Devices and methods for atrial appendage exclusion

• US 20080039879A1
• Filed: 08/09/2006
• Published: 02/14/2008
• Est. Priority Date: 08/09/2006
• Status: Abandoned Application

• Current Assignee: Maquet Cardiovascular LLC (Getinge AB)
• Original Assignee: Maquet Cardiovascular LLC (Getinge AB)
• Inventors: Willis, Geoffrey H., Shroff, Ketan, Chin, Albert K., Davis, John W., Agarwal, Amit, Uemura, Shuji, Callas, Peter L., Gresl, Charles, Cantu, Alfredo R.
• Application Number:
  US11/502,249
• Publication Number:
  US 20080039879A1
• Time in Patent Office: Days
• US Class Current: 606/157
• CPC Class Codes: A61B 17/064 Surgical staples, i.e. penetrating the tissue
• CPC Class Codes: A61B 17/0643 with separate closing member, e.g. for interlocking with staple
• CPC Class Codes: A61B 17/068 Surgical staplers , e.g. containing multiple staples or clampsstaplers containing only one staple A61B17/10; magazines or containers for staples A61B17/105; for performing anastomosis A61B17/115; staplers in general B25C5/00
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 17/1227 Spring clips
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/0647 having one single leg, e.g. tacks
• CPC Class Codes: A61B 2017/0649 Coils or spirals
• CPC Class Codes: A61B 2017/1225 for clipping and cutting in a single operation

Abstract

Devices, tools and methods for occluding fluid flow between two walls of tissue in a patient. Two walls of tissue are compressed together with sufficient compressive force to prevent fluid flow between the two walls, while ensuring that the compressive force is not so great as to cause tissue necrosis. The devices, tools and methods may be carried out using minimally invasive surgical techniques, such as in reduced-access surgical sites. Devices, tools and methods are provided for occluding an atrial appendix.

Claims

1. A device for occluding fluid flow between two walls of tissue in a patient, said device comprising:

a base configured to apply compressive force against a first of the two walls; and

at least one opposing member configured to apply compressive force against a second of the two walls upon installing the device, wherein, when installed, said base and said at least one opposing member compress the two walls therebetween, and a gap of predetermined dimension is established between said base and said at least one opposing member to sufficiently compress the two walls to occlude fluid flow therebetween, while preventing an establishment of a compression force that meets or exceeds a compression force to cause tissue necrosis.

2. The device of claim 1, wherein the two wall of tissue are opposing walls at the base of an atrial appendage.

3. The device of claim 1, comprising a clip, wherein said base comprises a first jaw of the clip and said at least one opposing member comprises a second jaw of the clip, said first and second jaws being joined at first ends thereof by a hinge, and second ends of said first and second jaws comprising a locking mechanism, wherein said first and second jaws are pivotable away from one another to an open position, and are pivotable towards one another to a closed position wherein said second ends are locked together via said locking mechanism, and wherein said gap of predetermined dimension is established in said closed position.

4. The device of claim 3, wherein said first and second jaws each have a length sufficient to exceed the length of a base portion of a left atrial appendage of a human heart.

5. The device of claim 3, further comprising compressible material lining inside surfaces of said first and second jaws, wherein said inside surface of said first jaw faces and opposes said inside surface of said second jaw.

6. The device of claim 3, further comprising a tool interface formed on each of said first and second jaws.

7. The device of claim 6, wherein said tool interfaces comprise loops extending from said first and second jaws.

8. The device of claim 3, wherein said first and second jaws extend longitudinally along a longitudinal axis, and wherein at least one pair of sides of said first and second jaws are curved relative to said longitudinal axis.

9. The device of claim 3, wherein a second of said pairs of sides of said first and second jaws are substantially straight and parallel to said longitudinal axis.

