Implantable devices with photocatalytic surfaces for treating hydrocephalus

• US 20080039768A1
• Filed: 01/04/2007
• Published: 02/14/2008
• Est. Priority Date: 08/10/2006
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Francis, Richard W.
• Application Number:
  US11/649,288
• Publication Number:
  US 20080039768A1
• Time in Patent Office: Days
• US Class Current: 604/8
• CPC Class Codes: A61M 2039/167 with energizing means, e.g. light, vibration, electricity
• CPC Class Codes: A61M 2205/0233 Conductive materials, e.g. antistatic coatings for spark prevention
• CPC Class Codes: A61M 27/006 Cerebrospinal drainage; Accessories therefor, e.g. valves
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 5/0601 Apparatus for use inside the body
• CPC Class Codes: A61N 5/062 Photodynamic therapy, i.e. excitation of an agent

Abstract

A medical device comprising a least one photocatalytic layer or superhydrophilic layer. In some embodiments, the medical device comprises a waveguide. In some embodiments, the medical device comprises an electrode comprising an optically transparent conductive oxide. In some embodiments, the medical device comprises a electroluminescent layer. In some embodiments, the medical device comprises a photovoltaic cell. According to some embodiments, the medical device comprises a doped semiconductor oxide. In some embodiments the medical device is a hydrocephalus shunt. A method for increasing the energy efficiency of a photocatalytic surface comprises electrically biasing a transparent conductive oxide layer. A method for illuminating a complex three-dimensional surface comprises illuminating a photocatalytic layer with electromagnetic radiation from an electroluminescent layer. A method for removing or preventing the formation of organic matter on a sensor window.

Claims

1. A method of treating hydrocephalus, comprising the steps of:

a) inserting into a human cranium a hydrocephalus shunt having a component having a surface, and b) producing reactive oxygen species on the component surface.

2. The method of claim 1 wherein the component surface comprises a photocatalytic material.

3. The method of claim 2 wherein the component surface comprises a photocatalytic layer.

4. The method of claim 2 wherein the step of producing reactive oxygen species comprises illuminating the photocatalytic surface with light from a fiber optic cable.

5. The method of claim 1 wherein the component surface is a proximal catheter surface.

6. The method of claim 1 wherein the component surface is a distal catheter surface.

7. The method of claim 1 wherein the component surface is a valve component surface

8. The method of claim 1 wherein the ROS are produced in an amount sufficient to oxidize organic mater present within a lumen of the shunt.

9. The method of claim 1 wherein the component surface comprises a photosensitizer coating.

10. A hydrocephalus shunt having a catheter comprising a photocatalytic material.

11. The shunt of claim 10 wherein the photocatalytic material comprises a semiconductor oxide.

12. The shunt of claim 11 wherein the semiconductor oxide comprises a titanium dioxide selected from the group consisting of anatase and rutile, and mixtures thereof.

13. The shunt of claim 10 wherein the photocatalytic material comprises a dopant.

14. The shunt of claim 10 wherein the photocatalytic material is present upon an inside surface of the catheter.

15. The shunt of claim 10 wherein the photocatalytic material is present upon an outside surface of the catheter.

16. The shunt of claim 10 wherein the catheter comprises an inside surface, an outside surface and an inlet hole providing fluid connection therebetween, and wherein the photocatalytic material is present upon a surface of the inlet hole.

17. The shunt of claim 10 wherein the catheter is made of a composite material comprising the photocatalytic material.

18. The shunt of claim 17 wherein the composite comprises poly(dimethylsiloxane).

19. The shunt of claim 18 wherein the photocatalytic material comprises titania.

20. The shunt of claim 10 wherein the catheter comprises poly(dimethylsiloxane).

21. A hydrocephalus shunt having a catheter comprising a wave guide.

22. The shunt of claim 21 wherein the wave guide comprises at least one fiber.

23. The shunt of claim 22 wherein the fiber comprises glass.

24. The shunt of claim 22 wherein the fiber comprises a polymer.

25. The shunt of claim 24 wherein the polymer is selected from the group consisting of silicones, urethanes, acrylics and polycarbonates.

26. The shunt of claim 21 wherein the catheter comprises a first lumen adapted for transported CSF, and a second lumen adapted for carrying the wave guide.

27. The shunt of claim 26 wherein the second lumen has a fiber optic cable contained therein.

28. The shunt of claim 24 further comprising a light port adapted for transmitting light to the wave guide.

29. The shunt of claim 24 wherein the wave guide has a transmissivity to 320-700 nm (UV) light of at least 90%.

30. The shunt of claim 21 wherein the catheter is a composite and the wave guide is present as a component of the composite.

31. The shunt of claim 30 wherein the wave guide component of the composite comprises a glass oxide.

32. The shunt of claim 30 wherein the wave guide component of the composite comprises a polymer.

33. The shunt of claim 21 further comprising an LED adapted for transmitting light to the wave guide.

34. A hydrocephalus shunt comprising a light source.

35. The shunt of claim 34 wherein the light source is an LED.

36. The shunt of claim 34 wherein the light source is adapted to transmit UV light.

37. The shunt of claim 34 wherein the light source comprises AlGaN.

38. The shunt of claim 34 wherein the light source is battery operated.

39. The shunt of claim 34 further comprising an antenna, wherein the light source is powered by the antenna.

40. The shunt of claim 34 further comprising a catheter, and wherein the light source is adapted to transmit light to the catheter.

41. The shunt of claim 40 wherein the catheter further comprises a wave guide, and wherein the light source is adapted to transmit light to the wave guide.

42. The shunt of claim 34 further comprising a proximal catheter and a distal catheter, and wherein the light source is located between the catheters.

43. The shunt of claim 42 further comprising a housing comprising a valve, wherein the housing is located between the catheters.

44. The shunt of claim 43 wherein the housing contains the light source.

45. The shunt of claim 43 wherein the light source is outside the housing.

46. The shunt of claim 45 wherein the light source is located proximal to the housing.

47. A method of manufacturing a hydrocephalus shunt having a valve component and a catheter component having a photocatalytic material, comprising the steps of:

a) attaching the catheter component to the valve component.

48. The method of claim 47 wherein the catheter comprises a base material having a surface, and the photocatalytic material is coated upon the surface.

49. A hydrocephalus shunt comprising a light port.

50. The shunt of claim 49 further comprising a proximal catheter and a distal catheter, and wherein the light port is located between the catheters.

51. The shunt of claim 50 further comprising a housing comprising a valve, wherein the housing is located between the catheters.

52. The shunt of claim 51 wherein the housing contains the light port.

53. The shunt of claim 51 wherein the light port is outside the housing.

54. The shunt of claim 51 wherein the light port is located proximal to the housing.