AEROSOL CREATED BY DIRECTED FLOW OF FLUIDS AND DEVICES AND METHODS FOR PRODUCING SAME

• US 20080053436A1
• Filed: 10/30/2007
• Published: 03/06/2008
• Est. Priority Date: 06/11/1999
• Status: Abandoned Application

• Current Assignee: Aradigm Corporation, Universidad de Sevilla
• Original Assignee: Aradigm Corporation, Universidad de Sevilla
• Inventors: Rosell, Joan, Ganan-Calvo, Alfonso
• Application Number:
  US11/929,642
• Publication Number:
  US 20080053436A1
• Time in Patent Office: Days
• US Class Current: 128/203.15
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: A61M 15/0003 with means for dispensing more than one drug
• CPC Class Codes: B05B 1/005 Nozzles or other outlets specially adapted for discharging one or more gases
• CPC Class Codes: B05B 7/0408 with arrangements for mixing two or more liquids
• CPC Class Codes: B05B 7/0433 with one inner conduit of gas surrounded by an external conduit of liquid upstream the mixing chamber
• CPC Class Codes: B05B 7/0458 the gas and liquid flows being perpendicular just upstream the mixing chamber
• CPC Class Codes: B05B 7/0475 with means for deflecting the peripheral gas flow towards the central liquid flow B05B7/0458 takes precedence
• CPC Class Codes: F23D 11/104 intersecting at a sharp angle, e.g. Y-jet atomiser

Abstract

A method of creating small particles by a technology referred to here as “violent focusing” is disclosed, along with devices for generating such violent focusing. In general, the method comprises the steps of forcing a first fluid out of an exit opening of the feeding channel to create a fluid stream. The exit opening is positioned such that the fluid flowing out of the channel flows toward and out of an exit orifice of a pressure chamber which surrounds the exit opening of the feeding channel, and is filled with an atomizing fluid. An atomizing fluid such as a gas is directed towards the first fluid stream in approximately orthogonal directions and surrounding the circumference of the first fluid stream from all sides. The first fluid flow is broken into particles which have dimensions which are smaller than the dimensions of this fluid stream.

Claims

1-26. -26. (canceled)

27. A method of generating an aerosol, comprising the steps of:

forcing a liquid formulation comprised of a pharmaceutically active drug through a feeding supply channel and out of an exit opening;

filling a pressure chamber with a gas which chamber is in fluid connection with the exit opening of the feeding supply channel;

forcing the gas toward and into the liquid in a manner which destabilizes the liquid into particles having a diameter less than the diameter of the exit opening of the feeding supply channel; and

allowing the gas to exert force on the liquid and force particles of the liquid out of an exit orifice of the pressure chamber positioned downstream of a direction of flow of the liquid stream.

28. The method of claim 27, wherein the particles formed comprise particles of 1-5 micrometers in aerodynamic diameter.

29. The method of claim 28, further comprising:

inhaling the particles into a patient'"'"'s lungs.

30. The method of claim 29, wherein liquid of the particles evaporates leaving dry particles to be inhaled.

31. The method of claim 27, wherein the particles formed comprise particles of 1-3 micrometers in diameter.

32. The method of claim 27, wherein the gas is forced into the liquid at an angle in a range of from about 15°

C. to about 90°

to the liquid flow direction.

33. The method of claim 28, wherein the gas is forced into the liquid at an angle in a range of from about 45°

C. to about 90°

to the liquid flow direction.

34. The method of claim 29, wherein the gas is forced into the first liquid stream circumference at an angle in a range of from about 90±

5°

to the liquid flow direction.

35. The method of claim 27, wherein the energy source causes the gas to converge toward the liquid along streamlines that form an angle of 45°

or greater with respect to the liquid.

36. The method of claim 27, wherein the exit opening of the feeding supply channel has a diameter in the range of about 5 to about 10,000 microns.

37. The method of claim 29, wherein the exit opening of the feeding supply channel is positioned at a distance in a range of from about 5 to about 10,000 microns from the exit orifice of the pressure chamber.

38. The method of claim 28, wherein the exit opening of the pressure chamber has a diameter in the range of about 5 to about 10,000 micro-meters.

41. The method of claim 38, wherein the ratio of the exit opening of the feeding supply channel width to the pressure chamber exit orifice width is in the range of about 0.8 to about 1.0.

42. The method of claim 38, wherein the ratio of the separation between the exit opening of the feeding supply channel and the pressure chamber exit orifice, to the pressure chamber exit orifice width, is less than about 1.5.

43. The method of claim 38, wherein the ratio of the separation between the exit opening of the feeding supply channel and the pressure chamber exit orifice, to the pressure chamber exit orifice width, is in the range of is less than about 1.0.

44. The method of claim 38, wherein the ratio of the separation between the exit opening of the feeding supply channel and the pressure chamber exit orifice, to the pressure chamber exit orifice width is in the range of is in the range of about 0.2 to about 0.7.

45. The method of claim 38, wherein the exit opening of the feeding supply channel and the pressure chamber exit orifice are substantially circular.

46. The method of claim 38, wherein the gas is forced into the liquid by being forced through a channel, one wall of the channel having an angle to the centerline of the feeding supply channel in the range of about 75 to about 105 degrees.

47. The method of claim 38, wherein the exit orifice of the pressure chamber has a diameter in the range of about 15 to about 400 micro-meters.

48. The method of claim 38, wherein the exit opening of the feeding supply channel has a diameter in the range of about 15 to about 300 micrometers.

49. The method of claim 38, wherein the exit opening of the container is positioned at a distance in a range of from about 15 to about 300 micro-meters from the orifice in the pressure chamber.

50. The method of claim 38, wherein the gas is selected from the group consisting of air, nitrogen, carbon dioxide, helium, argon and mixtures thereof.

51. The method of claim 49, wherein the gas is comprised of carbon dioxide.

40. The method of claim 40, wherein the ratio of the exit opening of the feeding supply channel width to the pressure chamber exit orifice width is in the range of about 0.7 to about 1.2.

39. The method of claim 40, wherein the ratio of the exit opening of the feeding supply channel width to the pressure chamber exit orifice width is greater than about 0.5.