10. The device of claim 1, comprising a clip, wherein said base comprises a first jaw of the clip and said at least one opposing member comprises a second jaw of the clip, said first and second jaws being joinable at first ends thereof comprising a first locking mechanism, and second ends of said first and second jaws comprising a second locking mechanism, wherein said first and second jaws are movable away from one another in an open position, and are connectable to one another to assume a closed position wherein said first ends are locked together via said first locking mechanism and said second ends are locked together via said second locking mechanism, and wherein said gap of predetermined dimension is established in said closed position.

11. The device of claim 3, wherein at least one of said jaws includes a rib extending longitudinally therealong to reinforce said jaw against bending.

12. The device of claim 3, wherein at least one of said jaws is dished to provide additional rigidity, wherein edges of said jaw function as longitudinal strengthening ribs.

13. The device of claim 1, wherein at least one of said base and said at least one opposing member has at least one opening therein, wherein upon compressing said base and said at least one opposing member against the tissue walls, tissue protrudes through said at least one opening.

14. The device of claim 1, comprising a malleable clip, wherein said at least one opposing member comprises at least one tine extending from said base and having a distal tissue piercing end.

15. The device of claim 14, further comprising a pair of soft pads adapted to distribute compressive loads, wherein a first of said pair is positioned between said base and the first of the two walls, and a second of said pair is positioned between said at least one opposing member and the second of the two walls.

16. The device of claim 14, wherein said at least one tine extends from said base at an acute angle, wherein said device is configured to be slid laterally with respect to one of the tissue walls whereupon said at least one tine pierces the wall and is deformed toward a perpendicular orientation with respect to said base.

17. The device of claim 1, wherein said base comprises a first plate with a plurality of barbed connecting members extending therefrom, and said at least one opposing member comprises a second plate connectable to said first plate by insertion of said barbed connecting members therethrough, and wherein said gap of predetermined dimension is defined by a distance from said first plate to a proximal end of one of said barbs and a thickness of said second plate.

18. The device of claim 1, wherein said base comprises a first plate having first and second end portions with first and second connectors extending from said first and second end portions, and said at least one opposing member comprises a second plate connectable to said first plate by connection of said first and second connectors to first and second end portions of said second plate, and wherein said gap of predetermined dimension is defined by a length of said connectors and a thickness of said second plate.

19. The device of claim 1, further comprising an insertable body configured to be inserted between the two walls, wherein said base and said at least one opposing member each comprise connectors configured to connect to said insertable body and compress the first and second tissue walls against said insertable body, respectively.

20. The device of claim 17, further comprising a living hinge interconnecting said first and second plates.

21. The device of claim 17, wherein at least one of said barbed interconnecting members comprises a plurality of barbs, and wherein said gap of predetermined dimension is selectable from a plurality of predetermined dimensions dependent upon locations of said plurality of barbs.

22. The device of claim 1, wherein said base comprises a first clamping arm and said at least one opposing member comprises a second clamping arm, wherein said first and second clamping arms are interconnected by torsion arms.

23. The device of claim 1, wherein said base comprises a first clamping arm and said at least one opposing member comprises a second clamping arm, wherein said first and second clamping arms are interconnected by a torsion bar that is twistable about an axis of rotation when moving said first and second clamping arms apart from one another, said first and second clamping arms being rigid about said axis of rotation.

24. The device of claim 1, wherein a flexible stem extends from said base, said base being configured to be rotated to align with said flexible stem for insertion into a tubular delivery device.

25. The device of claim 1, wherein said base comprises a first plate and said at least one opposing member comprises a second plate cooperable with said first plate to compress the first and second walls together, said first and second plated being operable by flexible lines connected to one of said first and second plates and threaded through the other of said first and second plates, wherein flexible lines may be drawn upon to drive said first and second plates toward one another.

26. The device of claim 25, wherein at least one of said first and second plates comprises side walls extending therefrom, said side wall defining said predetermined dimension.

27. The device of claim 1, wherein said at least one opposing member comprises malleable tines extending from said base member, said device further comprising a tensioning member connected to said malleable tines and slidably passing through said base, wherein when tension is applied to said tensioning member and said base is held stationary, said malleable tines are deformed to compress toward said base.

