Methods and devices for reducing or blocking blood flow to a selected blood vessel or part thereof

• US 20080033341A1
• Filed: 08/06/2007
• Published: 02/07/2008
• Est. Priority Date: 08/04/2006
• Status: Abandoned Application

• Current Assignee: Bay Holdings Ltd.
• Original Assignee: Bay Holdings Ltd.
• Inventors: Grad, Ygael
• Application Number:
  US11/882,813
• Publication Number:
  US 20080033341A1
• Time in Patent Office: Days
• US Class Current: 604/20
• CPC Class Codes: A61B 18/24 with a catheter A61B18/26, A61B18/28 take precedence
• CPC Class Codes: A61B 18/245 for removing obstructions in blood vessels or calculi
• CPC Class Codes: A61B 2018/2238 with means for selectively laterally deflecting the tip of the fibre
• CPC Class Codes: A61M 25/00 Catheters; Hollow probes dilators A61M29/00; peritoneal catheters A61M1/285; tracheal tubes A61M16/04; for drainage A61M27/00; for uterus, vagina or rectum A61M31/00 ; for measuring or testing A61B; materials for catheters A61L29/00
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A method of reducing or blocking blood to a selected blood vessel or a selected part of the wall thereof, particularly for treating an aneurysm, an arteriovenous or dural malformation in a blood vessel, or for devascularizing tumors, by deploying in the blood vessel an expandable member having a contracted condition for manipulation within the blood vessel, and expandable to an expanded condition in the blood vessel for reducing or blocking blood flow through the selected part thereof, thereby promoting coagulation of blood therein, and for preventing thrombus material from being swept downstream, and applying a local stimulus to the interior of the malformation effective to initiate or accelerate coagulation of blood therein. In some described embodiments, the expandable member is a permeable mesh-like tube of biocompatible material, and in other described embodiments, the expandable member is an inflatable balloon.

Claims

1. A method of reducing or blocking blood flow to a selected blood vessel, or a selected part of a wall thereof, particularly for treating an aneurysm, an arteriovenous malformation, or a dural malformation, or for devascularizing a blood vessel feeding the tumor, such method comprising:

deploying in the selected blood vessel an expandable member having a contracted condition for manipulation within the blood vessel, and expandable to an expanded condition in the blood vessel for reducing or blocking blood flow through the blood vessel or the selected part of the wall thereof, and thereby to promote coagulation of blood within the selected blood vessel or part of the wall thereof;

and applying a local stimulus to the interior of the selected blood vessel or part of the wall thereof effective to initiate or accelerate coagulation of blood therein.

2. The method according to claim 1, wherein said expandable member is a permeable mesh-like tube of biocompatible material dimensioned, when expanded, to straddle the selected part of the blood vessel wall such as to reduce blood flow thereto, and also to prevent thrombus from being swept downstream thereof.

3. The method according to claim 1, wherein said expandable member is an inflatable balloon effective, when inflated, to block blood flow to the selected blood vessel or selected part of the wall thereof, and to prevent thrombus from being swept downstream thereof.

4. The method according to claim 3, wherein said inflatable balloon is effective, when inflated, to straddle the opposite sides of the selected part of the blood vessel or wall thereof.

5. The method according to claim 3, wherein said inflatable balloon is deployed downstream of the selected part of the blood vessel or wall thereof when inflated.

6. The method according to claim 1, wherein said local stimulus is light energy applied by an optical fiber having a tip deployed in the selected part of the blood vessel in which coagulation is to be initiated or accelerated.

7. The method according to claim 6, wherein a light-energy absorption agent is applied to the interior of said selected part of the blood vessel before said light energy is applied thereto.

8. The method according to claim 6, wherein said expandable member is a permeable mesh-like tube of biocompatible material dimensioned, when expanded, to straddle the selected part of the blood vessel wall such as to reduce blood flow thereto;

and wherein said optical fiber tip is deployed in the selected part of the blood vessel where coagulation is to be initiated or accelerated, after the partial deployment of the permeable mesh-like tube in said blood vessel.

9. The method according to claim 6, wherein said expandable member is a permeable mesh-like tube of biocompatible material dimensioned, when expanded, to straddle the selected part of the blood vessel wall such as to reduce blood flow thereto;

and wherein said optical fiber tip is deployed in the selected part of the blood vessel where coagulation is to be initiated or accelerated, before the full deployment of the permeable mesh-like tube in said blood vessel.

10. The method according to claim 6, wherein said expandable member is a permeable mesh-like tube of biocompatible material dimensioned, when expanded, to straddle the selected part of the blood vessel such as to reduce blood flow thereto;

and wherein said optical fiber tip is deployed in the selected part of the blood vessel where coagulation is to be initiated or accelerated, after the full deployment of the permeable mesh-like tube in said blood vessel.

11. The method according to claim 6, wherein said expandable member is a permeable mesh-like tube of biocompatible material dimensioned, when expanded, to straddle the selected part of the blood vessel such as to reduce blood flow thereto;

and wherein said permeable mesh-like tube is an expansible tube having an initial contracted state for enabling moving the tube to the site of deployment in the blood vessel, and an expanded state for fixing the tube within the blood vessel.

