Nanoparticle Mediated Ultrasound Therapy and Diagnostic Imaging
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Abstract
The present invention relates to systems and methods for localized delivery of heat, useful for localized imaging and treatment of a biological material. The systems and methods of the invention can be utilized for localized treatment of cancer, inflammation or other disorders involving over proliferation of tissue, and for tissue repair. The method comprises exposing nanoparticles to electromagnetic radiation under conditions wherein the nanoparticles generate microbubbles which emit heat when exposed to ultrasonic radiation.
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Citations
135 Claims
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1-73. -73. (canceled)
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74. A system for localized delivery of heat to a cell or a tissue preloaded with nanoparticles comprising:
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a. an electromagnetic radiation source configured to irradiate the nanoparticles to induce the production of microbubbles by said nanoparticles;
b. a therapeutic ultrasonic wave generating source configured to irradiate the microbubbles as to induce heat production by said microbubbles; and
c. driving means coupled to the therapeutic ultrasonic wave generating source for driving said therapeutic ultrasonic source with a drive signal to generate therapeutic ultrasonic waves. - View Dependent Claims (75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89)
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90. A method for inducing localized delivery of heat to a cell or a tissue comprising:
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a. administering a plurality of nanoparticles to the cell or tissue;
b. irradiating the nanoparticles administered to said cell or tissue by electromagnetic radiation, as to induce the production of microbubbles; and
c. exposing the microbubbles of step (b) to ultrasound radiation;
wherein said microbubbles emit heat upon exposure to the ultrasound radiation. - View Dependent Claims (91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122)
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123. An ultrasonic imaging system for diagnosing a cell or a tissue preloaded with nanoparticles comprising:
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a. an electromagnetic radiation source configured to irradiate the nanoparticles to induce the production of microbubbles by said nanoparticles;
b. at least one imaging ultrasonic wave generating source configured to irradiate the microbubbles as to enhance the ultrasound imaging contrast of said cell or tissue administered with said nanoparticles;
an ultrasound probe;
c. driving means coupled to the imaging ultrasonic wave generating source for driving said imaging ultrasonic source with a drive signal to generate imaging ultrasonic waves; and
d. an ultrasound probe. - View Dependent Claims (124, 125, 126, 127, 128, 129, 130, 131, 132)
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133. A method for ultrasonic imaging of a cell or a tissue, comprising:
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a. administering nanoparticles to the cell or tissue;
b. irradiating the nanoparticles administered to said cell or tissue by electromagnetic radiation, as to induce the production of microbubbles; and
c. exposing the microbubbles of step (b) to ultrasound radiation;
wherein said microbubbles enhance the ultrasound imaging contrast of said cell or tissue administered with said nanoparticles. - View Dependent Claims (134, 135)
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Specification