Novel human kinases and polynucleotides encoding the same

• US 20080050809A1
• Filed: 06/23/2005
• Published: 02/28/2008
• Est. Priority Date: 09/28/1999
• Status: Abandoned Application

• Current Assignee: Lexicon Genetics, Incorporated
• Original Assignee: Lexicon Genetics, Incorporated
• Inventors: Wang, Xiaoming, Xie, Amy Qiongshu, Mathur, Daniel, Wilganowski, Nathaniel L., Walke, D. Wade, Friddle, Carl Johan, Kieke, James Alvin, Mathur, Brian, Turner, C. Alexander, Nehls, Michael C., Sands, Arthur T., Hu, Yi, Zambrowicz, Brian, Yu, Xuanchuan, Scoville, John, Abuin, Alejandro, Friedrich, Glenn, Hilbun, Erin, Nepomnichy, Boris, Donoho, Gregory, Gerhardt, Brenda, Miranda, Maricar
• Application Number:
  US11/165,424
• Publication Number:
  US 20080050809A1
• Time in Patent Office: Days
• US Class Current: 435/325
• CPC Class Codes: C12N 9/1205 Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule that encodes the amino acid sequence of SEQ ID NO:

2, 4, 6, 8, 10, 12, 15, 17, 19, 22, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 75, 77, 80, 83, 85, 87, 89, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 161, 163, 165, 167, 169, 172, 174, 177, 179, 181, 183, 186, 188, 191, 194, 196, 198, 200, 202, 204, 206, 208, 210, 212, 214, 216, 218, 220, 222, 224, 226, 228, 230, 232, 234, 236, 238, 240, 242, 244, 246, 249, 251, 253, 255, 257, 259, 261, 263, 265, 267, 269, 271, 273, 275, or 278.

2. The isolated nucleic acid molecule of claim 1, wherein said nucleic acid molecule comprises the nucleotide sequence of SEQ ID NO:

1, 3, 5, 7, 9, 11, 14, 16, 18, 21, 24, 26, 28, 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 74, 76, 79, 82, 84, 86, 88, 91, 93, 95, 97, 99, 101, 103, 105, 107, 109, 111, 113, 115, 117, 119, 121, 123, 125, 127, 129, 131, 133, 135, 137, 139, 141, 143, 145, 147, 149, 151, 153, 155, 157, 160, 162, 164, 166, 168, 171, 173, 176, 178, 180, 182, 185, 187, 190, 193, 195, 197, 199, 201, 203, 205, 207, 209, 211, 213, 215, 217, 219, 221, 223, 225, 227, 229, 231, 233, 235, 237, 239, 241, 243, 245, 248, 250, 252, 254, 256, 258, 260, 262, 264, 266, 268, 270, 272, 274, or 277.

3. An expression vector comprising the isolated nucleic acid molecule of claim 1.

4. (canceled)

5. An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:

2, 4, 6, 8, 10, 12, 15, 17, 19, 22, 25, 27, 29, 31, 33, 35, 37, 39, 41, 43, 45, 47, 49, 51, 53, 55, 57, 59, 61, 63, 65, 67, 69, 71, 75, 77, 80, 83, 85, 87, 89, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 134, 136, 138, 140, 142, 144, 146, 148, 150, 152, 154, 156, 158, 161, 163, 165, 167, 169, 172, 174, 177, 179, 181, 183, 186, 188, 191, 194, 196, 198, 200, 202, 204, 206, 208, 210, 212, 214, 216, 218, 220, 222, 224, 226, 228, 230, 253, 255, 257, 259, 261, 263, 265, 267, 269, 271, 273, 275, or 278.