USE OF 4-AMINO-PIPERIDINES FOR TREATING SLEEP DISORDERS
First Claim
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1. A method of increasing slow-wave sleep comprising administering N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide to a subject in need of increased slow wave sleep in an amount sufficient to increase slow wave sleep.
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Abstract
Inverse agonists and antagonists of serotonin receptors are disclosed for use in treating sleep disorders such as insomnia, and specifically sleep maintenance insomnia. The compound increase slow wave sleep, decrease the number of awakenings after sleep onset, and decrease the time awake after sleep onset.
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Citations
54 Claims
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1. A method of increasing slow-wave sleep comprising administering N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide to a subject in need of increased slow wave sleep in an amount sufficient to increase slow wave sleep.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of treating insomnia comprising administering N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide to a subject suffering from insomnia in an amount sufficient to ameliorate insomnia.
- View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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40. A method for decreasing the number of awakenings after sleep onset comprising administering N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide to a subject in need of a decreased number of awakenings after sleep onset in an amount sufficient to decrease the number of awakenings after sleep onset.
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41. A method for decreasing the time awake after sleep onset comprising administering N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide to a subject in need of decreased time awake after sleep onset in an amount sufficient to decrease time awake after sleep onset.
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42. A method of manufacturing a pharmaceutical composition, said method comprising:
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obtaining a first dosage form comprising a first amount of N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
-(4-(2-methylpropyloxy)phenylmethyl)carbamide;
obtaining a second dosage form comprising a second amount of N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
-(4-(2-methylpropyloxy)phenylmethyl)carbamide; and
packaging together said first dosage form and said second dosage form. - View Dependent Claims (43, 44)
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45. A packaged pharmaceutical composition, comprising N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide in a container and instructions for using N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
-(4-(2-methylpropyloxy)phenylmethyl)carbamide to treat insomnia.
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide in a container and instructions for using N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
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46. A packaged pharmaceutical composition, comprising N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide in a container and instructions for using N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
-(4-(2-methylpropyloxy)phenylmethyl)carbamide to increase slow wave sleep, decrease the number of awakenings after sleep onset or decrease the time awake after sleep onset.
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide in a container and instructions for using N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
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47. A kit comprising a first dosage form of N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide and a second dosage form of N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
-(4-(2-methylpropyloxy)phenylmethyl)carbamide. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54)
- -(4-(2-methylpropyloxy)phenylmethyl)carbamide and a second dosage form of N-(1-methylpiperidin-4-yl)-N-(4-fluorophenylmethyl)-N′
Specification