Personal paramedic

• US 20080058772A1
• Filed: 08/31/2007
• Published: 03/06/2008
• Est. Priority Date: 08/31/2006
• Status: Abandoned Application

• Current Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Original Assignee: Proteus Biomedical, Inc. (Otsuka Holdings Company Limited)
• Inventors: Hafezi, Hooman, Robertson, Timothy L.
• Application Number:
  US11/897,931
• Publication Number:
  US 20080058772A1
• Time in Patent Office: Days
• US Class Current: 604/890.1
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L

Abstract

A drug delivery device is provided. The device is configured to be automatically activated by a wireless signal sent from a sensor or from another implantable device. Embodiments of the device include a drug reservoir, a delivery mechanism, an energy source, and a processor which activates the delivery mechanism upon receiving the wireless automatically generated signal. The device can operate with a battery, or with an energy source that can harvest ambient energy (e.g. from a defibrillator pulse). Also provided are systems and kits having components thereof, and methods of using the subject devices.

Claims

1. A device comprising:

a reservoir comprising an active agent;

a delivery mechanism configured to release said active agent from said reservoir upon activation;

an energy source; and

a processor configured to activate said delivery mechanism upon receipt of a wirelessly transmitted automatically generated stimulus signal.

2. The device according to claim 1, wherein said energy source is configured to harvest ambient energy.

3. The device according to claim 1, wherein said ambient energy is a defibrillation pulse.

4. The device according to claim 1, wherein said energy source comprises a battery.

5. The device according to claim 1, wherein said automatically generated stimulus signal is produced by a second device.

6. The device according to claim 5, wherein said second i device is an implantable pulse generator.

7. The device according to claim 5, wherein said second device is configured to transmit said automatically generated stimulus signal upon receipt of a signal from a sensor.

8. The device according to claim 7, wherein said sensor measures a physiological parameter in the body.

9. The device according to claim 7, wherein said sensor is part of said second medical device.

10. The device according to claim 7, wherein said sensor is present on a third medical device.

11. The device according to claim 1, wherein said device comprises two or more reservoirs comprising an active agent.

12. The device according to claim 1, wherein said two or more reservoirs comprise the same active agent.

13. The device according to claim 1, wherein said two or more reservoirs comprise a different active agent.

14. The device according to claim 1, wherein said delivery mechanism comprises one or more electrodes.

15. The device according to claim 1, wherein said delivery mechanism is configured to release said active agent from said reservoir in less than one second.

16. The device according to claim 1, wherein said active agent is a drug.

17. The device according to claim 1, wherein said wirelessly transmitted automatically generated stimulus signal is a conductive transmission signal.

18. The device according to claim 1, wherein said device is an external device.

19. The device according to claim 1, wherein said device is an implantable device.

20. The device according to claim 19, wherein said implantable device has a stent configuration.

24. A system for delivering an active agent into a subject, comprising:

an implantable device according to claim 1; and

a second implantable medical device.

25. A system according to claim 24, further comprising a third implantable medical device.

26. The system according to claim 24, wherein said energy source is configured to harvest ambient energy.

27. The system according to claim 26, wherein said ambient energy is a defibrillation pulse.

28. A kit comprising:

an implantable device according to claim 1.

29. A kit according to claim 28, wherein said kit further includes a second implantable medical device.

30. A kit according to claim 29, wherein said kit further includes a third implantable medical device.

31. A kit according to claim 28, wherein said implantable device has a stent configuration.

21. A method for delivering an active agent to a subject, comprising:

(a) providing a patient having an implanted device comprising;

(i) a reservoir comprising an active agent;

(ii) a delivery mechanism configured to release said active agent from said reservoir upon activation;

(iii) an energy source; and

(iV) a processor configured to activate said delivery mechanism upon receipt of a wirelessly transmitted automatically generated stimulus signal;

(b) wirelessly transmitting said automatically generated stimulus signal to said device; and

(c) releasing said active agent from said reservoir.

22. The method according to claim 21, wherein said method further comprises harvesting ambient energy using said energy source.

23. The method according to claim 22, wherein said ambient energy is a defibrillation pulse.