28. The device of claim 1, wherein said base and said at least one opposing member comprise a pair of rigid, opposing elongated members, said elongated members being connected at one end by an elastic joint.

29. The device of claim 28, wherein said elongated members have an undulating shape to enhance friction against the tissue walls.

30. The device of claim 28, further comprising tabs extending from sides of said elongated members and adapted to be received in channels of a delivery tool.

31. The device of claim 1, wherein said base and said at least one opposing member comprise a pair of rigid, opposing elongated members, said elongated members being connected at one end by a malleable joint, said malleable joint being deformable to compress said elongated members against the tissue walls.

32. The device of claim 31, wherein said malleable joint is formed to have an acute angle bend and an obtuse angle bend.

33. The device of claim 1, wherein said base and said at least one opposing member comprise a pair of opposing elongated members, said elongated members being connected at one end by an elastically deformable joint and having free ends opposite of ends connected by said elastically deformable joint, said device further comprising a flexible line fixed to said free end of one of said elongated members and threadable through an opening in said free end of the other of said elongated members.

34. The device of claim 33, wherein said elongated members and said joint are formed of a shape memory material.

35. The device of claim 33, further comprising tool engagement features formed in said elongated members, said tool engagement features adapted to be engaged by a spreading tool.

36. The device of claim 35, wherein said tool engagement features comprise slots.

37. A device for occluding fluid flow between two walls of tissue in a patient, said device comprising:

a springform clip comprising at least three arms of substantially equal length, formed by bending an elongated member of spring metal, said arms being elastically deformable to insert the tissue walls therebetween, and having sufficient length to traverse an entire width of the tissue walls defining a passageway through which fluid flow occurs, wherein, upon releasing said arms from a deformed, open configuration, said arms elastically spring back toward an undeformed configuration to compress the tissue walls with sufficient force to occlude fluid flow therebetween, while preventing an establishment of a compression force that meets or exceeds a compression force to cause tissue necrosis.

38. The device of claim 37, further comprising traction features on at least one of said arms, to enhance friction between said device and the tissue walls compressed thereby.

39. A device for occluding fluid flow between two walls of tissue in a patient and a tool for installing said device, comprising:

a base configured to apply compressive force against a first of the two walls;

at least one opposing member configured to apply compressive force against a second of the two walls upon installing the device, wherein, when installed, said base and said at least one opposing member compress the two walls therebetween, and a gap of predetermined dimension is established between said base and said at least one opposing member to sufficiently compress the two walls to occlude fluid flow therebetween, while preventing an establishment of a compression force that meets or exceeds a compression force to cause tissue necrosis; and

a tool configured to interface with at least one of said base and at least one opposing member, to drive said device in compression against the tissue walls.

40. The device and tool of claim 39, further comprising a tool interface formed on said base and at least one said opposing member, wherein said tool comprises first and second arms moveable toward and away from one another, said first and second arms having control features configured to engage said tool interfaces form movement of said base and at least one said opposing member toward and away from one another.

41. The device and tool of claim 40, wherein said tool interfaces comprise loops, and said control features comprise tips of said arms.

42. The device and tool of claim 41, wherein said device comprises a clip, wherein said base comprises a first jaw of the clip and said at least one opposing member comprises a second jaw of the clip, said first and second jaws being joined at first ends thereof by a hinge, and second ends of said first and second jaws comprising a locking mechanism, wherein said first and second jaws are pivotable away from one another to an open position, and are pivotable towards one another to a closed position wherein said second ends are locked together via said locking mechanism, and wherein a gap of predetermined dimension is established in said closed position.

43. The device and tool of claim 42, wherein said first and second jaws each have a length sufficient to exceed the length of a base portion of a left atrial appendage of a human heart.

44. The device and tool of claim 41, wherein said tips are angled with respect to a remainder of said arms from which they extend.

