Method For Producing Protein Adsorption-Preventing Ocular Lens Material

• US 20080038221A1
• Filed: 05/18/2005
• Published: 02/14/2008
• Est. Priority Date: 05/24/2004
• Status: Active Grant

• Current Assignee: Kazuhiko Ishihara, Shiseido Company Limited
• Original Assignee: Kazuhiko Ishihara, Shiseido Company Limited
• Inventors: Ishihara, Kazuhiko, Suda, Yukimitsu, Miyazawa, Kazuyuki
• Granted Patent: US 8,277,834 B2
• Time in Patent Office: Days
• US Class Current: 424/78.04
• CPC Class Codes: A61F 2/16 Intraocular lenses
• CPC Class Codes: C08J 7/12 Chemical modification
• CPC Class Codes: G02B 1/043 Contact lenses

Abstract

The present invention is a method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material wherein a chemical compound having an end amino group is introduced to said eye lens material and then the chemical compound represented by the following formula (2) or (3) is introduced through said chemical compound having an end amino group.
The object of the present invention is to provide a method of manufacturing a contact lens that prevents protein adsorption.
n denotes a natural number 1-18.

Claims

1. A method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material, wherein:

a chemical compound having an end amino group is introduced to said eye lens material, and then

the phosphorylcholine group-containing chemical compound represented by the following formula (2) is introduced through said chemical compound having an end amino group;

wherein n denotes a natural number 1-18.

3. The method of manufacturing an eye lens material as described in claim 1, wherein said chemical compound having an end amino group is a chemical compound having an alkyl group of C0(hydrazine)-C12, an ethylene oxide group with a degree of polymerization of 1-10, a propyleneoxide group with a degree of polymerization of 1-10, an ethyleneimine with a degree of polymerization of 1-20, or a propyleneimine with a degree of polymerization of 1-20, or a chemical compound having aniline, or piperazine.

4. A protein adsorption prevention method for an eye lens material, wherein protein adsorption on the eye lens material is prevented by covalently bonding phosphorylcholine groups onto the eye lens material surface by means of an after-treatment in which a chemical compound having an end amino group is introduced onto the surface of the eye lens material, and then the phosphorylcholine group-containing chemical compound of said formula (2) of claim 1 is reacted with the eye lens material.

5. A protein adsorption prevention method for an eye lens material, wherein protein adsorption on the eye lens material is prevented by covalently bonding phosphorylcholine groups onto the eye lens material surface by means of an after-treatment in which amino groups are introduced to the phosphorylcholine group-containing chemical compound of said formula (2) of claim 1, which is then reacted with the eye lens material.

6. An eye lens material, wherein a spacer is introduced by means of amide bonding or alkylamine bonding between the surface of the eye lens material and the chemical compound having a phosphorylcholine group of said formula (2) of claim 1 to be introduced.

2. A method of manufacturing an eye lens material having a process in which a phosphorylcholine group-containing chemical compound represented by the following formula (1) is reacted and covalently bonded onto the surface of an eye lens material, wherein:

a chemical compound having an end amino group is introduced to the surface of said eye lens material, and then

the phosphorylcholine group-containing chemical compound represented by the following formula (3) is introduced through said chemical compound having an end amino group;

7. The method of manufacturing an eye lens material as described in claim 2, wherein said chemical compound having an end amino group is a chemical compound having an alkyl group of C0(hydrazine)-C12, an ethylene oxide group with a degree of polymerization of 1-10, a propyleneoxide group with a degree of polymerization of 1-10, an ethyleneimine with a degree of polymerization of 1-20, or a propyleneimine with a degree of polymerization of 1-20, or a chemical compound having aniline, or piperazine.

8. The protein adsorption prevention method for an eye lens material of claim 4, wherein the phosphorylcholine group-containing chemical compound is represented by formula (3) of claim 2.

9. The protein adsorption prevention method for an eye lens material of claim 5, wherein the phosphorylcholine group-containing chemical compound is represented by formula (3) of claim 2.

10. An eye lens material, wherein a spacer is introduced by means of amide bonding or alkylamine bonding between the surface of the eye lens material and the chemical compound having a phosphorylcholine group of said formula (3) of claim 2 to be introduced.