IL-23p40 Specific Immunoglobulin Derived Proteins, Compositions, Epitopes, Methods and Uses

• US 20080038831A1
• Filed: 06/26/2007
• Published: 02/14/2008
• Est. Priority Date: 09/24/2004
• Status: Active Grant

• Current Assignee: Jacqueline Benson, Jeffrey Luo, Mark Cunningham
• Original Assignee: Jacqueline Benson, Jeffrey Luo, Mark Cunningham
• Inventors: Luo, Jeffrey, Cunningham, Mark, Benson, Jacqueline
• Granted Patent: US 7,807,471 B2
• Time in Patent Office: Days
• US Class Current: 436/86
• CPC Class Codes: C07K 16/244 Interleukins [IL]
• CPC Class Codes: C07K 2317/34 Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
• CPC Class Codes: G01N 33/6869 Interleukin

Abstract

An anti-IL-23 specific human Ig derived protein, isolated nucleic acids that encode at least one anti-IL-23 Ig derived protein, vectors, host cells, transgenic animals or plants, and methods of making and using thereof are useful as therapeutic and diagnostic compositions, methods and devices. The anti-IL-23 Ig derived protein preferably binds to one or more of the Seg 1, Seg 2, and Seg 3 epitopes of the p40 subunit of IL-23.

Claims

1. A method of screening for or selecting an anti-IL-23 Ig derived protein, comprising using a variant murine p40 subunit of IL-23, wherein the variant murine p40 subunit of IL-23 is replaced by all or a portion of at least one member selected from the group consisting of Seg 1 of human IL-23p40, Seg 2 of human IL-23p40, and Seg 3 of human IL-23p40.

2. The method of claim 1, wherein the amino acid sequence of the Murineseg 2 of murine IL-23p40 is replaced by Seg 2 of human IL-23p40.

3. The method of claim 1, wherein the step of using a variant murine p40 subunit of IL-23 comprises panning a library with the variant murine p40 subunit of IL-23 or administering to an animal capable of producing Ig derived proteins the variant murine p40 subunit of IL-23.

4. The method of claim 3, further comprising recovering an anti-IL-23 Ig derived protein.