Expandable cartilage implant

• US 20080039954A1
• Filed: 08/08/2007
• Published: 02/14/2008
• Est. Priority Date: 08/08/2006
• Status: Abandoned Application

• Current Assignee: Howmedica Osteonics Corp. (Stryker Corporation)
• Original Assignee: Howmedica Osteonics Corp. (Stryker Corporation)
• Inventors: Long, Marc, Davisson, Twana
• Application Number:
  US11/891,057
• Publication Number:
  US 20080039954A1
• Time in Patent Office: Days
• US Class Current: 623/23.76
• CPC Class Codes: A61B 17/68 Internal fixation devices , including fasteners and spinal fixators, even if a part thereof projects from the skin bone staples A61B17/0642
• CPC Class Codes: A61B 17/86 Pins or screws or threaded wires; nuts therefor A61B17/72 take precedence
• CPC Class Codes: A61F 2/186 Nose parts
• CPC Class Codes: A61F 2/20 Epiglottis; Larynxes; Tracheae combined with larynxes or for use therewith tracheae, bronchi per se A61F2/04 ; tracheostomy tubes A61M16/0465
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2/3099 for temporo-mandibular [TM, TMJ] joints endoprostheses for mandibular reconstruction A61F2/2803
• CPC Class Codes: A61F 2/32 for the hip
• CPC Class Codes: A61F 2/38 for elbows or knees
• CPC Class Codes: A61F 2/3804 for elbows
• CPC Class Codes: A61F 2/40 for shoulders
• CPC Class Codes: A61F 2/4202 for ankles
• CPC Class Codes: A61F 2/4261 for wrists
• CPC Class Codes: A61F 2/44 for the spine, e.g. vertebrae, spinal discs
• CPC Class Codes: A61F 2002/046 Tracheae
• CPC Class Codes: A61F 2002/183 Ear parts
• CPC Class Codes: A61F 2002/2817 Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
• CPC Class Codes: A61F 2002/30062 (bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
• CPC Class Codes: A61F 2002/30075 swellable, e.g. when wetted
• CPC Class Codes: A61F 2002/30224 cylindrical
• CPC Class Codes: A61F 2002/30579 : with mechanically expandable devices, e.g. fixation devices
• CPC Class Codes: A61F 2002/30759 : Mosaicplasty, i.e. using a plurality of individual cartilage plugs for filling a substantial cartilage defect
• CPC Class Codes: A61F 2002/30764 : Cartilage harvest sites
• CPC Class Codes: A61F 2002/30996 : for sterno-clavicular joints
• CPC Class Codes: A61F 2002/4631 : the prosthesis being specially adapted for being cemented
• CPC Class Codes: A61F 2210/0004 : bioabsorbable
• CPC Class Codes: A61F 2210/0061 : swellable
• CPC Class Codes: A61F 2230/0069 : cylindrical
• CPC Class Codes: A61F 2310/00359 : Bone or bony tissue
• CPC Class Codes: A61L 2430/06 : for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 27/3608 : Bone, e.g. demineralised bone matrix [DBM], bone powder
• CPC Class Codes: A61L 27/3654 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/3804 : characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
• CPC Class Codes: A61L 27/3852 : Cartilage, e.g. meniscus
• CPC Class Codes: A61L 27/56 : Porous materials, e.g. foams or sponges

Abstract

The present invention relates to a method for repairing cartilage defects in a patient. According to the current invention, a porous material having at least expandable or compressible properties is implanted into a cartilage defect.

Claims

1. A method for repair of a cartilage defect in a patient in need thereof comprising implanting a graft into said cartilage defect, wherein said graft comprises a porous material, wherein said material is expandable or compressible.

2. The method of claim 1, wherein said material comprises a material selected from the group consisting of demineralized bone matrix, allogenic tissue, xenogenic tissue, and synthetic material.

3. The method of claim 1, wherein said material is expandable.

4. The method of claim 3, wherein said material is expandable by at least 10%.

5. The method of claim 1, wherein said material is compressible.

6. The method of claim 5, wherein said material is compressible by at least 10%.

7. The method of claim 1, wherein said graft further comprises at least one biological agent.

8. The method of claim 1, wherein said implantation is performed before, after, or at the same time as a procedure selected from the group consisting of mosaicplasty, autograft, or allograft.

9. The method of claim 1, wherein said material is both expandable and compressible.

10. The method of claim 1, wherein said graft further comprises cells.

11. The method of claim 10, wherein said cells are selected from the group consisting of mesenchymal stem cells, chondrocytes, osteoblasts, and chondroblasts.

12. The method of claim 10, wherein said cells are added to said material prior to implantation, at the time of implantation, or after implantation.

13. The method of claim 12, wherein said cells are cultured ex vivo with said material prior to implantation.

14. The method of claim 1, where said defect is located in a site selected from the group consisting of knee, ankle, hip, shoulder, elbow, temporomandibular, sternoclavicular, zygapophyseal, wrist, ear, nose, ribs, spinal column, pelvis, epiglottis, larynx, and windpipe.

15. The method of claim 1, where said material is compressed to a smaller size than the defect to be repaired prior to implantation.

16. The method of claim 1, wherein said material expands to substantially fill the defect on implantation.

17. The method of claim 1, wherein said material is press fit into the defect.

18. The method of claim 1, wherein said material is fixed to the defect with an anchor.

19. The method of claim 18, wherein said anchor is selected from the group consisting of glue, adhesive, a screw, and a nail.

20. The method of claim 1, wherein said graft is hydrated prior to implantation, at the time of implantation, or after implantation.