45. The device and tool of claim 39, wherein said at least one opposing member comprises at least one malleable tine, and wherein said tool includes a pair of opposable jaws that are movable toward and away from one another, said tool further including mounting means on one of said jaws for mounting said base on said jaw, and wherein the other of said pair of jaws comprises an anvil against which said at least one malleable tine is deformed upon actuation of said tool to move said jaws toward one another to drive said at least one tine against said anvil.

46. The device and tool of claim 45, wherein said tool further comprises a stop configured to limit movement of said jaws towards one another to positions wherein a gap of predefined dimension is established between said jaws.

47. The device and tool of claim 39, wherein said device further comprises a flexible stem extending from said base, and said tool includes a tube, said stem being bendable for rotation of said base to orient said base to be inserted into said tube, and wherein said flexible stem has sufficient length to extend proximally from a proximal end of said tube when said base is outside of said tube and adjacent to said distal end of said tube, while said flexible member extends through said tube.

48. The device and tool of claim 47, wherein said at least one opposing member comprises a collar, wherein said flexible stem is threaded through said collar.

49. The device and tool of claim 47, comprising a slot in at least a distal portion of said tube.

50. The device and tool of claim 47, further comprising an elongated, rigid driver configured to pass through said tube and contact said base, wherein application of force through said driver to said base facilitates ejection of said base from said tube.

51. The device and tool of claim 48, further comprising a driver proximal of said collar and through which said flexible stem is threaded, said driver being slidable distally along said threaded member to move said collar toward said base.

52. The device and tool of claim 48, further comprising ratchet features on a distal portion of said flexible stem, said ratchet features configured to prevent sliding of said collar proximally along said flexible stem.

53. The device and tool of claim 39, wherein said device comprises a malleable clip, wherein said at least one opposing member comprises at least one tine extending from said base and having a distal tissue piercing end, and wherein said tool comprises a tool base against which said base of said device is positioned during installation of said device, and an anvil member having an elongated member slidably extending through said tool base and device, and an enlarged member, wherein, upon drawing said elongated member through said tool base, said enlarged member is driven against said at least one tine to deform said at least one tine into compression against one of the tissue walls.

54. The device and tool of claim 53, wherein said enlarged member of said anvil member comprises a sharpened distal end to facilitate piercing the tissue walls.

55. The device and tool of claim 39, wherein said base and said at least one opposing member comprise a pair of rigid, opposing elongated members, said elongated members being connected at one end by an elastic joint, and wherein said tool comprises opposing jaws mounted for articulation with respect to one another wherein said jaws are drivable together to compress the tissue walls therebetween in preparation for a ligation, said tool comprising a channel passing therethrough, said channel being dimensioned to slide said device therethrough for installation of said device over the compressed tissue walls.

56. The device and tool of claim 55, further comprising tabs extending from sides of said elongated members, and wherein said tool further comprises secondary channels in which said tabs are slidable, wherein said secondary channels guide said elongated members apart, into an open configuration as said device is being slid over the tissue walls, and then into a closed, clamping configuration at a final position for installation of said device.

57. The device and tool of claim 39, wherein said base and said at least one opposing member comprise a pair of rigid, opposing elongated members, said elongated members being connected at one end by a malleable joint, said malleable joint being deformable to compress said elongated members against the tissue walls, and wherein said tool comprises opposing jaws mounted for articulation with respect to one another wherein said jaws are drivable together to compress the tissue walls therebetween in preparation for a ligation, said tool comprising a channel passing therethrough, said channel being dimensioned to slide said device therethrough for installation of said device over the compressed tissue walls.

58. The device and tool of claim 57, further comprising an elongated pusher adapted to drive said device through said channel and to deform said malleable joint to compress said elongated members against the tissue walls.

59. The device and tool of claim 58, wherein said malleable joint, prior to deformation, comprises an acute angle bend and an obtuse angle bend, and wherein, compression of said elongated members by said pusher deforms said acute bend to form a smaller acute angle and increases the obtuse angle of the obtuse bend.

