METHODS AND APPARATUS FOR MITRAL VALVE REPAIR

• US 20080039935A1
• Filed: 08/13/2007
• Published: 02/14/2008
• Est. Priority Date: 08/14/2006
• Status: Abandoned Application

• Current Assignee: Fidel Realyvasquez, Wally Buch
• Original Assignee: Fidel Realyvasquez, Wally Buch
• Inventors: REALYVASQUEZ, Fidel, BUCH, Wally
• Application Number:
  US11/838,111
• Publication Number:
  US 20080039935A1
• Time in Patent Office: Days
• US Class Current: 623/2.17
• CPC Class Codes: A61F 2/2445 Annuloplasty rings in direct contact with the valve annulus
• CPC Class Codes: A61F 2/2451 Inserts in the coronary sinus for correcting the valve shape
• CPC Class Codes: A61F 2/2454 Means for preventing inversion of the valve leaflets, e.g. chordae tendineae prostheses
• CPC Class Codes: A61F 2/2466 Delivery devices therefor

Abstract

Methods and apparatus for mitral valve repair are disclosed herein where the posterior mitral leaflet is supported or buttressed in a frozen or immobile position to facilitate the proper coaptation of the leaflets. An implantable apparatus may be advanced and positioned intravascularly beneath the posterior leaflet of the mitral valve. The apparatus may include one or more individual balloon members, each of which may be optionally configured with supporting integrated structures. A magnet chain catheter may be positioned within the coronary sinus and adjacent to the mitral valve to magnetically secure the apparatus in position beneath the posterior mitral leaflet. Alternatively, a split-ring device may be placed about the chordae tendineae supporting the mitral valve such that the ring slides along the chordae tendineae alternately against the mitral leaflet and towards the papillary muscles during systole and diastole.

Claims

1. A valve leaflet support system, comprising:

at least one support member sized for intravascular delivery and having a low-profile delivery configuration and an expanded deployed configuration,

wherein the at least one support member is further sized for placement against or along an inferior surface of a posterior mitral leaflet.

2. The system of claim 1 further comprising at least one attractive element having a first magnetic polarity coupled to the at least one support member.

3. The system of claim 2 further comprising an anchoring element with at least one attractive element having a second magnetic polarity opposite to the first magnetic polarity and sized for placement in a coronary sinus of a patient.

4. The system of claim 3 wherein the anchoring element comprises a magnetic chain catheter having a plurality of magnets each with the second magnetic polarity.

5. The system of claim 3 further comprising a guiding catheter over which the anchoring element is translatable.

6. The system of claim 5 further comprising a magnetic element positioned on a distal tip of the guiding catheter.

7. The system of claim 1 further comprising a guidewire along which the at least one support member is advanceable.

8. The system of claim 1 further comprising a delivery catheter along which the at least one support member is advanceable.

9. The system of claim 8 further comprising a magnetic element positioned on a distal tip of the delivery catheter.

10. The system of claim 8 further comprising a guidewire along which the delivery catheter is advanceable.

11. The system of claim 10 further comprising an inflatable element disposed on a distal tip of the guidewire.

12. The system of claim 1 wherein the at least one support member is comprised of a single expandable balloon having a length sized for placement against or along the inferior surface of the posterior mitral leaflet.

13. The system of claim 12 further comprising an expandable scaffold or stent integrated within or upon a membrane of the expandable balloon.

14. The system of claim 1 wherein the at least one support member comprises at least three expandable balloons aligned in series.

15. The system of claim 14 further comprising an inflation shaft interconnecting the at least three expandable balloons, the inflation shaft defining a corresponding inflation opening therealong in communication with each expandable balloon.

16. The system of claim 15 further comprising a wall occluding shaft which is slidably movable within the inflation shaft, the wall occluding shaft defining at least one opening therealong for alignment with at least one inflation opening.

17. The system of claim 16 further comprising an infusion catheter rotatably movable via a helical track within the wall occluding shaft, the infusion catheter in fluid communication with a fluid reservoir.

18. The system of claim 15 wherein the inflation shaft defines at least three inflation lumens, each lumen being in fluid communication with a respective expandable balloon.

19. The system of claim 14 wherein the expandable balloons comprise an un-symmetric shape.

20. The system of claim 19 wherein the expandable balloons each define a flattened surface and a curved or arcuate surface.

21. The system of claim 14 wherein the expandable balloons comprise a spherical shape.

22. The system of claim 1 further comprising an expandable stent in the at least one support member configured to provide structural support to maintain the support member in an expanded configuration.

23. The system of claim 1 further comprising a coupling lumen positioned along a proximal end of the at least one support member, the coupling lumen having an expandable coupling mechanism positioned therein.

24. The system of claim 23 wherein the expandable coupling mechanism comprises a stent or crimp.

25. The system of claim 23 further comprising an outer catheter coupled to the at least one support member via the coupling mechanism within the coupling lumen.

26. The system of claim 25 further comprising an expandable release mechanism extending distally from the outer catheter within the coupling mechanism, wherein expansion of the release mechanism de-couples the coupling mechanism from the outer catheter.

27. A method of supporting a posterior mitral leaflet, comprising:

intravascularly advancing a delivery catheter into a left ventricle such that a distal portion of the delivery catheter is adjacent to an inferior surface of a posterior mitral leaflet in the patient body;

positioning at least one support member having at least one attractive element thereon with a first polarity adjacent to the inferior surface of the posterior mitral leaflet via the delivery catheter;

intravascularly advancing a guiding catheter into a coronary sinus such that a distal portion of the guiding catheter is adjacent to a mitral valve in a patient body;

positioning at least one anchoring element with a second polarity opposite to the first polarity within the coronary sinus via the guiding catheter such that the at least one support member and anchoring element are magnetically engaged with one another; and

expanding the at least one support member against the inferior surface of the posterior mitral leaflet such that prolapse of the leaflet is inhibited.

28. The method of claim 27 wherein intravascularly advancing a delivery catheter comprises advancing the delivery catheter until a magnetic element positioned on a distal tip on the delivery catheter is attracted to a corresponding magnetic element positioned on a distal tip of the guiding catheter.

29. The method of claim 27 wherein intravascularly advancing a delivery catheter further comprises anchoring the delivery catheter via an inflatable balloon at its distal tip.

30. The method of claim 27 wherein expanding comprises inflating one or more balloon members against the inferior surface of the posterior mitral leaflet.

31. The method of claim 30 further comprising expanding at least one stent member within each of the balloon members such that each stent maintains an expanded configuration of the balloon members.

32. The method of claim 27 wherein expanding comprising inflating at least three balloon members independently of one another against the inferior surface.

33. The method of claim 31 wherein expanding comprises adjusting an inflation of one or more balloon members.

34. The method of claim 27 further comprising releasing a coupling mechanism connecting the at least one support member to an outer catheter.

35. The method of claim 34 further comprising removing the outer catheter such that the at least one support member is magnetically retained against the inferior surface of the posterior mitral leaflet.

36. A method of supporting a posterior mitral leaflet, comprising:

positioning a ringed support member at least partially around a chordae tendineae supporting a mitral valve;

sliding the ringed support member along the chordae tendineae into a superior position against or adjacent to a posterior mitral leaflet during systole; and

sliding the ringed support member along the chordae tendineae into an inferior position towards a papillary muscle during diastole.

37. The method of claim 36 wherein sliding the ringed support member along the chordae tendineae into a superior position comprises urging the support member via tissue contractions and blood flow.