydrophobic substance belonging to the family of fatty acid esters with polyols, and

(C) an inert filler acting as diluent, in particular lactose, the magnesium content being between 1 and 60% by weight relative to the weight of said mixture A+B+C; and

,

(β

) an active substance (Z), which is selected from the group consisting of;

natural plant extracts,

yeasts and yeast extracts,

algae extracts,

hormones,

proteins, in particular enzymes,

peptides,

amino acids,

unsaturated fatty acids, and

mixtures thereof.

2. A combination according to claim 1, wherein said mixture of A, B and C forms a sustained release core which is capable of being accommodated inside a gastroresistant coating, of the film coating type.

3. A magnesium-based combination according to claim 1, wherein said active substance (Z) is capable of replacing a portion of the magnesium contained in said preparation (I).

4. A combination according to claim 1, wherein said preparation (I) and said active substance (Z) comprise distinct dosage forms for separate administration.

5. A combination according to claim 1, wherein said preparation (1) and said active substance (Z) are in the same dosage form.

6. A combination according to claim 4, wherein (i) said preparation (I) is in the form of an oral dosage form comprising a core containing A, B and C and which is capable of being accommodated inside a gastroresistant coating, and in that (ii) said active substance (Z) is in the form of a topical dosage form.

7. A combination according to claim 5, wherein said preparation (I) and said active substance (Z) are in the same dosage form, said active substance (Z) being incorporated

(i) in the core containing A, B and C,

(ii) in the shell provided by the gastroresistant coating of said preparation (I),

(iii) in a non-gastroresistant layer surrounding the core containing A, B and C, or

(iv) in a layer surrounding said gastroresistant coating.

8. A combination according to claim 1, wherein in said preparation (I):

the weight ratio of B;

A is between 0.8;

1 and 8.2;

1 (preferably between 1.2;

1 and 4.8;

1),

the weight ratio of C;

A is between 0.4;

1 and 4;

1 (preferably between 0.5;

1 and 2.3;

1), and

the quantity of Mg per dosage unit, in particular in the form of a tablet, varies between 10 mg/dosage unit and 250 mg/dosage unit, the preferred dosages of Mg being 30 mg/dosage unit, 50 mg/dosage unit or 100 mg/dosage unit.

9. A combination according to claim 1, wherein said substance (Z) is selected from the group consisting of hawthorn extract, valerian extract, balm extract, sea thyme extract, maritime pine bark extract, lime tree sapwood extract, cereal extracts (in particular wheat and/or rice protein hydrolysate), soya extract or a mixture thereof.

10. A combination according to 1, wherein said substance (Z) is selected from the group consisting of fruit extracts (in particular apple extract, melon extract, papaya extract, pineapple extract), yeast extract, algae extract or a mixture thereof.

11. A combination according to claim 1, wherein said substance (Z) is selected from the group consisting of hormones, proteins, peptides, amino acids, or a mixture thereof.

12. A combination according to claim 1, wherein said substance (Z) is selected from the group consisting of C₁₂-C₂₄ unsaturated fatty acids, in particular oleic acid, linoleic acid, linolenic acid, an ω

³ acid, an ω

⁶ acid or a mixture thereof.

13. Use of the combination according to claim 1, wherein in the field of cosmetics, in the field of dermatotherapeutics and/or in the field of nutrition.