60. The device and tool of claim 39, further comprising a suction applicator, comprising an elongated tool body configured to be passed through a small thoracotomy, said suction applicator further comprising a tissue contacting member at a distal end thereof, said tissue contacting member being connectable to a suction source via a suction line extending the length of said suction applicator.

61. An assembly for performing an occlusion of fluid flow between two walls of tissue in a patient, said assembly comprising:

a device configured to maintain the two walls under sufficient compression to prevent fluid flow therebetween; and

a tool configured to guide installation of said device into a final configuration where said device maintains the two walls under said sufficient compression.

62. The assembly of claim 61, wherein said device comprises an elongated spiral shaped device, wherein and inside diameter of coils of said spiral shaped device is dimensioned to maintain the two walls under said sufficient compression, and wherein said tool comprises opposing jaws mounted for articulation with respect to one another wherein said jaws are drivable together to compress the tissue walls therebetween in preparation for a ligation, said tool comprising a channel passing therethrough, and pockets or threads to guide threading of said device therealong as said device is threaded through the compressed walls.

63. The assembly of claim 62, further comprising a rigid elongated driver dimensioned to be slidably received in said channel, said driver comprising a slot along a length thereof, a proximal end of said device extending inwardly of said inner diameter to engage with said slot.

64. The assembly of claim 61, wherein said device comprises a substantially straight, elongated needle having a sharpened distal end, and wherein said tool comprises opposing jaws mounted for articulation with respect to one another wherein said jaws have undulating opposing surfaces and are drivable together to compress the tissue walls therebetween in an undulating configuration, under said sufficient compression, said sufficient compression being less than an amount of compression to cause necrosis of the walls, in preparation for a ligation, said tool comprising a channel passing therethrough, wherein, upon passing said device through said channel with said jaws compressing the tissue walls, said device skewers the undulations of the tissue walls.

65. An assembly for performing an occlusion of fluid flow between two walls of tissue in a patient, said assembly comprising:

a multi-lumen endoscopic tool including an endoscope positionable in a lumen of said multi-lumen tool;

a steerable suction tool positionable in another lumen of said multi-lumen tool such that a distal contact surface extends distally of a distal end of the multi-lumen tool; and

a snare device insertable through another lumen of said multi-lumen tool, such that a snare at a distal end of said snare tool extends distally of said distal end of the multi-lumen tool.

66. A tissue wall coating device for minimizing bleeding caused by an incision or puncture of the tissue wall, said device comprising:

a main body in the shape of an elastomeric sack being closed at one end and having an opening at a base portion end; and

a ligature extending around said base portion end and configured to constrict said opening at said base portion end.

67. A method of performing an occlusion of fluid flow between two walls of tissue in a patient, said method comprising:

compressing the two walls together under compression force sufficient to prevent fluid flow between the two walls, but not so great to cause tissue necrosis; and

maintaining said compression force by installation of a device configured to maintain the walls between at least two contact surfaces separated from one another by a gap of predetermined dimension.

68. The method of claim 67, wherein said occlusion is performed on two walls of an atrial appendage.

69. The method of claim 67, wherein said occlusion is performed in a reduced-access surgical site.

70. The method of claim 67, wherein said device comprises a clip having opposing jaws, and wherein said compressing and maintaining said compression force comprises extending said clip over an entire width of the tissue walls, moving said opposing jaws toward one another to establish said compression force and locking relative positions of said jaws in compression against the two walls, wherein a gap of predetermined dimension is established and maintained between said jaws.

71. The method of claim 70, further comprising releasing said locking of the relative positions, repositioning said jaws relative to the tissue walls and locking relative positions of said jaws again to establish and maintain said gap.

