Methods and Apparatus Incorporating a Surface Penetration Device
First Claim
1. A surface penetration device comprising:
- a substrate comprising an upper surface and a backside;
a tapered elongate structure extending from and supported by the substrate upper surface, the elongate structure comprising a distal portion, a proximal portion supported at the substrate upper surface, a lumen, wherein a cross section of the lumen is asymmetrical and comprises a first defining dimension that is larger than a second defining dimension, and a plurality of lumen openings, wherein the lumen extends from the lumen openings and through the elongate structure, and wherein at least one lumen opening comprises an elongate geometry and is positioned proximal to the elongate structure'"'"'s distal portion.
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Accused Products
Abstract
A surface penetration device, methods of use and methods of manufacture thereof are provided. The device includes a substrate supporting a tapered elongate structure extending from and supported by the substrate upper surface. The elongate structure includes a distal portion, a proximal portion supported at the substrate upper surface, a lumen, and a plurality of lumen openings. A cross section of the lumen is asymmetrical and includes a fist defining dimension that is larger than a second defining dimension. The lumen extends from the lumen openings and through the elongate structures. The lumen openings are positioned proximal to the elongate structure'"'"'s distal portion. In one embodiment an array of a plurality of the elongate structures are provided. In another embodiment, the elongate structures are microneedles.
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Citations
25 Claims
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1. A surface penetration device comprising:
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a substrate comprising an upper surface and a backside; a tapered elongate structure extending from and supported by the substrate upper surface, the elongate structure comprising a distal portion, a proximal portion supported at the substrate upper surface, a lumen, wherein a cross section of the lumen is asymmetrical and comprises a first defining dimension that is larger than a second defining dimension, and a plurality of lumen openings, wherein the lumen extends from the lumen openings and through the elongate structure, and wherein at least one lumen opening comprises an elongate geometry and is positioned proximal to the elongate structure'"'"'s distal portion. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A method of accessing interstitial fluid comprising:
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providing a microneedle device comprising a substrate and one or more tapered elongate structures supported by the substrate, wherein the elongate structures each comprise a lumen, a plurality of lumen openings, and wherein at least one lumen opening comprises an elongate geometry; penetrating a skin surface with the elongate structures; and delivering a substance to or sampling a substance associated with interstitial fluid. - View Dependent Claims (17, 18)
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19. A method of manufacturing a surface penetration device comprising:
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providing a substrate comprising front side and a backside; forming a backside opening and a lumen in the substrate, wherein the lumen extends distally from the backside opening, through the substrate, and ends proximal to the upper surface, and wherein a cross section of the lumen is asymmetrical and comprises a first defining dimension that is larger than a second defining dimension; providing a tip protection cap to a portion of the substrate front side, wherein the cap comprises a dimension; forming a trench in the uncapped portion of the substrate and a micro pillar in the capped portion of the substrate; sharpening the micro pillar to form a tapered elongate structure and at least one lumen opening comprising an elongate geometry in communication with the lumen. - View Dependent Claims (20, 21, 22, 23, 24, 25)
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Specification