THERAPEUTIC METHOD WITH PAIN RELIEF

• US 20080058878A1
• Filed: 10/31/2007
• Published: 03/06/2008
• Est. Priority Date: 05/17/2001
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: King, Gary
• Granted Patent: US 8,165,672 B2
• Time in Patent Office: Days
• US Class Current: 607/5
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/39624 Pain reduction therapy

Abstract

A desired effect is produced by therapeutically activating tissue at a first site within a patient'"'"'s body and a corresponding undesired side effect is reduced by blocking activation of tissue or conduction of action potentials at a second site within the patient'"'"'s body by applying high frequency stimulation and/or direct current pulses at or near the second site. Timex varying DC pulses may be used before or after a high frequency blocking signal. The high frequency stimulation may begin before and continue during the therapeutic activation. The high frequency stimulation may begin with a relatively low amplitude, and the amplitude may be gradually increased. The desired effect may be defibrillation of the patient'"'"'s atria or defibrillation of the patient'"'"'s ventricles, and the undesired side effect may be pain.

Claims

1. A method of blocking undesirable side effect activation of electrically excitable tissue wherein the undesirable side effect is pain, the method comprising the steps of:

therapeutically activating tissue at a first predetermined site within a patient'"'"'s body; and

blocking activation of tissue or conduction of action potentials at a second predetermined site within the patient'"'"'s body by applying high frequency stimulation or one or more direct current pulses or both high frequency stimulation and one or more direct current pulses at or near the second site.

2. The method of claim 1, wherein the desired effect is selected from the group consisting of:

defibrillation of the patient'"'"'s atria or defibrillation of the patient'"'"'s ventricles.

3. The method of claim 2, wherein:

the first site is selected from the group consisting of;

a heart pacing lead inside the patient'"'"'s heart chambers and a heart pacing lead outside the patient'"'"'s heart chambers.

4. The method of claim 3, wherein:

the second site is selected from the group consisting of the patient'"'"'s;

vagus nerve, branches of the patient'"'"'s vagus nerve from the patient'"'"'s heart, thoracic sympathetic nerves, ansa subclavia, sympathetic trunk ganglia (T1-T4), stellate ganglia, cervical ganglia (C1-C8), celiac plexus, brachial plexi, dorsal roots (C1-T4), spinal dorsal columns, and dorsal roots.

5. The method of claim 2, wherein:

the second site is selected from the group consisting of the patient'"'"'s. vagus nerve, branches of the patient'"'"'s vagus nerve from the patient'"'"'s heart. thoracic sympathetic nerves, ansa subclavia, sympathetic trunk ganglia (T1-T4), stellate ganglia, cervical ganglia (Cl -C8), celiac plexus, brachial plexi, dorsal roots (C1-T4), spinal dorsal columns, and dorsal roots.

6. The method of claim 1, wherein:

the second site is selected from the group consisting of the patient'"'"'s vagus nerve, branches of the patient'"'"'s vagus nerve from the patient'"'"'s heart, thoracic sympathetic nerves, ansa subclavia, sympathetic trunk ganglia (T1-T4), stellate ganglia, cervical ganglia (C1-C8), celiac plexus, brachial plexi, dorsal roots (C1-T4), spinal dorsal columns, and dorsal roots.

7. The method of claim 2, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses begin before and continue during the therapeutic activation.

8. The method of claim 2, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses begin with a relatively low amplitude and the amplitude is gradually increased.

9. The method of claim 2, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses are terminated by gradually reducing the amplitude of the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses.

10. The method of claim 2, further comprising the steps of:

sensing a state of the tissue at the second site or at a site that is remote from both the first site and the second site; and

in response to the sensing step, adjusting at least one parameter of the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses, the parameter being selected from the group consisting of;

pulse amplitude, pulse width, pulse frequency, pulse duty cycle, pulse polarity, and pulse waveform.

11. The method of claim 2, further comprising:

sensing a state of the tissue at the second site or at a site remote from both the first site and the second site; and

in response to an indication from the sensor that tissue at the second site is activated, applying the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses to the second site.

13. A method of blocking undesirable side effect activation of electrically excitable tissue, wherein such undesirable side effect activation includes pain, the method comprising the steps of:

therapeutically activating tissue at a first predetermined site within a patient'"'"'s body by applying low frequency stimulation at or near the first predetermined site; and

blocking activation of tissue or conduction of action potentials at a second predetermined site within the patients body by applying high frequency stimulation or one or more direct current pulses or both high frequency stimulation and one or more direct current pulses at or near the second site such that the high frequency stimulation and/or the direct current pulses prevent the low frequency stimulation applied at the first site from activating the electrically excitable tissue, or causing conduction of action potentials, at the second site.

