Methods and systems for modulating acoustic energy delivery

• US 20080056960A1
• Filed: 08/20/2007
• Published: 03/06/2008
• Est. Priority Date: 10/28/1998
• Status: Active Grant

• Current Assignee: Covaris, Inc.
• Original Assignee: Covaris, Inc.
• Inventors: McKnight, Robert, Laugharn, James, Yates, Douglas, Garrison, Brevard
• Granted Patent: US 8,263,005 B2
• Time in Patent Office: Days
• US Class Current: 422/127
• CPC Class Codes: B01F 2215/0427 Numerical distance values, e.g. separation, position
• CPC Class Codes: B01F 2215/0431 Numerical size values, e.g. diameter of a hole or conduit, area, volume, length, width, or ratios thereof
• CPC Class Codes: B01F 2215/045 Numerical flow-rate values
• CPC Class Codes: B01F 2215/0454 Numerical frequency values
• CPC Class Codes: B01F 2215/0468 Numerical pressure values
• CPC Class Codes: B01F 2215/0477 Numerical time values
• CPC Class Codes: B01F 31/80 Mixing by means of high-frequency vibrations above one kHz, e.g. ultrasonic vibrations
• CPC Class Codes: B01F 31/87 transmitting the vibratory energy by means of a fluid, e.g. by means of air shock waves
• CPC Class Codes: B01F 33/30 Micromixers
• CPC Class Codes: B01F 33/403 for mixing liquids B01F33/402, B01F33/405, B01F33/406 take precedence
• CPC Class Codes: B01F 33/408 Controlling
• CPC Class Codes: B01F 35/2115 Temperature
• CPC Class Codes: B01F 35/2202 Controlling the mixing process by feed-back, i.e. a measured parameter of the mixture is measured, compared with the set-value and the feed values are corrected
• CPC Class Codes: B01J 19/0046 Sequential or parallel reactions, e.g. for the synthesis of polypeptides or polynucleotides; Apparatus and devices for combinatorial chemistry or for making molecular arrays synthesis methods per se C40B50/00
• CPC Class Codes: B01J 19/008 Processes for carrying out reactions under cavitation conditions
• CPC Class Codes: B01J 19/0093 Microreactors, e.g. miniaturised or microfabricated reactors laboratory containers with capillary fluid transport in microfabricated channels or chambers B01L3/5027
• CPC Class Codes: B01J 19/10 employing sonic or ultrasonic vibrations
• CPC Class Codes: B01J 2219/00308 interchangeably mounted in racks or blocks
• CPC Class Codes: B01J 2219/00315 Microtiter plates
• CPC Class Codes: B01J 2219/00317 Microwell devices, i.e. having large numbers of wells
• CPC Class Codes: B01J 2219/00486 : by sonication or ultrasonication
• CPC Class Codes: B01J 2219/00495 : Means for heating or cooling the reaction vessels
• CPC Class Codes: B01J 2219/00659 : Two-dimensional arrays
• CPC Class Codes: B01J 2219/00722 : Nucleotides
• CPC Class Codes: B01J 2219/00783 : Laminate assemblies, i.e. the reactor comprising a stack of plates
• CPC Class Codes: B01J 2219/00889 : Mixing
• CPC Class Codes: B01L 2400/0436 : acoustic forces, e.g. surface acoustic waves [SAW]
• CPC Class Codes: B01L 3/50273 : characterised by the means or forces applied to move the fluids micropumps F04B19/006, of the membrane type F04B43/043
• CPC Class Codes: B01L 3/5085 : for multiple samples, e.g. microtitration plates
• CPC Class Codes: C40B 60/14 : for creating libraries
• CPC Class Codes: G01N 2035/00554 : using ultrasound
• CPC Class Codes: G01N 2291/02836 : Flow rate, liquid level
• CPC Class Codes: G01N 2291/02872 : Pressure
• CPC Class Codes: G01N 2291/02881 : Temperature

Abstract

The present invention provides systems, methods, and devices for using acoustic energy.

Claims

1-31. -31. (canceled)

32. An apparatus for treating one or more samples using acoustic energy, the apparatus comprising:

an acoustic energy source for providing a focused acoustic field having a frequency of between about 100 kilohertz and about 100 megahertz;

a medium for coupling the acoustic field to the one or more samples;

a reaction vessel for holding the one or more samples;

a processor for receiving information on a presence of a solid in the one or more samples and for controlling at least one of the acoustic energy source and the location of the vessel relative to the acoustic field based, at least in part, on the information.