Acyloxyalkyl carbamate prodrugs of alpha-amino acids, methods of synthesis and use
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Abstract
Acyloxyalkyl carbamate prodrugs of α-amino acids, pharmaceutical compositions thereof, methods of making acyloxyalkyl carbamate prodrugs of α-amino acids and methods of using acyloxyalkyl carbamate prodrugs of α-amino acids, and pharmaceutical compositions thereof to treat a disease are disclosed. Acyloxyalkyl carbamate prodrugs of α-amino acids suitable for oral administration using sustained release dosage forms are also disclosed.
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Citations
36 Claims
- 1. A compound of Formula (I):
- 23. A pharmaceutical composition comprising at least one pharmaceutically acceptable vehicle and at least one compound of Formula (I):
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29. A method of synthesizing a compound of Formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of any of the foregoing, comprising contacting a compound of Formula (II) with a compound of Formula (III) to provide the compound of Formula (I):
- 30. A method of treating a disease in a patient comprising administering to a patient in need of such treatment a pharmaceutical composition comprising a therapeutically effective amount of at least one compound of Formula (I):
Specification