Catheter for cell delivery
First Claim
1. A cell delivery system for localized delivery of cells, the cell delivery system comprising a tube with a distal portion configured to deliver cells to a tissue in a pressure controlled manner, wherein the distal portion has a sheath comprising a plurality of apertures.
1 Assignment
0 Petitions
Accused Products
Abstract
A cell delivery system and method for delivering cells locally to a tissue, body cavity, or joint is described. The cell delivery system comprises a catheter configured to deliver stem cells in a pressure controlled manner. The catheter may comprise an inner bladder and an outer perforated bladder. The inner bladder may be expanded through the use of a pressure conduit in order to deploy a stent. Cells, such as endothelial cells derived from adipose tissue, may be introduced between the inner and outer bladder. The inner bladder may be further expanded in order to exert pressure on the outer perforated bladder to advance the stems cells though the apertures of the outer bladder. The inner bladder may remain pressurized to hold the outer bladder against the vessel wall, thereby directing the stem cells to specific target sites. The system may be used to deliver stem cells with or without other therapeutic agents. The system may be used with or without a stent. The system may further comprise a pressure gauge that permits measurement and regulation of pressure within the catheter.
-
Citations
68 Claims
- 1. A cell delivery system for localized delivery of cells, the cell delivery system comprising a tube with a distal portion configured to deliver cells to a tissue in a pressure controlled manner, wherein the distal portion has a sheath comprising a plurality of apertures.
- 33. A method of delivering cells locally to a tubular tissue, the method comprising deploying a biocompatible catheter into a tubular tissue, the catheter being sized and shaped to conform to and expand the tubular tissue, and applying pressure to a catheter in a controlled manner.
-
39. A method of delivering stem cells to the lumenal surface of a tubular tissue, comprising:
-
providing a catheter having a proximal end and a distal end, defining a lumen therebetween, the proximal end of said catheter comprising a fluid reservoir, the distal end of said catheter comprising an expandable balloon having a plurality of apertures;
filling the fluid reservoir with cells and fluid;
applying pressure to proximal end of the catheter;
advancing the cells from the fluid reservoir to the lumen of the catheter;
expanding the balloon proximate the luminal surface of the tubular tissue;
delivering the cells and fluid through the apertures of the balloon to the luminal surface of the tubular tissue;
sustaining the pressure on the balloon, thereby maintaining a pressure gradient between the lumen of the catheter and the luminal surface of the tubular tissue and advancing the cells from the lumen of the catheter onto the luminal surface of the tubular tissue;
releasing the pressure on the lumen of the catheter; and
deflating the balloon. - View Dependent Claims (40, 41, 42, 43, 44, 56, 57, 58, 59, 60, 61, 62, 63, 64)
-
-
65. A catheter configured to deliver cells to the lumenal surface of a tubular tissue comprising:
-
dual coaxially mounted tubes;
a double layered balloon in communication with the tubes, said balloon having an inner chamber concentrically positioned within an outer chamber in a spaced apart relationship defining an annular lumen therebetween;
wherein the outer chamber of the balloon comprises a plurality of apertures;
wherein cells are disposed within the annular lumen of the balloon; and
wherein the balloon is configured to deliver cells to the lumenal surface of a tubular tissue through the apertures of the outer chamber. - View Dependent Claims (66, 67, 68)
-
Specification