AEROSOL GENERATING AND DELIVERY DEVICE

• US 20080054099A1
• Filed: 08/30/2007
• Published: 03/06/2008
• Est. Priority Date: 08/30/2006
• Status: Active Grant

• Current Assignee: Savine Therapeutics Pty
• Original Assignee: Kurve Technology, Inc.
• Inventors: Kamp, Robert W., Rinne, Finn O., DeGroodt, William A., Giroux, Marc, Pearce, Joseph R., Leung, Paul C.
• Granted Patent: US 7,905,229 B2
• Time in Patent Office: Days
• US Class Current: 239/337
• CPC Class Codes: A61M 11/02 operated by air or other gas pressure applied to the liquid or other product to be sprayed or atomised sprayers for horticulture A01G, A01H; killing insects A01M; air humidifying by nozzles F24F6/14, F24F6/18; cooling by spraying F28B, F28C
• CPC Class Codes: A61M 15/0021 Mouthpieces therefor
• CPC Class Codes: A61M 15/009 using medicine packages with incorporated spraying means, e.g. aerosol cans pocket atomiser of the injector type A61M11/08
• CPC Class Codes: A61M 15/08 Inhaling devices inserted into the nose
• CPC Class Codes: A61M 35/003 Portable hand-held applicators having means for dispensing or spreading integral media hand-held massage devices with liquid delivery A61H7/003
• CPC Class Codes: B05B 7/0012 Apparatus for achieving spraying before discharge from the apparatus
• CPC Class Codes: B05B 7/0869 the liquid or other fluent material being sucked or aspirated from an outlet orifice by another fluid, e.g. a gas, coming from another outlet orifice
• CPC Class Codes: B05B 7/2429 the carried liquid and the main stream of atomising fluid being brought together after discharge B05B7/2435 takes precedence

Abstract

Particular aspects provide novel atomizers for generating particles over a broad range of MMAD size distributions, the eliminating the requirement for an impaction baffle in generating the desired particle sizes. In particular aspects, the atomization means communicates with a remote particle filter member configured and positioned to provide for particle size filtering. In additional aspects, the atomization means communicates with a particle dispersion chamber suitable to impart a desired particle flow pattern to particles within and exiting the dispersion chamber. In further aspects, the atomization means communicates with a nasal, ocular, oral or ‘vicinity’ adapter. The novel devices provide for targeted (e.g., nasal, ocular, oral, local vicinity), systemic, and/or topical delivery of an atomized liquid (e.g., via the nasal cavity, olfactory region, and mouth). Further exemplary aspects relate to aerosolization and delivery of perfume, fragrance, essential oil or cosmeceutical agents and the like.

Claims

1. An aerosol generating device comprising:

an upright liquid feed tube having a liquid exit orifice and a sidewall; and

an upright compressed fluid feed channel having a compressed fluid exit orifice, the compressed fluid exit orifice being spaced from a portion of the sidewall, the compressed fluid exit orifice being configured to direct a stream of compressed fluid toward the portion of the sidewall, the portion of the sidewall being configured to disrupt a portion of the stream of compressed fluid, the disrupted portion of the stream of compressed fluid being configured to atomize a liquid from the liquid exit orifice.

2. The device of claim 1, wherein the atomized liquid comprises particles, and the device further comprises a filtering member configured aerodynamically to filter particles from the atomized liquid having a size greater than a predetermined maximum size.

3. The device of claim 1, further comprising a particle dispersion chamber configured to receive the atomized liquid and impart a predetermined flow pattern thereto.

