POROUS INTRAVASCULAR EMBOLIZATION PARTICLES AND RELATED METHODS
First Claim
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1. An embolization particle comprising a substantially spherical crosslinked polymer particle comprising a porous interior having pores that extend to the surface of said particle while the surface pores have a diameter of at least about 1 micron and said particle has a diameter ranging from about 45 microns to about 1400 microns.
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Abstract
The present invention relates to porous embolization devices, methods of making and using the devices as well as methods and devices to hydrate and deliver embolization particle(s).
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19 Claims
- 1. An embolization particle comprising a substantially spherical crosslinked polymer particle comprising a porous interior having pores that extend to the surface of said particle while the surface pores have a diameter of at least about 1 micron and said particle has a diameter ranging from about 45 microns to about 1400 microns.
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2. An embolization particle comprising a crosslinked PVA polymer that defines a plurality of pores in the interior and on the surface of the particles, wherein said pores have a diameter of greater than about 1 micron and wherein the particle is substantially spherical and has a diameter of about 45 microns or more.
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9. A method of making embolization particles comprising:
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mixing a PVA polymer and a porogen to produce a PVA mixture;
adding a substance to cause crosslinking in the PVA mixture;
removing air bubbles from the PVA mixture; and
adding the mixture to a reaction medium and stirring the mixture and medium.
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14. A method of hydrating foam embolization particle(s) comprising:
exposing said mixture to reduced pressure, mixing dehydrated foam embolization particles with a hydration solution to form a mixture in a sealed device whereby entrapped gases are removed from the particles. - View Dependent Claims (15, 16, 17, 18, 19)
Specification