Pharmaceutical Compositions for Inhalation Containing an Anticholinergic, Corticosteroid, and Betamimetic

• US 20080063608A1
• Filed: 06/07/2007
• Published: 03/13/2008
• Est. Priority Date: 08/17/2002
• Status: Abandoned Application

• Current Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Original Assignee: Boehringer Ingelheim Pharma GmbH & Company Kg (C.H. Boehringer Sohn AG & Co. KG)
• Inventors: Meade, Christopher, Pairet, Michel, Pieper, Michael
• Application Number:
  US11/759,763
• Publication Number:
  US 20080063608A1
• Time in Patent Office: Days
• US Class Current: 424/46
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 9/0075 for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
• CPC Class Codes: A61K 9/008 comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]

Abstract

A pharmaceutical composition comprising:
(a) an anticholinergic of formula 1

• • wherein X⁻ is an anion with a single negative charge; (b) a corticosteroid; and (c) a betamimetic, wherein each component (a), (b), and (c) are optionally in the form of the solvates or hydrates thereof, processes for preparing them, and their use in the treatment of respiratory diseases.

Claims

1-21. -21. (canceled)

22. A pharmaceutical composition comprising:

(a) an anticholinergic of formula 1

wherein X⁻

is an anion with a single negative charge;

(b) a corticosteroid; and

(c) a betamimetic,

wherein each component (a), (b), and (c) is optionally in the form of a solvate or hydrate thereof, and

wherein the pharmaceutical composition is suitable for inhalation and a propellant-containing aerosol composition containing the anticholinergic, the corticosteroid, and the betamimetic in dissolved or dispersed form.

23. The propellant-containing aerosol composition according to claim 22, wherein the propellant gas is a hydrocarbon or halohydrocarbon or a mixture thereof.

24. The propellant-containing aerosol composition according to claim 23, wherein the propellant gas is selected from n-propane, n-butane, isobutane, or the chlorinated and/or fluorinated derivatives of methane, ethane, propane, butane, cyclopropane, or cyclobutane, or a mixture thereof.

25. The propellant-containing aerosol composition according to claim 22, wherein the propellant gas is TG134a, TG227, or a mixture thereof

26. The propellant-containing aerosol composition according to one of claims 22 to 25, further comprising a cosolvent, stabilizer, surfactant, antioxidant, lubricant, or means for adjusting the pH, or mixture thereof.

27. The propellant-containing aerosol composition according to one of claims 22 to 25, wherein the total amount of the anticholinergic, the corticosteroid, and the betamimetic is up to 5 wt.-% of the composition.