4. The device of claim 3, wherein the predetermined flow pattern is vortical.

5. The device of claim 1, wherein the upright liquid feed tube comprises a liquid supply member comprising a liquid feed channel, the feed channel having an inlet, a liquid supply member exit orifice, and a supply member end-wall face having an outside diameter disposed about the liquid supply member exit orifice, the liquid supply member feed channel defining a projected axis L,

wherein the end wall face liquid feed channel exit orifice is separated by a distance of at least H from the compressed fluid channel exit orifice, H being measured along a projected axis F that is normal to a plane P defined by the compressed fluid channel exit orifice,

H is equal to or greater than ¼

, ½

or 1×

the inner diameter D1 of the compressed fluid channel adjacent the compressed fluid channel exit orifice, the projected longitudinal axis L intersects the projected axis F at a right, acute or obtuse angle, defining an intersection plane I, and wherein

at the distance H along projected axis F, the plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected axis F, S being equal to or less than 2×

the inner diameter D1 of the primary compressed fluid channel.

6. The device of claim 1, wherein the liquid comprises at least one selected from the group consisting of medicaments, small or large molecule pharmaceutical agents, liquids, solutions, suspensions, emulsions, perfumes, fragrances, essential oils, cosmeceutical agents, oils, cosmeceutical agents, moisturizing agents, water, lotions, air fresheners, deionizing agents, aromatherapeutic agents, beverages, and skin treatments.

7. The device of claim 1, further comprising a nasal, ocular, oral or ‘

vicinity’

adapter in communication with the atomization means.

8. An aerosol generating device comprising:

a reservoir configured to hold a liquid;

a liquid supply member comprising a diverting portion and a feed channel, the feed channel having an inlet in communication with the reservoir and an liquid supply member exit orifice, the feed channel being configured to draw liquid from the reservoir and transport it to the exit aperture for aerosolization therefrom by a compressed fluid; and

a compressed fluid supply member comprising a compressed fluid channel having an exit orifice, the diverting portion being located between the exit orifice of the feed channel and the exit orifice of the compressed fluid channel, the compressed fluid channel being configured to receive a compressed fluid and conduct a portion of the compressed fluid through the exit orifice and into engagement with the diverting portion of the liquid supply member, the portion of the compressed fluid engaging the diverting portion being diverted by the diverting portion before aerosolizing the liquid from the exit aperture of the feed channel.

9. The device of claim 8, wherein the compressed fluid channel and the diverting portion are configured such that a second portion of the compressed fluid conducted through the compressed fluid exit orifice does not engage the diverting portion of the liquid supply member.

10. The device of claim 8, wherein the diverting portion has a surface, the portion of the compressed fluid engaging the diverting portion engages the surface of the diverting portion, and the surface is configured to divert the portion of the compressed fluid engaging it non-uniformly.

11. The device of claim 8, wherein the liquid supply member comprises a tube section, the feed channel comprises a first portion disposed inside the tube section, the exit aperture of the feed channel is formed in the tube section, and the tube section comprises an outside surface, and the diverting portion comprises a portion of the outside surface of the tube section located between the exit orifice of the feed channel and the exit orifice of the compressed fluid channel.

12. The device of claim 8, wherein the portion of the compressed fluid conducted through the compressed fluid exit orifice exits the orifice along an axis “

F,”

the liquid feed channel has a longitudinal axis “

L,” and

the axis “

F”

intersects the axis “

L.”

13. The device of claim 8, wherein the liquid supply member comprises an anchor portion and a free end portion,

the anchor portion is located between the inlet of the liquid supply member and the exit orifice of the liquid supply member,

the anchor portion is coupled to the compressed fluid supply member;

and

the free end portion comprises the inlet of the liquid supply member and is supported by the anchor portion within the reservoir.

14. The device of claim 8, further comprises a particle dispersion chamber configured to impart a flow pattern to the aerosolized liquid.

