Method and system for cardiovascular system diagnosis
First Claim
1. A method for monitoring function and/or diagnosing dysfunction of the cardiovascular system of a subject, comprising obtaining pulse wave signals of said subject during periodic excitation of said cardiovascular system;
- analyzing frequency components of said signals; and
computing based on said frequency components an indicator reflecting a cardiovascular response to said periodic excitation.
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Abstract
The present invention is directed to a method and system for monitoring function and/or diagnosing dysfunction of the cardiovascular system of a human subject. The method comprise measuring pulse wave signals of the subject during rapid excitation of the cardiovascular system, analyzing the measured signals and computing indicators reflecting a response to said excitation. The cardiovascular excitation preferably comprise a controlled breathing protocol characterized by a predefined frequency of breaths (e.g., about 0.1 Hz).
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Citations
29 Claims
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1. A method for monitoring function and/or diagnosing dysfunction of the cardiovascular system of a subject, comprising
obtaining pulse wave signals of said subject during periodic excitation of said cardiovascular system; -
analyzing frequency components of said signals; and
computing based on said frequency components an indicator reflecting a cardiovascular response to said periodic excitation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. A method for computing a cardiovascular system indicator of a subject comprising:
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obtaining measurements of a sequence of breath signals and a corresponding sequence of pulse wave signals;
computing a period of said breath signals based on time between consecutive breaths taken by said subject;
locating within the period of any of said consecutive breaths a predefined number of consecutive breaths having a variation in conjoint mean period of less than a predefined value;
calculating a frequency of said conjoint mean period; and
computing a respiratory modulation response indicator around said calculated frequency. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for validating proper execution of a breathing protocol by a subject comprising:
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obtaining a pulse wave signal of the subject, at least part of said pulse wave signal being acquired during performance of a breathing protocol executed by said subject;
computing a beat rate waveform corresponding to said pulse wave signal;
computing a first power spectrum corresponding to said beat rate waveform; and
determining whether said first power spectrum includes a first power peak, wherein said first power peak is bounded by a predefined first frequency range. - View Dependent Claims (23, 24, 25, 26)
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27. A method for computing a respiratory modulation response (RMR) indicator comprising:
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obtaining a pulse wave signal of a subject;
computing a power spectrum corresponding to said pulse wave signal;
locating one or more power peaks in said power spectrum, wherein said power peaks correspond to harmonic frequencies of a predefined frequency;
computing at least one respiratory modulation response (RMR) indicator corresponding to a respective at least one of said power peaks; and
computing a conjoint RMR indicator corresponding to said at least one RMR indicators. - View Dependent Claims (28, 29)
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Specification