72. The method of claim 67, further comprising laterally sliding, relative to one of the tissue walls, a portion of the device comprising a plate having tines extending therefrom at an acute angle, wherein said tines pierce the tissue wall;

continuing said lateral sliding to increase the angle of said tines with respect to said plate toward perpendicular;

forcing said tines and said plate toward the tissue wall to pierce both walls of tissue with said tines and cause distal end of said tines to extend from an opposite surface of the second wall of tissue;

wherein said compressing comprises deforming said tines against the opposite surface to compress the two walls between the deformed tines and said plate.

73. The method of claim 72, further comprising placing a first pad between over said tines and against said plate prior to said lateral sliding, and placing a second pad over said tines and against the opposite surface prior to said deforming said tines, wherein the tissue walls are compressed between said first and second pads.

74. The method of claim 67, wherein said device comprises opposing contact surfaces connected by connecting members having ratcheting features, said method further comprising varying a distance between said opposing contact surfaces in a location of at least one of said connecting members, wherein at least two different gaps of different predetermined dimensions are maintained at different locations along said contact surfaces.

75. The method of claim 67, wherein the tissue walls are the tissue walls along the base of an atrial appendage, said method further comprising:

folding over the atrial appendage after occluding flow between the tissue walls at the base; and

attaching the folded over tissue of the atrial appendage to the adjacent atrium or other adjacent tissue.

76. The method of claim 67, wherein the tissue walls are the tissue walls along the base of an atrial appendage, said method further comprising:

twisting and folding over the atrial appendage after occluding flow between the tissue walls at the base; and

attaching the twisted, folded over tissue of the atrial appendage to the adjacent atrium or other adjacent tissue.

77. The method of claim 67, further comprising piercing through the two walls of tissue with a tubular member having a sharpened distal end;

ejecting a base member connected to a flexible stem from said sharpened distal end, whereby said flexible stem extends through the two walls of tissue;

removing said tubular member from the tissue walls; and

wherein said compressing and maintaining are carried out by sliding a collar over said flexible stem and against a first of the tissue walls wherein the tissue walls are compressed between said collar and base, and fixing a position of said collar relative to said base to define said gap.

78. The method of claim 67, wherein said device comprises a pair of plates, further comprising providing an opening between said pair of plates sufficient to allow said plates to be positioned over the two tissue walls;

orienting said plates adjacent to locations on the tissue walls where the occlusion is desired;

wherein said compressing is carried out by drawing on connecting members attached to one of said plates and threaded through the other, to draw said plates together in compression; and

wherein said maintaining is effected by fixing said connecting members relative to said plate that said connecting members are threaded through.

79. The method of claim 67, wherein said compressing comprises clamping opposing jaws of a delivery tool over the two walls, wherein the delivery tool is configured to prevent complete closure of the opposing jaws together, being stopped to define a predetermined gap therebetween;

and wherein said maintaining is effected by sliding a device through a channel formed in said delivery tool, over the two tissue walls, wherein said device maintains the tissue walls between opposing members separated by said gap of predetermined dimension.

80. The method of claim 79, further comprising removing said delivery tool from the two walls of tissue.

81. The method of claim 79, further comprising crimping said device to compress the opposing members toward one another to assume locations defining said gap of predetermined dimension.

82. The method of claim 67, further comprising contacting at least one of the tissue walls with a contact member of a manipulator, at a location in the vicinity where the occlusion is to be performed, applying suction through the contact member to attaché

the contact member to the tissue wall; and

moving the tissue by moving the manipulator, to facilitate said compressing and maintaining steps.

83. The method of claim 67, wherein said device comprises a clip having opposing jaws, and wherein said compressing comprises extending said clip over an entire width of the tissue walls with said opposing jaws being held in an open, elastically deformed configuration, and releasing said opposing jaws to permit said jaws to moving toward one another to establish said compression force;

and

wherein said maintaining said compression force includes drawing a tie line against the tissue walls, between open ends of said opposing jaws.