15. The device of claim 8, comprising a supply member end-wall face having an outside diameter disposed about the liquid supply member orifice, wherein the liquid supply member feed channel defines a projected axis L,

the end wall face and the orifice are separated by a distance of at least H from compressed fluid channel exit orifice, H being measured along a projected axis F that is normal to a plane P defined by the compressed fluid channel exit orifice,

H is equal to or greater than ¼

, ½

or 1×

the inner diameter D1 of the compressed fluid channel adjacent the compressed fluid channel exit orifice,

the projected longitudinal axis L intersects the projected axis F at a right, acute or obtuse angle, defining an intersection plane I, and wherein

at the distance H along projected axis F, the plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected axis F, S being equal to or less than 2×

the inner diameter D1 of the primary compressed fluid channel.

16. The device of claim 8, wherein the liquid for which the reservoir is configured to hold comprises at least one selected from the group consisting of medicaments, small or large molecule pharmaceutical agents, liquids, solutions, suspensions, emulsions, perfumes, fragrances, essential oils, cosmeceutical agents, oils, cosmeceutical agents, moisturizing agents, water, lotions, air fresheners, deionizing agents, aromatherapeutic agents, beverages, and skin treatments.

17. The device of claim 8, further comprising a nasal, ocular, oral or ‘

vicinity’

adapter in communication with the atomization means.

18. An aerosol generating device comprising:

a reservoir configured to hold a liquid;

a liquid supply member comprising a feed channel comprising;

a first portion with a first diameter and an exit orifice, and

a second portion with a second diameter and an inlet aperture in communication with the reservoir, the first portion diameter being smaller than the second portion diameter, the feed channel being configured to draw liquid from the reservoir into the inlet aperture of the second portion and transport it to the exit orifice of the first portion for aerosolization therefrom by a compressed fluid; and

a compressed fluid supply member comprising a compressed fluid channel and compressed fluid channel exit orifice configured to direct a compressed fluid flow passed the exit orifice of the first portion of the feed channel thereby aerosolizing the liquid therefrom.

19. The device of claim 18, wherein the liquid held in the reservoir has a surface, at least a portion of the liquid supply member is located inside the reservoir, a first section of the second portion is below the surface of the liquid, and a second section of the second portion is above the surface of the liquid.

20. The device of claim 18, comprising a supply member end-wall face having an outside diameter disposed about the liquid supply member orifice, wherein the liquid supply member feed channel first portion defines a projected axis L,

the end wall face and the orifice are separated by a distance of at least H from compressed fluid channel exit orifice, H being measured along a projected axis F that is normal to a plane P defined by the compressed fluid channel exit orifice,

H is equal to or greater than ¼

, ½

or 1×

the inner diameter D1 of the compressed fluid channel adjacent the compressed fluid channel exit orifice,

the projected longitudinal axis L intersects the projected axis F at a right, acute or obtuse angle, defining an intersection plane I, and wherein

at the distance H along projected axis F, the plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected axis F, S being equal to or less than 2×

the inner diameter D1 of the primary compressed fluid channel.

21. The device of claim 18, wherein the liquid for which the reservoir is configured to hold comprises at least one selected from the group consisting of medicaments, small or large molecule pharmaceutical agents, liquids, solutions, suspensions, perfume, fragrance, essential oil or cosmeceutical agents, oils, cosmeceutical agents, moisturizing agents, water, lotions, air fresheners, deionizing agents and skin surface treatments.

22. The device of claim 18, further comprising a nasal, ocular, oral or ‘

vicinity’

adapter.

23. An aerosolization device having an aerosolization assembly configured to produce a stream of aerosolized particles from a liquid stored in a reservoir, the device comprising:

a filtering member spaced apart from the aerosolization assembly and located within the stream of aerosolized particles, the filtering member being configured aerodynamically to separate the aerosolized particles within the stream of aerosolized particles having a size greater than a predetermined size from the aerosolized particles within the stream of aerosolized particles having a size less than or equal to the predetermined size, to collect the aerosolized particles having a size greater than a predetermined size and return them to the reservoir, and to permit the aerosolized particles having a size less than or equal to the predetermined size to pass thereby.

