CONTROLLED TITRATION OF NEUROSTIMULATION THERAPY
First Claim
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1. An implantable device for delivering neurostimulation, comprising:
- a pulse generator for outputting neural stimulation pulses;
one or more stimulation electrodes connected to the pulse generator for delivering electrical stimulation to a selected neural site;
a controller connected to the pulse generator for controlling the output of neural stimulation pulses in accordance with a defined schedule and specified stimulation parameters;
a telemetry unit interfaced to the controller for enabling user input of a defined schedule for delivering neurostimulation and specified stimulation parameters; and
,wherein the controller is programmed to receive medication dosage information via telemetry and modify the schedule for delivering neurostimulation accordingly.
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Abstract
Described herein are methods and devices that utilize electrical neural stimulation to treat heart failure by modulating a patient'"'"'s autonomic balance in a manner that inhibits sympathetic activity and/or augments parasympathetic activity. Because other therapies for treating heart failure may also affect a patient'"'"'s autonomic balance, a device for delivering neural stimulation is configured to appropriately titrate such therapy in either an open-loop or closed-loop fashion.
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Citations
23 Claims
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1. An implantable device for delivering neurostimulation, comprising:
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a pulse generator for outputting neural stimulation pulses; one or more stimulation electrodes connected to the pulse generator for delivering electrical stimulation to a selected neural site; a controller connected to the pulse generator for controlling the output of neural stimulation pulses in accordance with a defined schedule and specified stimulation parameters; a telemetry unit interfaced to the controller for enabling user input of a defined schedule for delivering neurostimulation and specified stimulation parameters; and
,wherein the controller is programmed to receive medication dosage information via telemetry and modify the schedule for delivering neurostimulation accordingly. - View Dependent Claims (2, 3, 4, 5)
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6. An implantable device for delivering neurostimulation, comprising:
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a pulse generator for outputting neural stimulation pulses; one or more stimulation electrodes connected to the pulse generator for delivering electrical stimulation to a selected neural site; a controller connected to the pulse generator for controlling the output of neural stimulation pulses in accordance with a defined schedule and specified stimulation parameters; a telemetry unit interfaced to the controller for enabling user input of a defined schedule and stimulation parameters for delivering neurostimulation; one or more sensing modalities for sensing a physiological variable reflective of a patient'"'"'s autonomic balance; wherein the stimulation electrodes are configurable for delivering stimulation to the vagus nerve or a baroreceptor of the patient and wherein the controller is programmed to adjust the amount of neurostimulation delivered in accordance with a determination of the patient'"'"'s autonomic balance. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14)
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15. A method, comprising:
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programming an implantable device to delivery neural stimulation pulses to a selected neural site in accordance with a defined schedule and specified stimulation parameters; and
,programming the implantable device to receive medication dosage information via telemetry and modify the schedule for delivering neurostimulation accordingly. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23)
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Specification