14. The method of claim 13, wherein the desired effect is selected from the group consisting of defibrillation of the patient'"'"'s atria or defibrillation of the patient'"'"'s ventricles.

15. The method of claim 14, wherein the first site is selected from the group consisting of:

a heart pacing lead inside the patient'"'"'s heart chambers and a heart pacing lead outside the patient'"'"'s heart chambers.

16. The method of claim 15, wherein:

the second site is selected from the group consisting of the patient'"'"'s;

vagus nerve, branches of the patient'"'"'s vagus nerve from the patient'"'"'s heart, thoracic sympathetic nerves, ansa subclavia, sympathetic trunk ganglia (T1-T4) stellate ganglia, cervical ganglia (C1-C8), celiac plexus, brachial plexi, dorsal roots (C1-T4), spinal dorsal columns, and dorsal roots.

17. The method of claim 14, wherein:

the second site is selected from the group consisting of the patient'"'"'s;

vagus nerve, branches of the patient'"'"'s vagus nerve from the patient'"'"'s heart, thoracic sympathetic nerves, ansa subclavia, sympathetic trunk ganglia (T1-T4), stellate ganglia, cervical ganglia (C1-C8), celiac plexus, brachial plexi, dorsal roots (C1-T4), spinal dorsal columns, and dorsal roots.

18. The method of claim 13, wherein, the second site is selected from the group consisting of the patient'"'"'s:

vagus nerve, branches of the patient'"'"'s vagus nerve from the patient'"'"'s heart, thoracic sympathetic nerves, ansa subclavia, sympathetic trunk ganglia (T1-T4), stellate ganglia, cervical ganglia (C1-C8), celiac plexus, brachial plexi, dorsal roots (C1-T4), spinal dorsal columns, and dorsal roots.

19. The method of claim 14, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses begin before and continue during the therapeutic activation.

20. The method of claim 14, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses begin with a relatively low amplitude and the amplitude is gradually increased.

21. The method of claim 14, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses are terminated by gradually reducing the amplitude of the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses.

22. A method of stimulating tissue within a patient'"'"'s body while blocking undesirable side effect activation of electrically excitable tissue, wherein such undesirable side effect activation includes pain, the method comprising the steps of:

implanting a tissue stimulating system in the patient'"'"'s body with a first electrode at or near a first predetermined site within the patient'"'"'s body and a second electrode at or near a second predetermined site within the patient'"'"'s body;

therapeutically activating tissue at the first predetermined site within a patient'"'"'s body by applying low frequency stimulation at or near the first predetermined site with the first electrode; and

blocking activation of tissue or conduction of action potentials at a second predetermined site within the patient'"'"'s body by applying high frequency stimulation or one or more direct current pulses or both high frequency stimulation and one or more direct current pulses at or near the second site with the second electrode such that the high frequency stimulation and/or the direct current pulses prevent the low frequency stimulation applied at the first site from activating the electrically excitable tissue, or causing conduction of action potentials, at the second site.

23. The method of claim 22, wherein the desired effect is selected from the group consisting of:

defibrillation of the patient'"'"'s atria or defibrillation of the patient'"'"'s ventricles.

24. The method of claim 23, wherein:

the first site is selected from the group consisting of;

a heart pacing lead inside the patient'"'"'s heart chambers and a heart pacing lead outside the patient'"'"'s heart chambers; and

the second site is selected from the group consisting of the patient'"'"'s;

vagus nerve, branches of the patient'"'"'s vagus nerve from the patient'"'"'s heart, thoracic sympathetic nerves, ansa subclavia, sympathetic trunk ganglia (T1-T4), stellate ganglia, cervical ganglia (C1-C8), celiac plexus, brachial plexi, dorsal roots (C1-T4), spinal dorsal columns, and dorsal roots.

25. The method of claim 23, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses begin before and continue during the therapeutic activation.

26. The method of claim 23, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses begin with a relatively low amplitude and the amplitude is gradually increased.

27. The method of claim 23, wherein the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses are terminated by gradually reducing the amplitude of the high frequency stimulation or the direct current pulses or both the high frequency stimulation and the direct current pulses.