24. The device of claim 23, wherein the filtering member is configured aerodynamically to avoid collisions with the aerosolized particles of the stream of aerosolized particles.

25. The device of claim 23, wherein at least 20%, at least 30%, at least 40%, at least 50%, or at least 60% of the aerosolized particles within the stream of aerosolized particles pass by the filtering member without colliding therewith.

26. The device of claim 23, further comprising a particle dispersion chamber configured to receive the particles that pass by the filter member and impart a predetermined flow pattern to the particles.

27. The device of claim 23, wherein the aerosolization assembly comprises a liquid supply member comprising a liquid feed channel, the feed channel having an inlet in communication with the reservoir, an liquid supply member exit orifice, and a supply member end-wall face having an outside diameter disposed about the liquid supply member exit orifice, the liquid supply member feed channel defining a projected axis L,

wherein the assembly further comprises a compressed fluid supply member comprising a compressed fluid channel having an exit orifice,

wherein the end wall face and liquid feed channel exit orifice are separated by a distance of at least H from compressed fluid channel exit orifice, H being measured along a projected axis F that is normal to a plane P defined by the compressed fluid channel exit orifice,

H is equal to or greater than ¼

, ½

or 1×

the inner diameter D1 of the compressed fluid channel adjacent the compressed fluid channel exit orifice,

the projected longitudinal axis L intersects the projected axis F at a right, acute or obtuse angle, defining an intersection plane I, and wherein

at the distance H along projected axis F, the plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected axis F, S being equal to or less than 2×

the inner diameter D1 of the primary compressed fluid channel.

28. The device of claim 23, wherein the liquid for which the reservoir is configured to hold comprises at least one selected from the group consisting of medicaments, small or large molecule pharmaceutical agents, liquids, solutions, suspensions, emulsions, perfumes, fragrances, essential oils, cosmeceutical agents, oils, cosmeceutical agents, moisturizing agents, water, lotions, air fresheners, deionizing agents, aromatherapeutic agents, beverages, and skin treatments.

29. The device of claim 23, further comprising a nasal, ocular, oral or ‘

vicinity’

adapter in communication with the atomization means.

30. An aerosol generating and delivery device, comprising:

a housing having a wall defining an atomization chamber in which a liquid or solution is atomizable, and comprising holding means suitable for holding a liquid or solution to be atomized; and

atomization means comprising a primary compressed fluid feed channel having a length and inner diameter, and a primary orifice at a first end thereof in fluid communication with the atomization chamber and defining a primary orifice plane P, the channel at a second end in fluid communication with a compressed fluid source and defining a projectable compressed fluid feed channel axis F, the atomization means further comprising a primary liquid feed channel having a length, inner diameter and channel wall, and at a first channel end having a channel end-wall face having an outside diameter disposed about a liquid feed channel orifice in fluid communication with the atomization chamber, the primary liquid feed channel at a second end in communication with the liquid holding means, the primary liquid feed channel defining a projectable longitudinal liquid feed channel axis L, wherein

the channel end wall face and the liquid feed channel orifice are separated by a distance of at least H from the primary orifice plane P, H being measured along the projected axis F and H being equal to or greater than ¼

, ½

or 1×

the inner diameter D1 of the primary compressed fluid feed channel, wherein

the projected longitudinal axis L intersects the projected longitudinal axis F at a right, acute or obtuse angle, defining an intersection plane I, and wherein

at the distance H along projected longitudinal axis F, the plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected longitudinal axis F, S being equal to or less than 2×

the inner diameter D1 of the primary compressed fluid feed channel.

31. The aerosol generating and delivery device of claim 30, further comprising a particle filter member in fluid communication with the particle atomization means, the particle filter member having a surface contour and positioned at a distance of at least J along the projected axis F from the primary orifice plane P to provide an aerodynamic fluid flow around the surface, and wherein the distance J is greater than the distance H.

