AEROSOL FORMULATION FOR THE INHALATION OF BETA AGONISTS
First Claim
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1. Medicament formulation comprising:
- as active substance one or more compounds of general formula 1Wherein R1 denotes hydrogen, C1-4-alkyl, O—
C1-4-alkyl or halogen;
R2 denotes hydrogen, C1-4-alkyl, O—
C1-4-alkyl or halogen;
R3 denotes hydrogen, C1-4-alkyl, O—
C1-4-alkyl, halogen, OH, —
O—
C1-4-alkylene-COOH or O—
C1-4-alkylene-COO—
C1-4-alkyl;
X−
denotes a mono- or polysubstituted negatively charged anion;
an active substance 2 selected from budesonide, beclomethasone, fluticasone and ciclesonide, or a metabolite thereof;
an active substance 3 selected from tiotropium salts, oxitropium salts, flutropium salts, ipratropium salts, glycopyrronium salts and trospium salts; and
at least one pharmacologically acceptable acid.
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Abstract
The present invention relates to a propellant-free aerosol formulation which contains one or more compounds of general formula 1,
wherein the groups R1, R2, R3 and X− may have the meanings indicated in the claims and in the specification, and two further active substances 2 and 3, for inhalation.
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Citations
35 Claims
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1. Medicament formulation comprising:
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as active substance one or more compounds of general formula 1 Wherein R1 denotes hydrogen, C1-4-alkyl, O—
C1-4-alkyl or halogen;
R2 denotes hydrogen, C1-4-alkyl, O—
C1-4-alkyl or halogen;
R3 denotes hydrogen, C1-4-alkyl, O—
C1-4-alkyl, halogen, OH, —
O—
C1-4-alkylene-COOH or O—
C1-4-alkylene-COO—
C1-4-alkyl;
X−
denotes a mono- or polysubstituted negatively charged anion;
an active substance 2 selected from budesonide, beclomethasone, fluticasone and ciclesonide, or a metabolite thereof;
an active substance 3 selected from tiotropium salts, oxitropium salts, flutropium salts, ipratropium salts, glycopyrronium salts and trospium salts; and
at least one pharmacologically acceptable acid. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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Specification