Methods and kits for early stage caries detection
First Claim
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1. A method for detecting an early stage dental caries in a subject, the method comprising:
- contacting a caries lesion which is at an early stage, selectively binding an optically detectable probe to the caries; and
detecting the caries having bound probe using an optical device.
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Abstract
Methods and kits are provided for identifying very early stage carious lesions using a detectable probe that binds to the lesion.
63 Citations
52 Claims
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1. A method for detecting an early stage dental caries in a subject, the method comprising:
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contacting a caries lesion which is at an early stage, selectively binding an optically detectable probe to the caries; and
detecting the caries having bound probe using an optical device. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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- 36. A kit for detecting early stage dental caries in a subject, the kit comprising a detectable probe that binds to the caries, the kit further comprising a container, and a positive control tooth sample having an early stage lesion.
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37. A kit for detecting early stage dental caries in a subject, the kit comprising at least one probe selected from the group of:
- colloidal gold;
a fluorescent probe; and
a bioluminescent;
wherein the probe binds selectively to the caries, the kit further comprising a container, and a positive control tooth sample having an early stage lesion.
- colloidal gold;
- 41. A kit for detecting early stage dental caries in a subject, the kit comprising a detectable probe, an optical device, and a container.
Specification