Sensor Unit and Reaction Field Cell Unit and Analyzer

• US 20080063566A1
• Filed: 09/01/2005
• Published: 03/13/2008
• Est. Priority Date: 09/03/2004
• Status: Abandoned Application

• Current Assignee: Mitsubishi Chemical Corporation (Mitsubishi Chemical Group Corp.)
• Original Assignee: Mitsubishi Chemical Corporation (Mitsubishi Chemical Group Corp.)
• Inventors: Ifuku, Yasuo, Mitani, Hiroshi, Kojima, Atsuhiko, Saitou, Haruyo, Nagao, Satoru, Matsumoto, Kazuhiko, Kato, Masanori
• Application Number:
  US11/661,853
• Publication Number:
  US 20080063566A1
• Time in Patent Office: Days
• US Class Current: 422/68.1
• CPC Class Codes: G01N 27/4145 specially adapted for biomolecules, e.g. gate electrode with immobilised receptors
• CPC Class Codes: G01N 27/4146 involving nanosized elements, e.g. nanotubes, nanowires
• CPC Class Codes: G01N 33/5438 Electrodes

Abstract

To improve convenience of a sensor unit using a transistor in analysis, a sensing gate for detection 117 of a sensor unit for detecting a detection target comprises a transistor part 103 having a substrate 108, a source electrode 111 and a drain electrode 112 provided on the substrate 108, a channel 113 forming a current path between the source electrode 111 and the drain electrode 112, and the sensing gate for detection 117 is provided with a gate body 115 fixed to the substrate 108 and a sensing part 116 capable of electrically conducting to the gate body 115 and on which a specific substance 123 capable of selectively interacting with the detection target is immobilized.

Claims

1-36. -36. (canceled)

37. :

A sensor unit for detecting a detection target, comprising;

a transistor part including a substrate, a source electrode and a drain electrode provided on said substrate, a channel forming a current path between said source electrode and said drain electrode, and a sensing gate for detection,

wherein said sensing gate for detection, comprises;

a gate body fixed to said substrate; and

a sensing part on which a specific substance capable of selectively interacting with the detection target is immobilized, and said sensing part being mechanically removable from said gate body and, when mounted on said gate body, being in a conduction state of said gate body.

38. :

A sensor unit as defined in claim 37,

wherein the sensor unit including two or more of said sensing parts.

39. :

A sensor unit as defined in claim 38,

wherein one said gate body is configured to conduct to two or more of said sensing parts.

40. :

A sensor unit as defined in claim 39, further comprising;

an electric connection switching part for switching conduction between said gate body and said sensing parts.

41. :

A sensor unit as defined in claim 37,

wherein two or more of said transistor parts are integrated.

42. :

A sensor unit as defined in claim 37,

wherein said channel is formed with a nano tube structure.

43. :

A sensor unit as defined in claim 42,

wherein said nano tube structure is selected from a group consisting of a carbon nano tube, a boron nitride nano tube, and a titania nano tube.

44. :

A sensor unit as defined in claim 42,

wherein defects are introduced in said nano tube structure.

45. :

A sensor unit as defined in claim 42,

wherein an electric characteristic of said nano tube structure has a property like metals.

46. :

A sensor unit as defined in claim 37, further comprising;

a reaction field cell unit including a flow channel causing a sample to flow therethrough,

wherein said sensing part is provided in said flow channel.

47. :

A sensor unit as defined in claim 37,

wherein said transistor part comprises a voltage application gate applying a voltage or an electric field to said channel.

63. :

An analytical apparatus, comprising;

a sensor unit as defined in claim 37.

64. :

An analytical apparatus as defined in claim 63,

wherein chemical reaction and immunological reaction can be analyzed by said sensor unit.

65. :

An analytical apparatus as defined in claim 63,

wherein measurements of at least one measurement group selected from groups consisting of an electrolytic concentration measurement group, a biochemical item measurement group, a blood gases concentration measurement group, a blood cell count measurement group, a blood coagulation ability measurement group, an immunological reaction measurement group, a nucleic acid-nucleic acid hybridization reaction measurement group, a nucleic acid-protein interaction measurement group, and a receptor-ligand interaction measurement group can be analyzed by said sensor unit.

66. :

An analytical apparatus as defined in claim 63,

wherein detection of two or more detection targets selected from a group consisting of at least one detection target selected from an electrolytic concentration measurement group, at least one detection target selected from a biochemical item measurement group, at least one detection target selected from a blood gases concentration measurement group, at least one detection target selected from a blood cell count measurement group, at least one detection target selected from a blood coagulation ability measurement group, at least one detection target selected from a nucleic acid-nucleic acid hybridization reaction measurement group, at least one detection target selected from a nucleic acid-protein interaction measurement group, at least one detection target selected from a receptor-ligand interaction measurement group, and at least one detection target selected from an immunological reaction measurement group can be analyzed by said sensor unit.

67. :

A analytical apparatus as defined in claim 63,

wherein measurements of at least one measurement group selected from groups consisting of an electrolytic concentration measurement group, a biochemical item measurement group, a blood gases concentration measurement group, a blood cell count measurement group, and a blood coagulation ability measurement group, and at least one measurement group selected from groups consisting of a nucleic acid-nucleic acid hybridization reaction measurement group, a nucleic acid-protein interaction measurement group, a receptor-ligand interaction measurement group, and an immunological reaction measurement group can be analyzed by said sensor unit.

68. :

An analytical apparatus as defined in claim 63,

wherein two or more detection targets selected for determining a specific disease or function can be detected.

