Membranes with controlled permeability to polar and apolar molecules in solution and methods of making same
First Claim
1. A membrane having controlled permeability to polar and non-polar solutes, for use in an implantable sensor, comprising different first and second polymers, the first polymer comprising at least one crosslinked substantially hydrophobic polymer and the second polymer comprising at least one crosslinked substantially hydrophilic polymer;
- wherein the hydrophobic and hydrophilic polymers are present in a ratio from between about 50;
50 to 5;
95, and form an interpenetrating polymer network, semi- interpenetrating polymer network or polymer blend; and
wherein further the membrane is characterized by a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen).
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Accused Products
Abstract
A membrane for use in an implantable glucose sensor including at least one crosslinked substantially hydrophobic polymer and at least one crosslinked substantially hydrophilic polymer; wherein the first and second polymers are different polymers and substantially form an interpenetrating polymer network, semi- interpenetrating polymer network, polymer blend, or copolymer. The membranes are generally characterized by providing a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). Three methods of making membranes from hydrophobic and hydrophilic monomers formed into polymer networks are provided, wherein according to at least two of the methods, the monomers may be substantially immiscible with one another.
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Citations
44 Claims
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1. A membrane having controlled permeability to polar and non-polar solutes, for use in an implantable sensor, comprising different first and second polymers, the first polymer comprising at least one crosslinked substantially hydrophobic polymer and the second polymer comprising at least one crosslinked substantially hydrophilic polymer;
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wherein the hydrophobic and hydrophilic polymers are present in a ratio from between about 50;
50 to 5;
95, and form an interpenetrating polymer network, semi- interpenetrating polymer network or polymer blend; andwherein further the membrane is characterized by a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 36, 39, 41)
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29. An implantable glucose sensor comprising:
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(A) a glucose sensor body; (B) at least one membrane disposed on the glucose sensor body comprising a solvent swellable polymeric material comprising hydrophilic polymer component and hydrophobic polymer component; wherein the membrane is characterized by a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). - View Dependent Claims (30)
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31. An implantable glucose sensor comprising:
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(A) a glucose sensor body; (B) at least one membrane disposed on the glucose sensor body comprising a solvent soluble polymeric material comprising hydrophilic polymer component and hydrophobic polymer component; wherein the membrane is characterized by a permeability ratio of oxygen to glucose of about 1 to about 1000 in units of (mg/dl glucose) per (mmHg oxygen). - View Dependent Claims (32)
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33. A method of making membranes having controlled permeability to oxygen and glucose, comprising:
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(a) providing a hydrophobic polymer membrane, a hydrophobic monomer, and at least one silylated hydrophilic monomer; (b) combining the hydrophobic and hydrophilic monomers to form a mixture; (c) impregnating the hydrophobic polymer membrane with the monomer mixture; (d) polymerizing the monomers; and (e) desilylating the polymerized hydrophilic monomer, wherein at least one cross-linking agent is provided separately to each of the monomers in step (a), or to the mixture of monomers in step (b), to form an interpenetrating or semi-interpenetrating polymer network, or polymer blend. - View Dependent Claims (34, 35, 42)
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37. A method of making membranes having controlled permeability to oxygen and glucose, comprising:
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(a) providing a mixture of at least one hydrophobic monomer and at least one silylated hydrophilic monomer; (b) placing the mixture into a cavity of a membrane mold; (d) polymerizing the monomers in the mixture; and (d) desilylating the polymerized hydrophilic monomer, wherein at least one cross-linking agent is provided to the mixture of monomers in step (a) to form an interpenetrating or semi-interpenetrating polymer network of the monomers, or a polymer blend, or a copolymer. - View Dependent Claims (38, 43)
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40. A method of making membranes having controlled permeability to oxygen and glucose, comprising:
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(a) providing a solution of at least one non-silylated hydrophobic monomer including siloxane linkages in the polymer backbone, at least one non-silylated hydrophilic monomer including acrylate linkages in the polymer backbone, at least one polymerization initiator and a solvent compatible with the hydrophobic and hydrophilic monomers, wherein none of the monomers present in the solution is silylated; (b) allowing the monomers in the solution to polymerize; and (c) allowing the solvent to evaporate, wherein at least one cross-linking agent is provided to the solution of monomers in step (a) to form a polymer solution in step (b). - View Dependent Claims (44)
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Specification