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EphA2 BiTE molecules and uses thereof

  • US 20080044413A1
  • Filed: 12/21/2006
  • Published: 02/21/2008
  • Est. Priority Date: 12/21/2005
  • Status: Abandoned Application
First Claim
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1. A bispecific single chain antibody comprising:

  • (a) a first heavy chain variable domain (VH domain) and a first light chain variable domain (VL domain) each from an antibody that immunospecifically binds to CD3, said first VH domain covalently linked to said first VL domain by a first linker of sufficient length such that said first VH domain and said first VL domain fold to form a first binding domain that binds to CD3; and

    (b) a second VH domain and a second VL domain from an antibody that immunospecifically binds an epitope of EphA2 exposed on the cell surface, said second VH domain covalently linked to said second VL domain by a second linker of sufficient length such that said second VH domain and said second VL domain fold to form a second binding domain that binds said epitope of EphA2;

    wherein said first binding domain and said second binding domain are covalently linked by a third linker of a sufficient length such that said first binding domain and said second binding domain fold independently of each other.

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