32. The aerosol generating and delivery device of claim 31, wherein the distance J along the projected axis F from the primary orifice plane P is equal to or greater than 2×

D1, 3×

D1, 5×

D1, 10×

D1, 15×

D1, 20×

D1, 30×

D1, 40×

D1 or 50×

D1.

33. The aerosol generating and delivery device of claim 31, wherein the configuration and positioning of the filter member along the projected axis F operationally provides, depending on particle size and/or mass, for a proportion of atomized particles that collide with the member and a proportion of non-colliding particles with velocity vectors that avoid the surface and/or are carried in the aerodynamic fluid flow around the surface.

34. The aerosol generating and delivery device of claim 31, wherein the particle filter member is held at the distance J along the projected axis F by at least one filter support member communicating with the wall of the atomization chamber, the support member configured to operatively direct liquid accumulating on the filter away from the filter member for return to the liquid holding means.

35. The aerosol generating and delivery device of claim 30, further comprising a secondary liquid feed channel having a length and an inner diameter D4, and communicating between the second end of the primary liquid feed channel and the liquid holding means, wherein the inner diameter D4 is larger than the inner diameter D2 of the primary liquid feed channel.

36. The aerosol generating and delivery device of claim 35, wherein D4 is equal to or greater than 2×

D2, 3×

D2, 5×

D2, 10×

D2, 15×

D2, 20×

D2, 30×

D2, 40×

D2 or 50×

D2.

37. The aerosol generating and delivery device of claim 35, wherein D4 is from about 1 mm to about 5 mm, from about 1.5 mm to about 3 mm, or from about 2 mm to about 2.5 mm.

38. The aerosol generating and delivery device of claim 30, wherein the distance S from projected axis F is less than or equal to ½

×

D1.

39. The aerosol generating and delivery device of claim 30, wherein the selected distance S is such that there is overlap of axis F with the plane I-intersecting portion of the perimeter of the end wall face, wherein overlap is defined as being present if the projected axis F intersects the end wall face or the liquid feed channel orifice thereof.

40. The aerosol generating and delivery device of claim 39, wherein the distance S from projected axis F is less than or equal to ½

×

D1.

41. The aerosol generating and delivery device of claim 30, wherein H is less than, equal to, or greater than D1.

42. The aerosol generating and delivery device of claim 41, wherein H is equal to or greater than D1.

43. The aerosol generating and delivery device of claim 30, wherein H is less than, equal to, or greater than D2.

44. The aerosol generating and delivery device of claim 43, wherein H is equal to or greater than D2.

45. The aerosol generating and delivery device of claim 30, wherein H is less than, equal to, or greater than D3.

46. The aerosol generating and delivery device of claim 45, wherein H is less than D3.

47. The aerosol generating and delivery device of claim 30, wherein H is less than D3, and greater than D1, H is less than D3, and greater than D2, or H is less than D3, and greater than either D1 or D2.

48. The aerosol generating and delivery device of claim 30, wherein H is greater than any one of D1, D2 or D3.

49. The aerosol generating and delivery device of claim 30, wherein D2 is equal to or greater than D1.

50. The aerosol generating and delivery device of claim 30, further comprising a particle dispersion chamber having a chamber wall and having an input opening and an output opening with an internal channel therebetween, the input opening in fluid communication with the atomization chamber, the dispersion chamber having at least one directed fluid output operative to impart a fluid flow pattern to aerosolized particles within and exiting the dispersion chamber output opening.

51. The aerosol generating and delivery device of claim 50, wherein the imparted fluid flow pattern is vortical flow, turbulent flow or randomized flow.

52. The aerosol generating and delivery device of claim 50, wherein the at least one directed fluid output comprises an ambient air channel that at one end is in communication with ambient air, and having at the other end an ambient air channel orifice in communication with the internal channel.

