Breath analyzer

• US 20080061238A1
• Filed: 01/25/2007
• Published: 03/13/2008
• Est. Priority Date: 09/13/2006
• Status: Active Grant

• Current Assignee: SenseAir AB (Asahi Kasei Corporation)
• Original Assignee: Autoliv Development AB (Autoliv Incorporated)
• Inventors: Hok, Bertil, Pettersson, Hakan
• Granted Patent: US 7,919,754 B2
• Time in Patent Office: Days
• US Class Current: 250/340
• CPC Class Codes: B60K 28/06 responsive to incapacity of driver
• CPC Class Codes: B60W 2540/24 Drug level, e.g. alcohol
• CPC Class Codes: G01N 21/0332 with temperature control control of temperature G05D23/00; cryostats F17C3/08
• CPC Class Codes: G01N 21/3504 for analysing gases, e.g. multi-gas analysis
• CPC Class Codes: G01N 2201/06186 Resistance heated; wire sources; lamelle sources
• CPC Class Codes: G01N 33/497 of gaseous biological material, e.g. breath
• CPC Class Codes: G01N 33/4972 Determining alcohol content for vehicle safety devices B60K28/06

Abstract

A system for the detection and analysis of at least one volatile substance in breath samples of a subject, including at least one source of infrared radiation adapted to the wavelength range of specific absorption peaks of said substances, a plurality of reflecting surfaces of said radiation adapted for collimation onto at least one detector providing a plurality of electrical output signals corresponding to the transmission of said radiation within wavelength intervals corresponding to said absorption peaks, at least one measuring cell including a mechanical support structure defining the position of said source, reflecting surfaces and detector, adapted to the reception and disposal of said breath sample, and exposing it to said radiation, at least one electronic signal processing unit with capacity to analyse said signals with respect to pre-programmed information concerning infrared absorption spectra of said substances. The response of the system being displayed or otherwise communicated, and perceived as essentially instantaneous.

Claims

1. A system for the detection and analysis of at least one volatile substance in breath samples of a subject comprising:

at least one source of infrared radiation adapted to the wavelength range of specific absorption peaks of the substances;

a plurality of reflecting surfaces of the radiation;

at least one detector receiving the radiation providing electrical output signals corresponding to the transmission of the radiation within wavelength intervals corresponding to the absorption peaks;

at least one measuring cell including a mechanical support structure defining the position of the source, the reflecting surfaces and the detector, adapted for the reception and flow of the breath sample, and exposing the breath samples to the radiation;

at least one electronic signal processing unit with capacity to analyze the signals with respect to pre-programmed information concerning infrared absorption spectra of the substances; and

a response of the system being displayed or otherwise communicated, and perceived as essentially instantaneous.

2. A system according to claim 1 for the detection and analysis of a plurality of volatile substances.

3. A system according to claim 1 wherein the response of the system being mainly determined by the transit time of the breath sample through the measuring cell.

4. A system according to claim 1 wherein the response of the system being less than ten seconds.

5. A system according to claim 1 wherein the sample being collected in free air in the close vicinity of the subject.

6. A system according to claim 1 further comprising at least one replaceable mouthpiece adapted for leak-proof connection between the measuring cell and the mouth of the subject.

7. A system according to claim 1 wherein the measuring cell having an inlet and outlet openings of sufficient cross section area to maintain essentially laminar air flow within said measuring cell of the breath samples and regions of stagnant flow of the breath samples within the measuring cell occupying less than 10% of the transmission path of the radiation.

8. A system according to claim 1 wherein the measuring cell having a tubular structure.

9. A system according to claim 1 further comprising a means for the active transport of the breath sample through the measuring cell in the form of a pump or a fan.

10. A system according to claim 1 wherein the source is a heated filament constituting essentially a blackbody radiator, adapted for a modulation period shorter than the visual reaction time of normal subjects.

11. A system according to claim 1 wherein the path length of the radiation is larger than the physical dimensions of said measuring cell.

12. A system according to claim 1 wherein at least one of the reflecting surfaces being at least partly concave, exhibiting a reflectance coefficient to the radiation exceeding 0.99, each surface segment of the concave reflecting surface coinciding at one point with the centre of radius of curvature of an opposing surface.

13. A system according to claim 1 wherein the radiation is at least partly collimated, and subjected to a plurality of reflections by the reflecting surfaces, the number exceeding five.

14. A system according to claim 1 further comprising at least one dispersive or absorptive element including at least one interference filter, or a high-resolution diffractive grating with fixed or electronically controllable properties.

15. A system according to claim 1 wherein the detector being a thermopile or a pyroelectric element.

16. A system according to claim 1 wherein the electronic signal processing unit includes at least one memory device for information storage, and providing the execution of pre-programmed sequence of logical and arithmetic operations.

17. A system according to claim 1 wherein the substances being carbon dioxide, whereby the measurement of the concentration of carbon dioxide in the close vicinity of the subject being used, in combination with an estimated value of alveolar carbon dioxide concentration of the subject, to determine the degree of dilution of the breath sample.

