PROGRAMMABLE NEURAL THERAPIES

• US 20080058901A1
• Filed: 11/01/2006
• Published: 03/06/2008
• Est. Priority Date: 11/01/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Haefner, Paul A., Ternes, David
• Granted Patent: US 8,024,034 B2
• Time in Patent Office: Days
• US Class Current: 607/59
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36175 Pulse width or duty cycle
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: G16Z 99/00 Subject matter not provided for in other main groups of this subclass

Abstract

An implantable medical device (IMD) comprising a controller adapted to execute instructions included in firmware, a programmable neural therapy source adapted to provide programmable electrical neural stimulation therapy to at least one neural stimulation electrode, and a state machine included in hardware circuitry coupled to the programmable neural therapy source. When neural therapy is initiated by a firmware instruction, the state machine is configured to automatically apply power to the neural therapy source when neural therapy is initiated by a firmware instruction and automatically remove power from the neural therapy source when neural therapy is terminated by a firmware instruction.

Claims

1. An implantable medical device (IMD) comprising:

a controller adapted to execute instructions included in firmware;

a programmable neural therapy source adapted to provide programmable electrical neural stimulation therapy to at least one neural stimulation electrode; and

a state machine included in hardware circuitry coupled to the programmable neural therapy source, the state machine configured to automatically apply power to the neural therapy source when neural therapy is initiated by a firmware instruction and automatically remove power from the neural therapy source when neural therapy is terminated by a firmware instruction.

2. The IMD of claim 1, wherein, when neural therapy is initiated by a firmware instruction, the state machine is adapted to automatically apply power to the neural therapy source during an active portion of a therapy duty cycle and to remove power from the neural therapy source when exiting the active portion of a therapy duty cycle.

3. The IMD of claim 2, wherein the state machine is adapted to apply power to the neural therapy source during an electrical neural therapy stimulation pulse and to remove power from the neural therapy source after the electrical neural therapy stimulation pulse.

4. The IMD of claim 2, wherein the state machine is adapted to apply power to the neural therapy source during a burst of associated electrical neural therapy stimulation pulses, and to remove power from the neural therapy source after the burst of electrical neural therapy stimulation pulses.

5. The IMD of claim 2, wherein the programmable neural therapy source includes a programmable current source, and wherein the state machine is adapted to apply power to the programmable current source during an envelope of time that begins an amount of time before the active portion of a therapy duty cycle that is sufficient to activate the programmable current source, and to remove power when the active portion of a therapy duty cycle ends.

6. The IMD of claim 5, wherein the state machine is adapted to apply power to the programmable current source within a range of approximately ten microseconds (10 μ

s) to five milliseconds (5 ms) before the active portion of a therapy duty cycle.

7. The IMD of claim 1, wherein the state machine includes one or more hardware registers writeable by the controller, and wherein the hardware registers include one or more fields that define the programmable electrical neural stimulation therapy including a field to program one or more electrical stimulation pulses to be included in an active portion of a therapy duty cycle and one or more pulse times to be included in an inactive portion of a therapy duty cycle.

8. The IMD of claim 7, wherein at least one hardware register includes a field to program one or more duty cycles to issue upon a neural therapy trigger from the controller.

9. The IMD of claim 7, wherein at least one hardware register includes a field to programmably ramp a number of electrical stimulation pulses to be included in the active portion of a therapy duty cycle.

10. The IMD of claim 7, wherein at least one hardware register includes a field to program a frequency of electrical stimulation pulses to be included in a therapy duty cycle.

11. The IMD of claim 7, wherein at least one hardware register includes a field to programmably change a frequency of pulses between duty cycles.

12. The IMD of claim 7, wherein at least one hardware register includes a field to programmably change an amplitude of electrical stimulation pulses included in the active portion of a therapy duty cycle.

13. The IMD of claim 7, wherein at least one hardware register includes a field to program an amplitude envelope of electrical stimulation pulses included in a duty cycle.

14. The IMD of claim 7, wherein at least one hardware register includes a field to programmably ramp amplitudes of electrical stimulation pulses to be included in the active portion of a therapy duty cycle.

15. The IMD of claim 1 further including:

a cardiac signal sensing circuit operable to produce a signal representative of cardiac activity of a subject; and

a pacing circuit for delivering an electrical stimulation pulse to a pacing electrode.

16. A method comprising the acts of:

initiating neural stimulation therapy using at least one instruction included in firmware of an implantable medical device (IMD);

automatically delivering, in response to the firmware instruction, an electrical neural stimulation therapy to a non-cardiac neural stimulation electrode using a state machine included in hardware in the IMD; and

automatically applying power to a neural stimulation therapy source of the IMD using the state machine and removing power from the neural therapy source when neural therapy is terminated by the firmware.

17. The method of claim 16, wherein applying power further includes powering the neural therapy source during an active portion of a therapy duty cycle and removing power from the neural therapy source when exiting the active portion of a therapy duty cycle.

18. The method of claim 17, wherein powering includes powering the neural therapy source during an electrical neural therapy stimulation pulse and removing power from the neural therapy source after the electrical neural therapy stimulation pulse.

19. The method of claim 17, wherein powering includes powering the neural therapy source during a burst of associated electrical neural stimulation pulses and removing power from the neural therapy source after the burst of electrical neural therapy stimulation pulses.

20. The method of claim 17, wherein powering includes:

powering the neural stimulation therapy source during a time prior to the active portion to activate the neural stimulation therapy source that is sufficient to activate the programmable current source; and

removing power when the active portion of a therapy duty cycle ends.

21. The method of claim 16, wherein automatically delivering an electrical neural stimulation therapy includes writing at least one hardware register in the state machine to program an electrical neural stimulation therapy.

22. The method of claim 21 including writing at least one hardware register to program one or more electrical stimulation pulses to be included in the active portion of a therapy duty cycle and one or more pulse times to be included in an inactive portion of a therapy duty cycle.

23. The method of claim 21 including writing at least one hardware register to program one or more duty cycles to issue upon a neural therapy trigger from a firmware instruction.

24. The method of claim 21 including writing at least one hardware register to programmably ramp a number of electrical stimulation pulses to be included in the active portion of a therapy duty cycle.

25. The method of claim 21 including writing at least one hardware register to program an amplitude envelope function of electrical stimulation pulses in a duty cycle.

26. The method of claim 21 including writing at least one hardware register to programmably change a time between electrical stimulation pulses within a same burst.

27. The method of claim 16, further including delivering an electrical pacing pulse to a pacing electrode in association with the electrical neural stimulation therapy.