53. The aerosol generating and delivery device of claim 52, further comprising an outer housing having an outer housing wall defining a plenum space between the outer housing wall and the wall of the particle dispersion chamber, the outer housing wall comprising at least one opening in communication with ambient air, such that the ambient air channel and corresponding orifice communicate with the at least one opening by means of the plenum space.

54. The aerosol generating and delivery device of claim 53, further comprising a one-way valve in operative association with the at least one opening of the outer housing wall.

55. The aerosol generating and delivery device of claim 50 wherein the at least one directed fluid output comprises a compressed fluid output channel that at one end is in communication with a source of compressed fluid, and having at the other end a compressed fluid outlet orifice in communication with the internal channel of the particle dispersion chamber.

56. The aerosol generating and delivery device of claim 55, additionally comprising:

a secondary compressed fluid channel intermediate between the primary compressed fluid feed channel and a source of compressed fluid; and

a particle dispersion chamber feed channel communicating between the secondary compressed fluid channel and the at least one directed compressed fluid outlets and corresponding orifices.

57. The aerosol generating and delivery device of claim 50, comprising a plurality of directed fluid outputs, the plurality comprising at least one ambient air channel that at one end is in communication with ambient air, and having at the other end an ambient air channel orifice in communication with the internal channel of the particle dispersion chamber, the plurality further comprising at least one compressed fluid output channel that at one end is in communication with a source of compressed fluid, and having at the other end a compressed fluid outlet orifice in communication with the internal channel of the particle dispersion chamber.

58. The aerosol generating and delivery device of claim 57, further comprising an outer housing having an outer housing wall defining a plenum space between said outer housing wall and the wall of the particle dispersion chamber, the outer housing wall comprising at least one opening in communication with ambient air, such that the ambient air channel and corresponding orifice communicate with the at least one opening by means of the plenum space.

59. The aerosol generating and delivery device of claim 58, further comprising a one-way valve in operative association with the at least one opening of the outer housing wall

60. The aerosol generating and delivery device of claim 50, additionally comprising:

a secondary compressed fluid channel intermediate between the primary compressed fluid feed channel and a source of compressed fluid; and

a particle dispersion chamber feed channel communicating between the secondary compressed fluid channel and the at least one directed compressed fluid outlets and corresponding orifices.

61. The aerosol generating and delivery device of claim 50, further comprising a nasal adapter in fluid communication with the output opening of the particle dispersion chamber.

62. The aerosol generating and delivery device of claim 61, wherein the nasal adapter comprises at least one oriented opening, configured to channel particles into a sub-region of the nasal apertures to more selectively target particle delivery within the nasal cavity, and regions thereof, of a user.

63. The aerosol generating and delivery device of claim 50, further comprising an ocular adapter in fluid communication with the output opening of the particle dispersion chamber.

64. An aerosol generating and delivery device, comprising:

a housing having a wall defining an atomization chamber in which a liquid or solution is atomizable, and comprising holding means suitable for holding a liquid or solution to be atomized;

atomization means comprising a primary compressed fluid feed channel having a length and inner diameter, and a primary orifice at a first end thereof in fluid communication with the atomization chamber and defining a primary orifice plane P, the channel at a second end in fluid communication with a compressed fluid source and defining a projectable compressed fluid feed channel axis F, the atomization means further comprising a primary liquid feed channel having a length, inner diameter and channel wall, and at a first channel end having a channel end-wall face having an outside diameter disposed about a liquid feed channel orifice in fluid communication with the atomization chamber, the primary liquid feed channel at a second end in communication with the liquid holding means, the primary liquid feed channel defining a projectable longitudinal liquid feed channel axis L; and

a particle filter member in fluid communication with the particle atomization means, the filter member positioned at a distance J, greater than or equal to 10×

the inner diameter D1 of the primary compressed fluid feed channel, along the projected axis F from the primary orifice plane P, wherein

the projected longitudinal axis L intersects the projected longitudinal axis F at an acute or obtuse angle, defining an intersection plane I, wherein

the channel end wall face and the liquid feed channel orifice are separated by a distance of at least H from the primary orifice plane P, H being measured along the projected axis F and H being equal to or greater than ¼

×

D1, and wherein

at the distance H along projected longitudinal axis F, a plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected longitudinal axis F, S being equal to or less than 2×

D1.

