Compositions and methods for treating disease utilizing a combination of radioactive therapy and cell-cycle inhibitors

• US 20080058579A1
• Filed: 11/06/2006
• Published: 03/06/2008
• Est. Priority Date: 11/12/1999
• Status: Abandoned Application

• Current Assignee: Angiotech Pharmaceuticals Incorporated
• Original Assignee: Angiotech Pharmaceuticals Incorporated
• Inventors: Loss, Troy, Liggins, Richard, Gravett, David, Hunter, William, Maiti, Arpita, Toleikis, Philip
• Application Number:
  US11/594,022
• Publication Number:
  US 20080058579A1
• Time in Patent Office: Days
• US Class Current: 600/8
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 41/0038 Radiosensitizing, i.e. administration of pharmaceutical agents that enhance the effect of radiotherapy radiotherapy per se A61N5/10
• CPC Class Codes: A61K 49/0002 General or multifunctional contrast agents, e.g. chelated agents
• CPC Class Codes: A61K 49/222 characterised by a special physical form, e.g. emulsions, liposomes
• CPC Class Codes: A61K 51/1282 Devices used in vivo and carrying the radioactive therapeutic or diagnostic agent, therapeutic or in vivo diagnostic kits, stents
• CPC Class Codes: A61L 31/18 Materials at least partially X-ray or laser opaque
• CPC Class Codes: A61N 2005/1019 Sources therefor
• CPC Class Codes: A61N 2005/1023 Means for creating a row of seeds, e.g. spacers
• CPC Class Codes: A61N 5/1027 Interstitial radiation therapy

Abstract

Disclosed herein are therapeutic devices, compositions and methods for treating proliferative diseases. For example, within one aspect of the invention therapeutic devices are provided, comprising a device that locally administers radiation and a cell-cycle inhibitor

Claims

1. A therapeutic device, comprising a device which locally administers radiation, and a cell-cycle inhibitor.

2. The device according to claim 1 wherein said device is a radioactive stent.

3. The device according to claim 1 wherein said device is a radioactive rod.

4. The device according to claim 1 wherein said device is a radioactive disk.

5. The device according to claim 1 wherein said device is a radioactive seed.

6. The device according to claim 1 wherein said device is a radioactive suture.

7. The device according to claim 1 wherein said device further comprises a polymer.

8. The device according to claim 7 wherein said cell-cycle inhibitor is released by said polymer.

9. The device according to claim 1 wherein said radiation is released from a polymer.

10. The device according to claim 7 wherein said polymer is a non-biodegradable polymer.

11. The device according to claim 7 wherein said polymer is a biodegradable polymer.

12. The device according to claim 7 wherein said polymer is echogenic or radiopaque.

13. The device according to claim 1, wherein said device is echogenic or radiopague.

14. A therapeutic device, comprising:

a radioactive source sized to be positioned into the tissue of a patient adjacent to a site to be treated by locally administered radiation from the radioactive source; and

a cell-cycle inhibitor positioned adjacent to the radioactive source.

18. The device according to claim 14 wherein said device is echogenic or radiopaque.

15-17. -17. (canceled)

19. (canceled)

20. A method for treating a hyperproliferative disease of the prostate, comprising administering to the prostate a cell cycle inhibitor and a radioactive source, such that said hyperproliferative disease of the prostate is treated.

33. The method according to claim 20 wherein said cell-cycle inhibitor or radioactive source is echogenic or radiopaque.

34. The method according to claim 20 wherein said cell-cycle inhibitor or radioactive source further comprise an echogenic or radiopaque coating.

21-32. -32. (canceled)

35-37. -37. (canceled)