Method for correcting a spectral image for optical aberrations using software
First Claim
1. A method for correcting a spectral image for optical aberrations, the method comprising the acts of:
- exposing tissue to a high-intensity, narrow band of light, the narrow band of light being scattering by at least one analyte in the tissue;
optically collecting Raman signals from the scattered light;
directing the Raman signals to a wavelength-separating device;
detecting the Raman signals as a function of intensity and wavelength to create the spectral image; and
correcting the spectral image for optical aberrations using a software algorithm to spatially reassign intensity.
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Accused Products
Abstract
A spectral image is corrected for optical aberrations. Tissue is exposed to a high-intensity, narrow band of light. The narrow band of light is scattered by at least one analyte in the tissue. Raman signals are optically collected from the scattered light. The Raman signals are directed to a wavelength-separating device. The Raman signals are detected as a function of intensity and wavelength to create the spectral image. The spectral image is corrected for optical aberrations using a software algorithm to spatially reassign intensity. The software may be adapted to use a reference image to make dynamic corrections. Fluorescence signals may also be collected.
38 Citations
20 Claims
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1. A method for correcting a spectral image for optical aberrations, the method comprising the acts of:
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exposing tissue to a high-intensity, narrow band of light, the narrow band of light being scattering by at least one analyte in the tissue;
optically collecting Raman signals from the scattered light;
directing the Raman signals to a wavelength-separating device;
detecting the Raman signals as a function of intensity and wavelength to create the spectral image; and
correcting the spectral image for optical aberrations using a software algorithm to spatially reassign intensity. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for determining the concentration of at least one analyte in a fluid, the method comprising the acts of:
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exposing skin tissue to a high-intensity, narrow band of light, the narrow band of light being scattering by at least one analyte in the tissue;
optically collecting the Raman signals from the scattered light;
directing the Raman signals to a wavelength-separating device;
detecting the Raman signals as a function of intensity and wavelength to create the spectral image;
correcting the spectral image for optical aberrations using a software algorithm to spatially reassign intensity; and
determining the concentration of the at least one analyte using the corrected spectral image. - View Dependent Claims (11, 12, 13, 14, 15)
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16. A method for correcting a spectral image for optical aberrations using an instrument, the method comprising the acts of:
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exposing tissue to a high-intensity band of light;
optically collecting an image of the tissue;
dynamically correcting the image using software to optically correct for at least one of the instrument and tissue; and
using information from the corrected image to perform a general diagnosis.
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17. A method for correcting a spectral image for optical aberrations using an instrument, the method comprising the acts of:
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exposing tissue to a high-intensity light, the light being scattering by at least one analyte in the tissue;
optically collecting fluorescence signals from the scattered light;
directing the fluorescence signals to a wavelength-separating device;
detecting the fluorescence signals as a function of intensity and wavelength to create the spectral image; and
correcting the spectral image for optical aberrations using a software algorithm to spatially reassign intensity. - View Dependent Claims (18)
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19. A method for correcting a spectral image for optical aberrations, the method comprising the acts of:
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optically collecting Raman signals from the scattered light;
directing the Raman signals to a wavelength-separating device;
detecting the Raman signals as a function of intensity and wavelength to create the spectral image; and
correcting the spectral image for optical aberrations using a software algorithm to spatially reassign intensity.
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20. A method for correcting a spectral image for optical aberrations using an instrument, the method comprising the acts of:
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optically collecting fluorescence signals from the scattered light;
directing the fluorescence signals to a wavelength-separating device;
detecting the fluorescence signals as a function of intensity and wavelength to create the spectral image; and
correcting the spectral image for optical aberrations using a software algorithm to spatially reassign intensity.
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Specification