18. A system according to claim 1 wherein the substances being ethyl alcohol or any other agent capable of affecting the subject'"'"'s behaviour.

19. A system according to claim 1 further comprising a display means directed to the subject for communicating an instruction to provide the breath sample by forced expiration directed towards the measuring cell.

20. A system according to claim 1 wherein the support structure being transformable between one active operational condition in which openings to receive and dispose of the breath sample are provided, and one passive condition, in which the source, the reflecting surface, and the detector are protected from ambient exposure.

21. A system according to claim 20 further comprising electromechanical means for alternation between the conditions.

22. A system according to claim 21 wherein the alternation between the conditions is partly or fully automatic.

23. A system according to claim 1 further comprising a support structure for housing the source, the reflecting surfaces, and the detector thereby forming a confined, and physically integral unit, adapted as a handheld unit, or for stationary installation in a vehicle.

24. A system according to claim 1 wherein the system analyses a plurality of the substances and the signals have minimum cross sensitivities between the determinations of the substances.

25. A system according to claim 1 wherein the support structure is adapted for the attachment of at least one mouthpiece, by which an undiluted breath sample may be collected.

26. A system according to claim 1 wherein the response indicates whether the substances originate from the upper or lower respiratory tract.

27. A system according to claim 1 wherein the support structure being assembled from parts fabricated by injection moulding.

28. A system according to claim 1 further comprising at least one sensor for performing measurements of temperature or air flow velocity within the measuring cell.

29. A system according to claim 1 wherein the signal processing unit provides the compensation of undesired interdependencies by means of a negative feedback loop or incorporation into a calculation algorithm.

30. A system according to claim 1 wherein the system provides the real-time monitoring of the output signals, including breath-by-breath analysis of substance concentrations.

31. A system according to claim 1 wherein the signals after processing are determining a locking or unlocking condition for starting or driving a vehicle, or other machinery.

32. A method for the detection and analysis of at least one volatile substance in breath samples of a subject comprising the steps of:

positioning a measuring cell within the expiratory air flow of a subject, allowing the reception and disposal of the breath sample;

exposing the breath sample within the measuring cell to infrared radiation from at least one source within at least one wavelength range of specific absorption peaks of the substances;

detecting the radiation after passage through the breath sample and thereby providing a plurality of output signals corresponding to the transmission of the radiation within wavelength intervals corresponding to the absorption peaks;

the passage through the sample being elongated by a plurality of reflecting surfaces;

analysing the signals with respect to pre-programmed information concerning infrared absorption coefficients of the substances; and

displaying a response to the detection and analysis and enabling the response to be perceived as essentially instantaneous.

33. A method according to claim 32 for the detection and analysis of a plurality of volatile substances.

34. A method according to claim 32 wherein the response being determined by the transit time of the breath sample through the measuring cell.

35. A method according to claim 32 wherein the response to the detection being less than ten seconds.

36. A method according to claim 32 wherein the analysis including variations with time of said output signals.

37. A method according to claim 32 wherein the breath sample being collected and disposed of in free air in the close vicinity of the subject.

38. A method according to claim 32 further comprising assisting in the active transport of the breath sample through the measuring cell by means of a pump or fan.

39. A method according to claim 32 further comprising modulating the source, adapted for a modulation period shorter than the visual reaction time of a typical subject.

40. A method according to claim 32 wherein the dispersion or absorption of the radiation being performed by at least one interference filter, or high-resolution diffractive grating with fixed or electronically controllable properties.

41. A method according to claim 32 wherein the signal analysis being performed by at least one electronic signal processing unit including at least one memory device for temporary and permanent information storage, and at least one device for the execution of pre-programmed sequence of logical and arithmetic operations.

42. A method according to claim 32 wherein that one of the substances being carbon dioxide, whereby the measurement of the concentration of carbon dioxide in the close vicinity of the subject being used, in combination with an estimated value of alveolar carbon dioxide concentration, to determine the degree of dilution of the breath sample.

43. A method according to claim 32 wherein at least one of the substances being ethyl alcohol or any other agent related the subject'"'"'s health or behaviour.

44. A method according to claim 32 wherein the displaying being directed to the subject for providing the breath sample by forced expiration directed towards the support structure.

45. A method according to claim 32 wherein the displaying indicates whether the substances originate from the upper or lower respiratory tract.

46. A method according to claim 32 wherein the determination of the substances involving redundant operations, providing capability of self-testing with respect to common accidental or deliberate errors.

47. A method according to claim 32 further comprising compensating of undesired interdependencies of the signals by means of a negative feedback loop or incorporation into a calculation algorithm.

48. A system according to claim 32 wherein the system providing the real-time monitoring of the output signals, including breath-by-breath analysis of substance concentrations.

49. A system according to claim 32 wherein the signals after processing are determining a locking or unlocking condition for starting or driving a vehicle, or other machinery.