48. :

A sensor unit for detecting a detection target, comprising;

a transistor part including a substrate, a source electrode and a drain electrode provided on said substrate, a channel forming a current path between said source electrode and said drain electrode, and a sensing gate for detection,

wherein said sensing gate for detection comprises;

a gate body fixed to said substrate; and

a sensing part which is mechanically removable from said gate body and, when mounted on said gate body, is in a conduction state to said gate body; and

the sensor unit comprises a reference electrode to which a voltage is applied so as to detect existence of the detection target by a change of the characteristic of said transistor part.

49. :

A sensor unit as defined in claim 48,

wherein the sensor unit includes two or more of said sensing parts.

50. :

A sensor unit as defined in claim 49,

wherein one said gate body is configured to conduct to two or more of said sensing parts.

51. :

A sensor unit as defined in claim 50, further comprising;

an electric connection switching part for switching conduction between said gate body and said sensing parts.

52. :

A sensor unit as defined in claim 48,

wherein two or more of said transistor parts are integrated.

53. :

A sensor unit as defined in claim 48,

wherein said channel is formed with a nano tube structure.

54. :

A sensor unit as defined in claim 53,

wherein said nano tube structure is selected from a group consisting of a carbon nano tube, a boron nitride nano tube, and a titania nano tube.

55. :

A sensor unit as defined in claim 53,

wherein detects are introduced in said nano tube structure.

56. :

A sensor unit as defined in claim 53,

wherein an electric characteristic of said nano tube structure has a property like metals.

57. :

A sensor unit as defined in claim 48, further comprising;

a reaction field cell unit including a flow channel causing a sample to flow therethrough,

wherein said sensing part is provided in said flow channel.

69. :

An analytical apparatus, comprising;

a sensor unit as defined in claim 48.

58. :

A sensor unit for detecting a detection target, comprising;

a transistor part including a substrate, a source electrode and a drain electrode provided on said substrate, and a channel formed of a nano tube structure forming a current path between said source electrode and said drain electrode,

wherein a sensing site on which a specific substance capable of selectively interacting with the detection target is immobilized is formed on said channel, and

two or more of said transistor parts are integrated.

70. :

An analytical apparatus, comprising;

a sensor unit as defined in claim 58.

59. :

A sensor unit comprising;

a transistor part including a substrate, a source electrode and a drain electrode provided on aid substrate, a channel forming a current path between said source electrode and said drain electrode, and a sensing gate; and

a cell unit mounting part for mounting a reaction field cell unit including a sensing part on which a specific substance capable of selectively interacting with a detection target is immobilized,

wherein, when said reaction field cell unit is mounted in said cell unit mounting part, said sensing part and said sensing gate are brought into conduction.

71. :

An analytical apparatus, comprising;

a sensor unit as defined in claim 59.

60. :

A sensor unit comprising;

a transistor part including a substrate, a source electrode and a drain electrode provided on said substrate, a channel forming a current path between aid source electrode and said drain electrode, and a sensing gate; and

a cell unit mounting part for mounting a reaction field cell unit including a sensing part and a reference electrode to which a voltage is applied so as to detect existence of a detection target by a change of characteristic of said transistor part,

wherein, when said reaction field cell unit is mounted in said cell unit mounting part, said sensing part and said sensing gate are brought into conduction.

72. :

An analytical apparatus, comprising;

a sensor unit as defined in claim 60.

61. :

A reaction field cell unit mounted in a cell unit mounting part of a sensor unit comprising;

a transistor part including a substrate, a source electrode and a drain electrode provided on said substrate, a channel forming a current path between said source electrode and said drain electrode, and a sensing gate, and said cell unit mounting part, the reaction field cell unit comprising;

a sensing part on which a specific substance capable of selectively interacting with a detection target is immobilized,

wherein, when mounted in said cell unit mounting part, said sensing part and said sensing gate are in a conduction state.

62. :

A reaction field cell unit mounted in a cell unit mounting part of a sensor unit comprising;

a transistor part including a substrate, a source electrode and a drain electrode provided on said substrate, a channel forming a current path between said source electrode and said drain electrode, and a sensing gate, and said cell unit mounting part, the reaction field cell unit comprising;

a sensing part and a reference electrode to which a voltage is applied so as to detect existence of a detection target by a change of characteristic of said transistor part,

wherein, when mounted in said cell unit mounting part, said sensing part and said sensing gate are in a conduction state.

73. :

An analytical apparatus, comprising;

a sensor unit, comprising;

a substrate;

a first transistor part including a first source electrode and a first drain electrode provided on said substrate, and a first channel formed of a carbon nano tube forming a current path between said first source electrode and said first drain electrode; and

a second transistor part including a second source electrode and a second drain electrode provided on said substrate, and a second channel forming a current path between said second source electrode and said second drain electrode;

wherein at least one detection target selected from at least one measurement group selected from groups consisting of a nucleic acid-nucleic acid hybridization reaction measurement group, a nucleic acid-protein interaction measurement group, a receptor-ligand interaction measurement group, and an immunological reaction measurement group is detected as the change of the characteristic of the first transistor part and

at least one detection target selected from at least one measurement group selected from groups consisting of an electrolytic concentration measurement group, a biochemical item measurement group, a blood gases concentration measurement group, a blood cell count measurement group, and a blood coagulation ability measurement group is detected as the change of the characteristic of the second transistor part.

74. :

An analytical apparatus as defined in claim 73,

wherein a sensing site on which a specific substance capable of selectively interacting with the detection target is immobilized is formed in said first channel.