Implantable Mri compatible Stimulation Leads And Antennas And Related Systems And Methods
First Claim
Patent Images
1. An in vivo medical stimulation probe, comprising:
- an elongate lead having at least one stimulation electrode disposed on a distal portion thereof and an axially extending shielding layer; and
a plurality of axially spaced apart RF chokes disposed on and/or in the shielding layer in advance of the at least one electrode to inhibit induced RF current from forming and/or traveling along the shielding layer.
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Abstract
In vivo medical stimulation probes include an elongate lead having at least one stimulation electrode disposed on a distal portion thereof. The probes may include a plurality of axially spaced apart RF chokes disposed on and/or in an axially extending shielding layer of the lead in advance of the at least one electrode to inhibit induced RF current from forming and/or traveling along the shielding layer.
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Citations
72 Claims
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1. An in vivo medical stimulation probe, comprising:
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an elongate lead having at least one stimulation electrode disposed on a distal portion thereof and an axially extending shielding layer; and
a plurality of axially spaced apart RF chokes disposed on and/or in the shielding layer in advance of the at least one electrode to inhibit induced RF current from forming and/or traveling along the shielding layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A chronically implantable deep brain stimulation and MRI imaging probe system, comprising:
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an internal MRI-compatible elongate lead comprising an MRI antenna having axially extending, radially spaced apart first and second shielding layers and at least one core conductor, for internally receiving local in vivo MRI signals;
at least one electrode held on a distal portion of the lead that, in operation, is configured to generate a stimulation pulse to deep brain tissue;
a stimulation circuit in communication with the at least one electrode;
a MRI signal receiver circuit in communication with the MRI antenna;
a splitter circuit in communication with the stimulation and receiver circuits for electrically connecting either the MRI receive or stimulation circuit; and
means for inhibiting RF induced current on the second shield layer of the lead. - View Dependent Claims (17, 18, 19, 20, 21, 22)
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23. An MRI compatible deep brain stimulation and MRI signal acquiring probe system comprising:
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a flexible elongate probe body having opposing proximal and distal portions, the probe body comprising a plurality of electrodes disposed on the distal portion;
a plurality of axially extending conductors disposed in a core of the probe body, a respective one of the conductors associated with each electrode;
an axially extending inner shield surrounding the plurality of conductors for at least a major portion of the length of the conductors;
an axially extending second shield radially spaced apart above the inner shield;
an axially extending first insulating/dielectric layer disposed intermediate of the inner and second shields;
an MRI antenna member disposed at least partially on and/or in the probe body to be able to collect MRI signals at the distal portion thereof;
an RF transmit decoupling circuit in communication with the MRI antenna member; and
at least one connector attached to the proximal portion of the probe body, configured to hold a conductor transmission line for each of the electrodes. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A medical kit, comprising:
an elongate sterilized biocompatible and MRI-compatible lead having opposing distal and proximal portions, the lead comprising an MRI antenna, a plurality of stimulation electrodes on the distal portion, and a plurality of axially spaced apart RF chokes disposed in a shielding layer of the lead, the lead configured to have selective operative first and second electrical transmission paths associated with at least first and second operational modes, the first transmission path connecting the MRI antenna with an MRI scanner and decoupling the electrodes during MRI operation and the second transmission path connecting the electrodes with a stimulation, ablation or recording source during electrical stimulation, ablation or recording, respectively. - View Dependent Claims (42, 43, 44, 45)
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46. A method of placing and operating a deep brain stimulation probe, comprising:
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inserting a flexible elongate lead comprising an MRI antenna and at least one stimulation electrode on a distal portion thereof into a brain of a subject;
connecting the lead to an MRI scanner interface in communication with a splitter circuit having a first electric transmission path for MRI operation and a second electric transmission path for stimulation operation;
obtaining MRI signals associated with local neural tissue proximate the MRI antenna from the MRI antenna using the first transmission path;
placing the electrode on the lead at a desired location in the brain based on the obtaining step;
thenstimulating neural tissue with the electrode using the second transmission path; and
configuring the lead to inhibit the formation and/or transmission of RF induced current, wherein the stimulating and obtaining steps are carried out using the same lead. - View Dependent Claims (47, 48, 49, 50, 51, 52, 53, 54, 55, 56)
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57. A computer program product for operating a multi-purpose MRI compatible stimulation probe and MRI antenna, the computer program product comprising:
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a computer readable storage medium having computer readable program code embodied in said medium, said computer-readable program code comprising;
computer readable program code that controllably engages one of a plurality of operation modes including a first or second operational mode for an MRI-compatible stimulation probe with at least one electrode and an MRI antenna, the first operational mode having a first transmission path connecting the MRI antenna with an MRI scanner and decoupling the electrodes during MRI operation and the second operational mode having a second transmission path connecting the electrodes with a stimulation or recording source during electrical stimulation or recording. - View Dependent Claims (58, 59, 60)
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61. An MRI compatible therapeutic stimulation probe comprising:
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an elongate flexible probe body having an axially extending internal cavity disposed therein;
at least one electrode held by a distal portion of the probe body; and
at least one axially extending conductor configured to slidably extend into the cavity of the probe body, the at least one conductor having increased rigidity relative to the probe body, wherein, during positioning in a body, the at least one conductor cooperates with the probe body and defines an in vivo MRI antenna used to obtain MRI signals for MRI positional guidance, and wherein, after placement, the at least one conductor can be removed from the probe body, leaving the probe body and electrode in position in the body. - View Dependent Claims (62, 63, 64, 65)
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66. An MRI antenna and stimulation probe system, comprising:
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an MRI compatible cannula having an axially extending bore; and
an elongate flexible stimulation and internal MRI signal acquisition probe having at least one electrode held by a distal portion of the probe;
wherein the stimulation and antenna probe are configured to slidably extend through the cannula bore and wherein, in operation, the cannula and antenna probe cooperate to define components of at least one deep brain MRI signal receive antenna. - View Dependent Claims (67, 68, 69, 70, 71, 72)
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Specification