MEDICAL DEVICES FOR CONTROLLED DRUG RELEASE
First Claim
1. A medical device for controlling the release of an active agent, the medical device comprising:
- a supporting structure configured and dimensioned to be used within a body of an animal;
a porous body disposed on and at least partially covering the supporting structure, said porous body including a first biocompatible material having a plurality of pores;
a therapeutically effective amount of an active agent disposed within at least a portion of the pores; and
an elution rate controlling matrix disposed on at least one surface of the porous body so as to contain the active agent within said at least a portion of the pores, said matrix including a second biocompatible material that controls an elution rate of the active agent from the pores.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention is a medical device for controlling the release of an active agent. The medical device has a supporting structure having a porous body disposed therein. At least one elution rate controlling matrix containing an effective amount of at least one active agent is disposed within the pores of the porous body in a manner that protects the matrix from mechanical damage. The medical device may therefore be used for controlled drug release applications. Additionally, the present invention discloses a method for using the medical device for the treatment and prevention of diseases in mammals. This invention further relates to a method for using the medical device for treating and preventing vascular diseases.
-
Citations
30 Claims
-
1. A medical device for controlling the release of an active agent, the medical device comprising:
-
a supporting structure configured and dimensioned to be used within a body of an animal;
a porous body disposed on and at least partially covering the supporting structure, said porous body including a first biocompatible material having a plurality of pores;
a therapeutically effective amount of an active agent disposed within at least a portion of the pores; and
an elution rate controlling matrix disposed on at least one surface of the porous body so as to contain the active agent within said at least a portion of the pores, said matrix including a second biocompatible material that controls an elution rate of the active agent from the pores. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
-
-
11. A medical device for controlling the release of an active agent, the medical device comprising:
-
a supporting structure configured and dimensioned to be used within a body of a human;
a porous body disposed on and at least partially covering the supporting structure, said porous body including a first biocompatible material having a plurality of pores;
a therapeutically effective amount of an active agent disposed within said pores;
an elution rate controlling matrix disposed within the porous body so as to contain said active agent within said pores, said matrix including a polymeric biocompatible material that at least partially determines an elution rate of the active agent from the pores; and
said pores each having a dimension that is configured to at least partially determine said elution rate. - View Dependent Claims (12, 13, 14, 15, 16, 17, 18, 19, 20)
-
-
21. A drug eluting stent for controlling the release of an active agent, the stent comprising:
-
an expandable supporting structure configured and dimensioned as a stent to be used within a lumen of an animal, said expandable supporting structure having a delivery orientation and a deployed orientation;
a porous body disposed on and at least partially covering the supporting structure, said porous body including a first biocompatible material having a plurality of pores;
a therapeutically effective amount of an active agent disposed within at least a portion of the pores; and
an elution rate controlling matrix disposed on at least one surface of the porous body so as to contain the active agent within said at least a portion of the pores, said matrix including a second biocompatible material that determines an elution rate of the active agent from the pores. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30)
-
Specification