Liquid delivery system

• US 20080035667A1
• Filed: 04/25/2007
• Published: 02/14/2008
• Est. Priority Date: 06/07/2006
• Status: Abandoned Application

• Current Assignee: ViroPharma Inc. (Shire plc)
• Original Assignee: OSG Norwich Pharmaceuticals, Inc.
• Inventors: Valenti, Michael J.
• Application Number:
  US11/789,652
• Publication Number:
  US 20080035667A1
• Time in Patent Office: Days
• US Class Current: 222/1
• CPC Class Codes: A61J 3/07 into the form of capsules or similar small containers for oral use

Abstract

A liquid supply system supplies liquid to a hopper upon liquid within the hopper reaching a low liquid level. The liquid may be heated within a liquid reservoir and within a liquid conduit between the reservoir and the hopper.

Claims

1. An apparatus for delivering a liquid to a hopper, the apparatus comprising:

A heated liquid reservoir;

a hopper;

a liquid level sensor structured to measure a level of liquid within the hopper;

a valve operatively connected to the liquid level sensor; and

a heated liquid flow path in communication with the liquid reservoir and the hopper, the valve being structured to selectively open and close the liquid flow path;

whereby the sensor causes the valve to permit liquid to flow into the hopper upon liquid within the hopper reaching a first predetermined liquid level, and resists any flow of liquid into the hopper upon the liquid level within the hopper reaching a second predetermined level.

2. The apparatus according to claim 1, wherein the liquid is heated to a temperature of about 68°

C. (154°

F.).

3. The apparatus according to claim 1, wherein the liquid flow path comprises:

a first liquid conduit leading from the liquid reservoir to the three way valve;

a second liquid conduit leading from the three way valve to the hopper;

a third liquid conduit leading from the three way valve to the liquid reservoir; and

a pump disposed along the first liquid conduit;

whereby liquid is recirculated between the valve and liquid reservoir when the level of liquid is above a first predetermined level, and liquid is dispensed from the three way valve to the hopper when the level of liquid falls below the first predetermined level until the level of liquid reaches a second predetermined level.

4. The apparatus according to claim 3, wherein the liquid reservoir is heated.

5. The apparatus according to claim 4, wherein the first liquid conduit, second liquid conduit, and third liquid conduit are heated.

6. The apparatus according to claim 5, wherein the first liquid conduit, second liquid conduit, and third liquid conduit include heating elements therein.

7. The apparatus according to claim 5, wherein the pump is heated.

8. The apparatus according to claim 7, wherein the pump is heated by a blanket having a heating element substantially surrounding the pump.

9. The apparatus according to claim 5, wherein the three way valve is heated.

10. The apparatus according to claim 19, wherein the three way valve is heated by a blanket having a heating element substantially surrounding the pump.

11. The apparatus according to claim 1, wherein the liquid reservoir is disposed above the hopper, and the liquid flow path is structured to permit liquid to flow from the reservoir to the hopper due to gravity.

12. The apparatus according to claim 11, wherein the liquid reservoir is heated.

13. The apparatus according to claim 12, wherein the liquid flow path is heated.

14. The apparatus according to claim 13, wherein the liquid flow path includes heating elements therein.

15. The apparatus according to claim 1, wherein the liquid reservoir is pressurized;

whereby the pressurization biases the liquid towards the liquid flow path.

16. The apparatus according to claim 15, wherein the liquid reservoir is heated.

17. The apparatus according to claim 16, wherein the liquid flow path is heated.

18. The apparatus according to claim 17, wherein the liquid flow path includes heating elements therein.

19. The apparatus according to claim 1, wherein the second predetermined level is higher than the first predetermined level.

20. The apparatus according to claim 1, wherein the hopper is structured to feed the liquid to an encapsulator.

21. The apparatus according to claim 1, wherein the liquid comprises a formulation of propylene glycol or polyethylene glycol.

22. The apparatus according to claim 21, wherein the liquid comprises a pharmaceutically active agent.

23. The apparatus according to claim 22, wherein the pharmaceutically active agent is selected from the group consisting of antibiotics, analgesics, and antivirals.

24. The apparatus according to claim 23, wherein the pharmaceutically active agent is vancomycin.

25. The apparatus according to claim 24, wherein the liquid comprises a suspension of vancomycin HCl and polyethylene glycol.

26. The apparatus according to claim 25, wherein a temperature of the liquid is maintained between about 60°

C. to about 70°

C.

27. The apparatus according to claim 26, wherein the temperature of the liquid is maintained at about 68°

C.

28. The apparatus according to claim 1, further comprising an agitator within the liquid reservoir.

29. A method of delivering a liquid to a hopper, the method comprising:

providing a liquid reservoir, a hopper, and a liquid flow path from the liquid reservoir to the hopper;

measuring a level of liquid within the hopper;

dispensing liquid into the hopper when the level of liquid falls below the first predetermined level until the level of liquid reaches a second predetermined level; and

wherein the liquid comprises a pharmaceutically active agent.

30. The method according to claim 29, further comprising heating the liquid reservoir.

31. The method according to claim 29, further comprising heating the liquid flow path.

32. The method according to claim 29, further comprising agitating the liquid within the liquid reservoir and within the hopper.

33. The method according to claim 29, further comprising recirculating a liquid between the liquid reservoir and the hopper when the level of liquid is above a first predetermined level.

34. The method according to claim 29, wherein the second predetermined level is higher than the first predetermined level.

35. The method according to claim 29, further comprising feeding the liquid from the hopper to an encapsulator.

36. The method according to claim 29, wherein the liquid comprises a formulation of propylene glycol or polyethylene glycol.

37. The method according to claim 29, wherein the pharmaceutically active agent is selected from the group consisting of antibiotics, analgesics, and antivirals.

38. The method according to claim 37, wherein the pharmaceutically active agent is vancomycin.

39. The method according to claim 38, wherein the liquid comprises a suspension of vancomycin HCl and polyethylene glycol.

40. The method according to claim 39, wherein a temperature of the liquid is maintained between about 60°

C. to about 70°

C.

41. The method according to claim 29, wherein the temperature of the liquid is maintained at about 68°

C.