84. The method of claim 67, wherein said compressing comprises clamping opposing jaws of a delivery tool over the two walls, wherein the delivery tool is configured to prevent complete closure of the opposing jaws together, being stopped to define a predetermined gap therebetween;

and wherein said maintaining is effected by screwing a helical device through the two walls, wherein said screwing is guided by pockets or threads formed in the opposing surfaces of said jaws.

85. The method of claim 84, further comprising removing said delivery tool from the two walls of tissue.

86. The method of claim 67, wherein said compressing comprises clamping opposing jaws of a delivery tool over the two walls, wherein the delivery tool is configured to prevent complete closure of the opposing jaws together, being stopped to define a predetermined gap therebetween;

and wherein said maintaining is effected by screwing a helical device through the two walls, wherein said screwing is guided by pockets or threads formed in the opposing surfaces of said jaws, and wherein said helical device has a removable base mounted on a distal end thereof, said removable base further comprising a flexible member attached thereto and extending proximally thereof, such that upon screwing said base through the two tissue walls, the flexible member extends through all pierced turns of the screw installation and proximally of an entry point in the tissue walls where the screwing was initiated,

withdrawing said helical member from the tissue walls, while maintaining the removable base distally of the distal most piercing; and

knotting or otherwise anchoring said flexible member in a location adjacent the entry point.

87. The method of claim 67, wherein said compressing comprises the two walls of tissue into an undulating conformation using opposing jaws, having undulating opposing surfaces, of a delivery tool, wherein the delivery tool is configured to prevent complete closure of the opposing jaws together, being stopped to define a predetermined gap therebetween;

and wherein said maintaining is effected by skewering the undulations of compressed tissue walls with a substantially straight needle.

88. The method of claim 67, wherein said compressing comprises the two walls of tissue into an undulating conformation using opposing jaws, having undulating opposing surfaces, of a delivery tool, wherein the delivery tool is configured to prevent complete closure of the opposing jaws together, being stopped to define a predetermined gap therebetween;

and wherein said maintaining is effected by skewering the undulations of compressed tissue walls with a substantially straight needle, having a removable base mounted on a distal end thereof, said removable base further comprising a flexible member attached thereto and extending proximally thereof, such that upon skewering the undulations, the flexible member extends through all pierced undulations and proximally of an entry point in the tissue walls where the skewering was initiated,

withdrawing said needle from the undulations, while maintaining the removable base distally of the distal most piercing; and

knotting or otherwise anchoring said flexible member in a location adjacent the entry point.

89. A method of performing an occlusion of fluid flow between two walls of tissue in a patient through a small opening in the patient, said method comprising:

inserting a multi-lumen endoscopic tool through the small opening in the patient, toward a location of the two walls of tissue to be occluded;

identifying the location of the two walls of tissue to be occluded by viewing through an endoscope inserted in one of the lumens of the multi-lumen tool, and maneuvering a distal end of the multi-lumen tool to a reduced-access sited containing the two walls of tissue;

snaring the tissue walls with a snare extending at the distal end of a snare tool inserted through another lumen of the multi-lumen device;

tightening the snare from a location outside of the patient;

fixing the snare in the tightened configuration to maintain compression of the two walls; and

cutting the fixed snare away from the snare device.

90. The method of claim 89, wherein the two walls are at the base of an atrial appendage.

91. The method of claim 89, further comprising applying suction, via a suction manipulator to attach to a wall of the tissue and manipulate the tissue to facilitate at lest one of said snaring, tightening, fixing and cutting.

92. A method of reducing bleeding during a surgical procedure on an atrial appendix, said method comprising:

placing an elastomeric sack over the atrial appendix to form a slightly compressive interface between said sack and the atrial appendix;

constricting a base opening of the sack by drawing on a ligature passing through the base opening, and thereby compressing the walls of tissue at the location contacted by the base opening; and

fixing said ligature relative to the base opening to maintain said constricting.

93. The method of claim 92, further comprising excising a portion of the sack and the atrial appendage at a location above said base opening.