65. The aerosol generating and delivery device of claim 64, wherein the projected longitudinal axis L intersects the projected longitudinal axis F at an acute angle.

66. The aerosol generating and delivery device of claim 64, further comprising a particle dispersion chamber having a chamber wall and having an input opening and an output opening with an internal channel therebetween, the input opening in fluid communication with the atomization chamber, the dispersion chamber having at least one directed fluid output operative to impart a fluid flow pattern to aerosolized particles within and exiting the dispersion chamber output opening.

67. An aerosol generating and delivery device, comprising:

a housing having a wall defining an atomization chamber in which a liquid or solution is atomizable, and comprising holding means suitable for holding a liquid or solution to be atomized;

atomization means comprising a primary compressed fluid feed channel having a length and inner diameter, and a primary orifice at a first end thereof in fluid communication with the atomization chamber and defining a primary orifice plane P, the channel at a second end in fluid communication with a compressed fluid source and defining a projectable compressed fluid feed channel axis F, the atomization means further comprising a primary liquid feed channel having a length, inner diameter and channel wall, and at a first channel end having a channel end-wall face having an outside diameter disposed about a liquid feed channel orifice in fluid communication with the atomization chamber, the primary liquid feed channel at a second end in communication with the liquid holding means, the primary liquid feed channel defining a projectable longitudinal liquid feed channel axis L; and

a secondary liquid feed channel having a length and an inner diameter D4, and communicating between the second end of the primary liquid feed channel and the liquid holding means, wherein the inner diameter D4 is equal to or greater than 5×

the inner diameter D2 of the primary liquid feed channel, wherein

the projected longitudinal axis L intersects the projected longitudinal axis F at an acute or obtuse angle, defining an intersection plane I, wherein

the channel end wall face and the liquid feed channel orifice are separated by a distance of at least H from the primary orifice plane P, H being measured along the projected axis F and H being equal to or greater than ¼

×

D1, and wherein

at the distance H along projected longitudinal axis F, a plane I-intersecting portion of the perimeter of the end-wall face is positioned at a distance S in a normal direction from the projected longitudinal axis F, S being equal to or less than 2×

the inner diameter D1 of the primary compressed fluid feed channel.

68. The aerosol generating and delivery device of claim 67, wherein the projected longitudinal axis L intersects the projected longitudinal axis F at an acute angle.

69. The aerosol generating and delivery device of claim 67, further comprising a particle dispersion chamber having a chamber wall and having an input opening and an output opening with an internal channel therebetween, the input opening in fluid communication with the atomization chamber, the dispersion chamber having at least one directed fluid output operative to impart a fluid flow pattern to aerosolized particles within and exiting the dispersion chamber output opening.

70. A particle filter assembly configured to be positioned within a stream of aerosolized particles comprising a first group of aerosolized particles having a size greater than a predetermined size and a second group having a size less than or equal to the predetermined size, the particle filter assembly comprising:

a filtering member configured aerodynamically to collect the aerosolized particles of the first group and to avoid collisions with the aerosolized particles of the second group permitting the aerosolized particles of the second group to pass thereby; and

a support member configured to support the filtering member within the stream of aerosolized particles and to conduct the aerosolized particles of the first group collected by the filtering member to a reservoir.

71. The particle filter assembly of claim 70, wherein the support member is configured aerodynamically to avoid collisions with the aerosolized particles of the stream of aerosolized particles.

72. The particle filter assembly of claim 70, wherein the stream of aerosolized particles is produced inside an atomization chamber defined by at least one chamber wall and the support member comprises at least one support arm coupling the filtering member to the at least one chamber wall.

