DEVICE AND METHOD FOR THE TRANSDERMAL STIMULATION OF A NERVE OF THE HUMAN BODY

• US 20080051852A1
• Filed: 10/31/2007
• Published: 02/28/2008
• Est. Priority Date: 01/21/2006
• Status: Abandoned Application

• Current Assignee: Cerbomed GmbH (tVNS Technologies GmbH)
• Original Assignee: Cerbomed GmbH (tVNS Technologies GmbH)
• Inventors: DIETRICH, Stefan, FREITAG, Timo
• Application Number:
  US11/931,821
• Publication Number:
  US 20080051852A1
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61H 2205/027 Ears
• CPC Class Codes: A61H 39/002 Using electric currents electrotherapy A61N1/32
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0472 Structure-related aspects
• CPC Class Codes: A61N 1/0541 Cochlear electrodes
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/36017 with leads or electrodes penetrating the skin
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

The invention relates to a device for transdermal stimulation of a nerve of the human body, which device comprises at least one stimulation electrode and at least one reference electrode for transdermal nerve stimulation, the at least one stimulation electrode and the at least one reference electrode being connected to a control unit and being able to be supplied with an electrical current from the latter, and the at least one stimulation electrode and the at least one reference electrode being arranged in or on a housing which is designed to be fitted on or in the human ear. The invention further relates to a method for the transdermal stimulation of a nerve of the human body in particular of a part of the vagus nerve by applying an electrical stimulus via at least one stimulation electrode and at least one reference electrode, at least one of which is placed in contact with the skin surface of the inner face of the Tragus of the human ear. The invention further relates to transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear for the treatment and/or supportive therapy of a plurality of pathological conditions.

Claims

1. Device for transdermal stimulation of a nerve of the human body, which device comprises at least one stimulation electrode and at least one reference electrode for transdermal nerve stimulation, the at least one stimulation electrode and the at least one reference electrode being connected to a control unit and being able to be supplied with an electrical current from the latter, and the at least one stimulation electrode and the at least one reference electrode being arranged in or on a housing which is designed to be fitted on or in the human ear, characterized in that the housing has a bow-shaped extension piece designed to be inserted into the auditory canal, said bow-shaped extension piece matching the shape of the entrance to the auditory canal or of the external auditory canal, and with an electrode head which is arranged at the end of the bow-shaped extension piece and which has two contact points for the two electrodes.

2. Device according to claim 1, characterized in that it is designed and suitable for stimulation of the vagus nerve in the area of the external auditory canal and/or the auricle.

3. Device according to claim 1, characterized in that the control unit is arranged in the housing.

4. Device according to claim 1, characterized in that the control unit is removable from the housing and is connected to the electrodes.

5. Device according to claim 4, characterized in that the connection is a wired connection.

6. Device according to claim 4, characterized in that the connection is wireless, and in particular is a radio connection.

7. Device according to one of claim 1, characterized in that the electrode head is made of a soft material, in particular of permanently soft silicone.

8. Device according to one of claim 1, characterized in that the contact points are formed by metal balls.

9. Device according to one of claim 1, characterized in that the contact points (8, 9) are formed by flat surface electrodes.

10. Device according to one of claim 1, characterized in that the contact points (8, 9) are formed by an element made of a material with electrical surface conductivity, in particular of a sponge with graphite inserts.

11. Device according to one of claim 1, characterized in that the control unit is able to influence the frequency of an alternating current flowing through the electrodes.

12. Device according to one of claim 1, characterized in that the control unit is able to influence the level of the current flowing through the electrodes.

13. Device according to one of claim 1, characterized in that the control unit is able to influence the length of impulses of the current flowing through the electrodes.

14. Device according to one of claim 1, characterized in that the control unit is able to influence the stimulation time intervals of the current flowing through the electrodes.

15. Device according to one of claim 1, characterized in that the control unit is able to influence the time profile of the current flowing through the electrodes.

16. Device according to one of claim 1, characterized in that a rechargeable battery is arranged in the device and supplies current to the control unit.

17. Device according to one of claim 1, characterized in that it comprises a sensor for measuring a physiological parameter of the patient.

