BISPECIFIC ANTIBODIES AND AGENTS TO ENHANCE STEM CELL HOMING
First Claim
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1. A composition, comprising:
- a bispecific antibody which binds a stem cell specific antigen and a tissue, differentiated cell or condition associated antigen; and
an agent that enhances expression of the tissue, differentiated cell or condition associated antigen.
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Abstract
A composition having a bispecific antibody which binds a stem cell specific antigen and a tissue, differentiated cell or condition associated antigen and an agent that enhances expression of the tissue, differentiated cell or condition associated antigen, is provided. Also provided are methods of using the bispecific antibodies and/or agents to enhance cell therapy.
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Citations
39 Claims
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1. A composition, comprising:
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a bispecific antibody which binds a stem cell specific antigen and a tissue, differentiated cell or condition associated antigen; and an agent that enhances expression of the tissue, differentiated cell or condition associated antigen. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16)
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17. A method of enhancing localization and retention of stem cells, comprising:
delivering to a mammal in need of cell therapy an effective amount of bispecific antibodies which bind a stem cell specific antigen and a tissue, differentiated cell or condition associated antigen, an agent or treatment that enhances expression of the tissue, differentiated cell or condition associated antigen, and donor stem cells. - View Dependent Claims (18, 19, 20, 21, 22, 23, 24, 25, 26, 28, 29)
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27. A method for targeting stem cells to a site of injury or inflammation, comprising:
- delivering to a mammal an effective amount of bispecific antibodies which bind a stem cell specific antigen and an antigen associated with injury or inflammation, an agent or treatment that enhances expression of the injury or inflammation associated antigen, and donor stem cells having the stem cell specific antigen, wherein the agent is locally delivered.
- 30. A method for targeting stem cells to a selected location in a mammal, comprising delivering to a mammal in need of cell therapy an effective amount of bispecific antibodies which bind a stem cell specific antigen and a tissue or differentiated cell specific antigen, and donor stem cells, wherein the tissue or differentiated cell specific antigen is specific for neuronal cells, microglial cells, pancreatic cells, cartilage, or endothelial cells.
- 36. A composition comprising a bispecific antibody which binds a stem cell specific antigen and a tissue, differentiated cell or condition associated antigen, which antibody is linked to a protein or drug that enhances cell engraftment, enhances cell extravasation, enhances angiogenesis, or inhibits apoptosis.
Specification