Silicon microprobe with integrated biosensor

• US 20080058624A1
• Filed: 10/30/2007
• Published: 03/06/2008
• Est. Priority Date: 03/26/2001
• Status: Abandoned Application

• Current Assignee: Eugene Orloff, Kumar Subramanian, Wilson Smart
• Original Assignee: Eugene Orloff, Kumar Subramanian, Wilson Smart
• Inventors: Subramanian, Kumar, Smart, Wilson, Orloff, Eugene
• Application Number:
  US11/980,853
• Publication Number:
  US 20080058624A1
• Time in Patent Office: Days
• US Class Current: 600/345
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 5/0002 Remote monitoring of patients using telemetry, e.g. transmission of vital signals via a communication network A61B5/07 takes precedence; transmission systems for measured values G08C; transmission H04B; transmission of digital information H04L; wireless communication networks H04W
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/14546 for measuring analytes not otherwise provided for, e.g. ions, cytochromes
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/685 Microneedles

Abstract

Microprobe device 10 provides an analyte signal from biosensor 12 to an external analyte meter indicating analyte presence in an analyte-containing bodily fluid of a subject (not shown).

Claims

1. A microprobe device to provide a signal to an analyte meter indicating analyte presence in an analyte-containing bodily fluid of a subject comprising:

a single substrate having a body portion and a microprobe portion, the body portion and microprobe portion integrally formed together on the substrate;

an open fluid channel formed in the substrate, the channel positioned longitudinally along a surface of the substrate from a penetration end of the microprobe portion to the body portion of the substrate;

a cavity extending into the body portion of the substrate; and

a biosensor integrated with a surface of the substrate, the biosensor located over the cavity and configured to sense the analyte presence and provide a signal in response thereto.

2. The device of claim 1, wherein a portion of the fluid channel that passes into the subject during penetration is uncovered.

3. The device of claim 2, wherein the open fluid channel is configured to transport the analyte-containing fluid to the biosensor by capillary action even in the absence of a cover over any portion of the fluid channel that passes into the subject during penetration.

4. The device of claim 5, wherein the cavity is in fluid contact with the open fluid channel.

5. The device of claim 3, wherein the open fluid channel has a cross-section of any shape etched into the substrate of the microprobe portion.

6. The device of claim 4, wherein the cavity has at least one cross-sectional dimension that is greater than that of the channel.

7. The device of claim 1, wherein the biosensor is coupled with the cavity, the cavity located in at least part of the open fluid channel.

8. The device of claim 7, wherein the biosensor is located in the cavity.

9. The device of claim 1, wherein the substrate is a silicon substrate.

10. A microprobe device to provide a signal to an analyte meter indicating analyte presence in an analyte-containing bodily fluid of a subject comprising:

a single substrate having a body portion and a microprobe portion, the body portion and microprobe portion integrally formed together on the substrate;

a biosensor integrated with the substrate, the biosensor located on the body portion of the microprobe and configured to sense the analyte presence and provide a signal in response thereto; and

an open fluid channel formed in the substrate, the channel positioned longitudinally along a surface of the substrate from a penetration end of the microprobe portion to the body portion of the substrate.

11. The device of claim 10, wherein a portion of the fluid channel that passes into the subject during penetration is uncovered.

12. The device of claim 11, wherein the open fluid channel is to transport the analyte-containing fluid to the biosensor by capillary action even in the absence of a cover over any portion of the fluid channel that passes into the subject during penetration.

13. The device of claim 12, wherein the biosensor is uncovered.

14. The device of claim 10, further comprising a cavity extending into the substrate, the cavity located in at least part of the open fluid channel.

15. The device of claim 14, wherein the cavity is in fluid contact with the open fluid channel.

16. The device of claim 15, wherein the biosensor is coupled with the cavity.

17. The device of claim 10, wherein the biosensor is positioned over the open fluid channel.

18. The device of claim 10, wherein the substrate is a silicon substrate.

19. The device of claim 10, wherein the microprobe portion is width tapered along an entire length dimension, wherein the rate of decrease in width at a penetration end of the microprobe portion of the substrate is greater than the rate of decrease in width at a body end of the microprobe portion of the substrate.

20. The device of claim 19, wherein the surface is a planar surface.

21. A microprobe device to provide a signal to an analyte meter indicating analyte presence in an analyte-containing bodily fluid of a subject comprising:

a single silicon substrate having a body portion and a microprobe portion, the body portion and microprobe portion integrally formed together on the substrate;

an open fluid channel formed in the substrate, the channel positioned longitudinally along a surface of the substrate from a penetration end of the microprobe portion to the body portion of the substrate;

a cavity extending into the body portion of the substrate; and

a biosensor integrated with a surface of the substrate, the biosensor located over the cavity and configured to sense the analyte presence and provide a signal in response thereto.

22. The device of claim 21, wherein a portion of the fluid channel that passes into the subject during penetration is uncovered.

23. The device of claim 22, wherein the open fluid channel is configured to transport the analyte-containing fluid to the biosensor by capillary action even in the absence of a cover over any portion of the fluid channel that passes into the subject during penetration.

24. The device of claim 23, wherein the cavity is in fluid contact with the open fluid channel.

25. The device of claim 24, wherein the open fluid channel has a cross-section of any shape etched into the substrate of the microprobe portion.