METHODS OF MANUFACTURING MEDICAL DEVICES FOR CONTROLLED DRUG RELEASE
First Claim
1. A method of manufacturing a medical device used for treating and/or preventing a disease in an animal by controlling the release of an active agent, the method comprising:
- fabricating a supporting structure;
fabricating a porous body onto at least a portion of the supporting structure, said porous body including a first biocompatible material having a plurality of pores;
introducing a therapeutically effective amount of an active agent into at least a portion of the pores; and
introducing an elution rate controlling matrix onto at least one surface of the porous body so as to contain the active agent within said at least a portion of the pores, said matrix including a second biocompatible material that controls the elution of the active agent from the pores.
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Accused Products
Abstract
The present invention is a medical device for controlling the release of an active agent. The medical device has a supporting structure having a porous body disposed therein. At least one elution rate controlling matrix containing an effective amount of at least one active agent is disposed within the pores of the porous body in a manner that protects the matrix from mechanical damage. The medical device may therefore be used for controlled drug release applications. Additionally, the present invention discloses a method for using the medical device for the treatment and prevention of diseases in mammals. This invention further relates to a method for using the medical device for treating and preventing vascular diseases.
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Citations
27 Claims
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1. A method of manufacturing a medical device used for treating and/or preventing a disease in an animal by controlling the release of an active agent, the method comprising:
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fabricating a supporting structure;
fabricating a porous body onto at least a portion of the supporting structure, said porous body including a first biocompatible material having a plurality of pores;
introducing a therapeutically effective amount of an active agent into at least a portion of the pores; and
introducing an elution rate controlling matrix onto at least one surface of the porous body so as to contain the active agent within said at least a portion of the pores, said matrix including a second biocompatible material that controls the elution of the active agent from the pores. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of manufacturing a drug eluting endoprosthesis used for treating and/or preventing a disease in an animal by controlling the release of an active agent, the method comprising:
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fabricating a supporting structure;
fabricating a porous body onto at least a portion of the supporting structure, said porous body including a first biocompatible material having a plurality of pores;
introducing a therapeutically effective amount of an active agent into at least a portion of the pores; and
introducing an elution rate controlling matrix onto at least one surface of the porous body so as to contain the active agent within said at least a portion of the pores, said matrix material including a second biocompatible material that controls the elution of the active agent from the pores, wherein said elution rate controlling matrix is disposed within the pores such that substantially none of the matrix protrudes from the pores and the porous body protects the matrix. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27)
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Specification