18. Device according to claim 17, characterized in that the physiological parameter is the patient'"'"'s pulse.

19. Device according to claim 17, characterized in that the physiological parameter is the oxygen saturation of the patient'"'"'s blood.

20. Device according to one of claim 17, characterized by a memory chip for storing the data measured by means of the sensor.

21. Device according to one of claim 1, characterized in that the electrodes are integrated into the earpiece, or into the headset of a hands-free mobile telephone unit, and in that the control unit is integrated into a mobile telephone.

22. Device according to claim 21, characterized in that the connection between electrodes and control unit is established via a radio connection, in particular via a Bluetooth connection or a WLAN connection.

23. Device according to one of claim 1, characterized in that the electrodes are integrated into the headphones of a music playback system, and in that the control unit is integrated into the music playback system.

24. Method for the transdermal stimulation of a nerve of the human body in particular of a part of the vagus nerve by applying an electrical stimulus via at least one stimulation electrode and at least one reference electrode, at least one of which is placed in contact with the skin surface of the inner face of the Tragus of the human ear.

25. Method according to claim 24, wherein the electrical stimulus is an electrical current.

26. Method according to claim 25, wherein the electrical current is an alternating current and the frequency of said alternating current is controlled by a controlling unit.

27. Method according to claim 25, wherein the level of the current flowing through the electrodes is controlled by a controlling unit.

28. Method according to claim 25, wherein the length of impulses of the electrical current flowing through the electrodes is controlled by the controlling unit.

29. Method according to claim 25, wherein the stimulation time intervals of the electrical current flowing through the electrodes is controlled by the controlling unit.

30. Method according to claim 25, wherein the stimulation time profile of the electrical current flowing through the electrodes is controlled by the controlling unit.

31. Method according to claim 25, wherein the electrical current is controlled in relation to at least one physiological parameter being measured by at least one sensor.

32. Method according to claim 31, wherein the at least one physiological parameter being measured by the at least one sensor comprises the pulse rate.

33. Method according to claim 31, wherein the at least one physiological parameter being measured by the at least one sensor comprises the breathing rate.

34. Method according to claim 31, wherein the at least one physiological parameter being measured by the at least one sensor comprises the oxygen saturation of the blood.

35. Method according to claim 31, wherein at least one physiological parameter being measured by the at least one sensor is stored by a memory chip.

36. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of depressions and/or anxiety states.

37. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of neurological and/or psychiatric conditions or diseases.

38. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of affective disorders, bipolar disorders, borderline syndrome, personality disorder, schizophrenia, anxiety disorders and/or phobias.

39. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of tinnitus.

40. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of seizure disorders, in particular epilepsy.

41. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of drug addiction to smoking, alcohol, narcotics and/or other drugs.

42. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the support for the withdrawal from smoking, alcohol, narcotics and/or other drugs and/or for the alleviation of withdrawal symptoms.

43. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of eating disorders, in particular anorexia or bulimia.

44. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the support for loosing weight.

45. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of cognitive disorders and/or demential diseases in particular the Alzheimer'"'"'s disease.

46. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of pains, in particular chronic pains.

47. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the alleviation and/or control of pains, in particular chronic pains.

48. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of cardiac conditions and/or pathologies, in particular cardiac insufficiency, bradycardia, tachycardia, instability of heart rate, hypotension, hypertension, preventative therapy for and/or after-treatment of myocardial infarction.

49. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of endocrine disorders, in particular thyroid, adrenal and/or pancreatic disorders, particularly diabetes.

50. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of kinetic or movement disorders, in particular Parkinson'"'"'s disease, restless leg syndrome, hyperactivity, attention deficit, impaired control and/or Tourette'"'"'s syndrome.

51. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the treatment and/or supportive therapy of sleep disorders, in particular problems to fall asleep and of problems to sleep continuously, insomnia and/or hypersomnia and/or for the therapeutic control of sleep phases.

52. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for tranquilization in the case of excitation and in the case of stress.

53. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the increase of the capability of healthy people.

54. Method according to claim 24, wherein said transdermal stimulation of a part of the vagus nerve by electrical stimulation via the inner face of the Tragus of the human ear is for the improvement of the health of the heart.