12. The method according to claim 1, wherein:

said permeable mesh-like tube, while in the contracted state, is moved through the blood vessel to a position wherein its opposite sides straddle the selected part of the blood vessel in which the coagulation is to be initiated or accelerated;

the side of the permeable mesh-like tube facing the downstream direction is expanded;

the optic fiber tip is deployed into the selected part of the blood vessel wall in which coagulation is to be initiated or accelerated;

and then light energy is applied to the optical fiber to cause its tip to initiate or accelerate coagulation of blood therein while the permeable mesh-like tube prevents emboli resulting from said coagulation from moving through the blood vessel in the downstream direction.

13. The method according to claim 12, wherein the side of the permeable mesh-like tube facing the upstream direction is expanded after the deployment of the optical fiber tip in said selected part of the blood vessel.

14. The method according to claim 1, wherein:

said permeable mesh-like tube, while in the contracted state, is moved through the blood vessel to a position wherein its opposite sides straddle the opposite sides of the selected part of the blood vessel in which coagulation is to be initiated or accelerated;

said optic fiber tip is deployed into the selected part of the blood vessel where coagulation is to be initiated or accelerated, by moving the optical fiber between the outer surface of the permeable mesh-like tube and the inner surface of the blood vessel;

said permeable mesh-like tube is then expanded to fix it within the blood vessel straddling the selected part of the blood vessel;

and light energy is then applied to the optical fiber to initiate or accelerate coagulation of the blood within the selected part of the blood vessel wall, while the permeable mesh-like tube prevents emboli resulting from said coagulation from moving through the tube into the blood vessel.

15. The method according to claim 11, wherein

said permeable mesh-like tube, while in the contracted state, is moved through the blood vessel to a position wherein its opposite sides straddle the selected part of the blood vessel in which the coagulation is to be initiated or accelerated;

the permeable mesh-like tube is expanded to fix it within the blood vessel and;

said optical fiber tip is then deployed by moving the optical fiber through the interior of the expanded permeable mesh-like tube with its tip passing through the permeable mesh-like tube into said selected part of the blood vessel where coagulation is to be initiated or accelerated.

16. The method according to claim 6, wherein said optical fiber tip is deployed into said selected part of the blood vessel via a microcatheter.

17. The method according to claim 16, wherein said microcatheter for deploying said optical fiber tip into said selected part of the blood vessel is also used for applying a light-energy absorption agent into said selected part of the blood vessel before applying said light energy thereto.

18. The method according to claim 11, wherein said permeable mesh-like tube includes an outer sheath normally constraining the permeable mesh-like tube to its contracted state, which sheath is removable to permit the tube to expand to its expanded state.

19. The method according to claim 10, wherein said optical fiber tip includes a surface on its end and lateral sides for diffusing light energy around said tip.

20. The method according to claim 19, wherein said light energy is laser energy.

21. The method according to claim 1, wherein said local stimulus is a pharmacological agent which induces thrombosis.

24. The method according to claim 1, wherein said expandable member is an inflatable balloon effective, when inflated, to block blood flow to the selected blood vessel or selected part of the wall thereof.

29. A microcatheter particularly useful in the method of claim 1, said microcatheter comprising:

an optical fiber having a tip including diffusive surfaces on its end and lateral sides for emitting light energy around the tip;

a catheter tube enclosing said optical fiber for deploying said optical fiber tip into the selected part of the blood vessel in which coagulation is to be initiated or accelerated;

and an applicator for delivering to the interior of said selected part of the blood vessel, before said light energy is applied thereto, a light-energy absorption agent via space between said optic fiber and said catheter tube.

22. A kit for use in reducing or blocking blood flow to a selected blood vessel, or a selected part or a wall thereof, particularly for treating an aneurysm, an arteriovenous malformation, or a dural malformation, or for devascularizing a blood vessel feeding a tumor, said kit comprising:

an expandable member having a contracted condition for manipulation within the blood vessel and expandable to an expanded condition within the blood vessel for reducing or blocking blood flow to the selected part of the blood vessel or wall thereof, and thereby to promote coagulation of blood therein;

and a local stimulus applicator for applying a local stimulus to the interior of the selected part of the blood vessel, such as to initiate or accelerate coagulation of blood therein.

23. The kit according to claim 22, wherein said expandable member is a permeable mesh-like tube of biocompatible material dimensioned, when expanded, to straddle the selected part of the blood vessel or wall thereof, such as to reduce blood flow thereto.

25. The kit according to claim 22, wherein said local stimulus applicator is an optical fiber having a tip to be located within said selected part of the blood vessel in which coagulation is to be initiated or accelerated.

26. The kit according to claim 25, further including a microcatheter for deploying said optical fiber tip.

27. The kit according to claim 26, wherein said microcatheter comprises:

an optical fiber having a tip including diffusive surfaces on its end and lateral sides for emitting light energy around the tip;

a catheter tube enclosing said optical fiber for deploying said optical fiber tip into the selected part of the blood vessel in which coagulation is to be initiated or accelerated;

and an applicator for delivering to the interior of said selected part of the blood vessel, before said light energy is applied thereto, a light-energy absorption agent via space between said optic fiber and said catheter tube.

28. The microcatheter according to claim 27, wherein said optical fiber includes a convex diffusive cap at said tip.

30. The microcatheter according to claim 28, wherein said optical fiber includes a convex diffusive cap at said tip.