73. The particle filter assembly of claim 70, wherein the stream of aerosolized particles is produced inside an atomization chamber and emanates therefrom and the support member positions the filtering member outside the atomization chamber within a portion of the stream outside the atomization chamber.

74. The particle filter assembly of claim 70, wherein the stream of aerosolized particles is produced inside an atomization chamber having an exit aperture through which the stream may exit the atomization chamber and the support member positions the filtering member within the exit aperture of the atomization chamber.

75. The particle filter assembly of claim 70, wherein the stream of aerosolized particles emanate from an aerosolization assembly comprising a liquid supply member comprising a liquid feed channel, the feed channel having an inlet in communication with the reservoir, an liquid supply member exit orifice, and a supply member end-wall face having an outside diameter disposed about the liquid supply member exit orifice, the liquid supply member feed channel defining a projected axis L,

wherein the assembly further comprises a compressed fluid supply member comprising a compressed fluid channel having an exit orifice,

wherein the end wall face liquid feed channel exit orifice are separated by a distance of at least H from compressed fluid channel exit orifice, H being measured along a projected axis F that is normal to a plane P defined by the compressed fluid channel exit orifice,

H is equal to or greater than ¼

, ½

or 1×

the inner diameter D1 of the compressed fluid channel adjacent the compressed fluid channel exit orifice, and

Wherein the support member is configured to support the filtering member within the stream of aerosolized particles at a distance J from the compressed fluid channel exit orifice, J being measured along the projected axis F, and wherein the distance J is greater than the distance H.

76. A method of generating aerosol particles comprising:

directing a stream of compressed fluid into an atomization chamber;

placing a liquid feed member comprising a liquid in the stream of compressed fluid thereby disrupting a portion of the stream of compressed fluid; and

using the disrupted portion of the stream of compressed fluid to atomize the liquid in the liquid feed member.

77. The method of claim 76, comprising filtering particles larger than a predetermined size from the atomized liquid.

78. The method of claim 76, further comprising imparting a predetermined particle flow pattern to the atomized liquid.

79. The method of claim 76, wherein the liquid comprises at least one selected from the group consisting of medicaments, small or large molecule pharmaceutical agents, liquids, solutions, suspensions, emulsions, perfumes, fragrances, essential oils, cosmeceutical agents, oils, cosmeceutical agents, moisturizing agents, water, lotions, air fresheners, deionizing agents, aromatherapeutic agents, beverages, and skin treatments.

80. The method of claim 76, further comprising use of a nasal, ocular, oral or ‘

vicinity’

adapter in communication with the atomization means.

81. The device of claim 76, further comprising imparting a predetermined particle flow pattern to the atomized liquid and directing the atomized liquid into at least one of a nostril of a user, both nostrils of a user, a mouth of a user, at least one of an eye of a user, and both eyes of a user.

82. The device of claim 76, further comprising expelling the atomized liquid into the ambient air thereby creating a cloud of atomized liquid.

83. A method of nasal delivery of aerosolized particles, comprising:

obtaining a subject inspiring through the nose;

delivering, over a plurality of nasal inspirations, aerosolized particles of a liquid formulation into at least one nasal passage of the subject, wherein a volume in the range of 0.2 to 2.0 ml, 0.4 to 1.5 ml, 0.6 to 1.2 ml, 0.8 to 1.1 ml, or 0.9 to 1 ml is delivered, wherein the number of inspirations is from about 8 to about 16, and wherein at least about 30%, about 50%, about 60%, about 70%, about 80% about 90% or about 100% of the delivered volume is retained in the at least one nasal passage.

84. The method of claim 83, wherein the average tidal volume (V_t) is about 0.7 ml/Kg.

85. The method of claim 83, wherein a volume in the range of about 0.4 to 1.5 ml, 0.6 to 1.2 ml, 0.8 to 1.1 ml, or 0.9 to 1 ml is delivered.