Electrophoresis apparatus having an outlet passage
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Abstract
An electrophoresis apparatus is generally disclosed for sequentially analyzing a single sample or multiple samples having one or more analytes in high or low concentrations. The apparatus comprises a relatively large-bore transport capillary which intersects with a plurality of small-bore separation capillaries. Analyte concentrators, having antibody-specific (or related affinity) chemistries, are stationed at the respective inter-sections of the transport capillary and separation capillaries to bind one or more analytes of interest. The apparatus allows the performance of two or more dimensions for the optimal separation of analytes.
73 Citations
52 Claims
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1-28. -28. (canceled)
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29. An electrophoresis apparatus, comprising:
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a transport passage having an inlet entrance and an exit outlet;
a first separation passage which intersects with the transport passage at a first intersection;
the first separation passage having an inlet entrance and an exit outlet;
a first concentrator to concentrate a first analyte;
the first concentrator being positioned at the first intersection;
a second separation passage which intersects with the transport passage at a second intersection;
the second separation passage having an inlet entrance and an exit outlet;
a second concentrator to concentrate a second analyte;
the second concentrator being positioned at the second intersection;
an outlet passage;
the first separation passage to convey to the outlet passage the first analyte concentrated by the first concentrator from a sample introduced into the transport passage;
the second separation passage to convey to the outlet passage the second analyte concentrated by the second concentrator from the sample introduced into the transport passage; and
a detector to identify and characterize the first and second analytes when delivered sequentially thereto in the outlet passage. - View Dependent Claims (30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52)
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Specification