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Modified interferon-beta (IFN-beta) polypeptides

  • US 20080038224A1
  • Filed: 03/27/2007
  • Published: 02/14/2008
  • Est. Priority Date: 03/28/2006
  • Status: Abandoned Application
First Claim
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1. A modified IFN-β

  • polypeptide, comprising;

    an amino acid modification in an unmodified IFN-β

    polypeptide at positions corresponding to amino acid position L5 or L6 in the mature IFN-β

    polypeptide set forth in SEQ ID NO;

    1, wherein a modification is a replacement (substitution), addition, deletion, or a combination thereof, of amino acid residues; and

    one or more additional amino acid modifications at another position.

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