MOVING MICRODROPLETS IN A MICROFLUIDIC DEVICE
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Accused Products
Abstract
The present invention relates to a system and method for moving samples, such as fluid, within a microfluidic system using a plurality of gas actuators for applying pressure at different locations within the microfluidic. The system includes a substrate which forms a fluid network through which fluid flows, and a plurality of gas actuators integral with the substrate. One such gas actuator is coupled to the network at a first location for providing gas pressure to move a microfluidic sample within the network. Another gas actuator is coupled to the network at a second location for providing gas pressure to further move at least a portion of the microfluidic sample within the network. A valve is coupled to the microfluidic network so that, when the valve is closed, it substantially isolates the second gas actuator from the first gas actuator.
189 Citations
46 Claims
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1-28. -28. (canceled)
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29. A system, comprising:
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a microfluidic device;
a computer-controlled heat source; and
a detector wherein the microfluidic device comprises;
an upstream channel;
a DNA manipulation zone located downstream from the upstream channel;
a first valve disposed within the DNA manipulation zone;
a second valve disposed within the DNA manipulation zone; and
a vent disposed within the DNA manipulation zone and separated from the upstream channel by the first and second valves;
wherein the computer-controlled heat source is in thermal contact with the DNA manipulation zone; and
wherein the detector is configured to identify one or more polynucleotides within the DNA manipulation zone. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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46. A device, comprising:
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a microfluidic component;
a computer-controlled heat source; and
a detector;
wherein the microfluidic component comprises;
a channel;
a first valve in communication with the channel, and configured to close or open the channel;
a second valve in communication with the channel, and configured to close or open the channel; and
a vent separated from the first valve by the second valve;
wherein the computer-controlled heat source is in thermal contact with the channel; and
wherein the detector is configured to identify one or more polynucleotides within the channel.
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Specification